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Next Generation NOG mouse
List : Next Generation NOG mouse
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NOG-EXL
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- This strain is expressed with hGM-CSF and hIL3, which is human cytokines, inducing differentiation into myeloid cells.
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NOG-ΔMHC
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- MHC (Class I, Class II) deficient NOG mouse, which is severely immunodeficient mouse.
- Since mouse MHC is deficient, GVHD against xenotransplantation is greatly attenuated.
- GVHD after hPBMC engrafted is alleviated and long-term studies are able to be performed.
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FcResolv NOG
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- This strain is a FcgR knockout mouse derived from NOG mouse.
- Because the innate immunity includes macrophages of mouse is attenuated, the antitumor effects of immune checkpoint-inhibiting antibodies in humanized mouse engrafted with hematopoietic stem cells can be clearly evaluated compared to conventional humanized NOG mouse.
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FcResolv NOG-IL15
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- Humanized models transferred with human peripheral blood-derived NK cells are widely used.
- It is a model that enables long-term engraftment of human NK cells, and allows evaluation of ADCC activity by human NK cells, excluding mouse cell-mediated ADCC.
- FcResolv NOG-IL15 mice are useful for evaluating in vivo ADCC activity of antibody drug candidates.
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NOG-IL15
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- This strain is hIL-15 expressing NOG mouse.
- When human hematopoietic stem cells are engrafted, differentiation into NK cells becomes dominant compared to conventional NOG mouse.
- Differentiated NK cells express various NK receptors and produce granzyme A and perforin.
- Human NK cells can be engrafted and proliferated by engrafting PBMC-derived CD56+ NK cells. Suitable for studying Antibody-dependent Cellular Cytotoxicity (ADCC) activity.
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NOG-IL2
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- This is a severely immunodeficient NOG mouse that expresses hIL-2.
- Differentiation of engrafted hematopoietic stem cells into NK cells is promoted, and the number of CD56-positive NK cells is more than 10 times higher than that of conventional NOG mouse.
- Differentiated NK cells express various NK receptors and also produce Granzyme A and Perforin.
- Suitable for studying Antibody-Dependent Cellular Cytotoxicity (ADCC) activity.
- It is suitable as a model for engraftment and differentiation of IL2-dependent cells such as hematological tumors.
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NOG-IL6
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- This is a severely immunodeficient NOG mouse that expresses hIL-6.
- Differentiation of engrafted hematopoietic stem cells into monocytes is promoted.
- It is a suitable model for studies of tumor associate macrophages (TAM) or for the tumor transplantation model of IL-6 dependent acute myeloid leukemia.
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TK-NOG
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- TK-NOG mouse designed to express HSV-TK (Herpes Simplex Virus-1 Thymidine Kinase) in the liver under the control of the albumin gene enhancer/promoter and to induce liver-specific damage by ganciclovir administration.
- Human livers can be reconstituted by transplantation of normal human liver cells via the splenic portal vein into mice with liver injury.
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