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NOG mouse

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NOG mouse

Severely Immunodeficient NOG mouse

Severely Immunodeficient NOG mouse
Strain name NOG/Shi-scid, IL-2RγKO jic, (NOG mouse)
  • You will be required to sign a consent form upon purchase.
  • The use of this mouse strain corresponds to the use of Living Modified Organism (Cartagene Protocol, domestic law). We will send you an information provision form in advance, so please check it and use it according to the rules of each institution.
Development

A severely immunodeficient mouse developed by Dr. Mamoru Ito of the Central Institute for Experimental Animals.
Combining NOD-scid mouse with IL-2 receptor γ-chain knockout (IL2RγKO) mouse (Ohbo K et al., Blood 1996), a common domain of several cytokine receptors, presents an extremely severe combined immunodeficiency NOG (NOD/Shi-scid, IL-2Rγnull) mouse was developed (Blood 2002).

Product Features

The engraftment ratio of human cells/tissues is significantly higher than that of other immunodeficient mouse models, and it is possible to engraft human cancers and normal human tissues at a high ratio. In addition, after transfer of human hematopoietic stem cells, differentiation of human T cells is observed, which is not observed in SCID or nude mice. Therefore, it is considered that NOG is a useful model as a human immune system reconstituted mouse, and demand has been rapidly increased.

■ Expresses the following phenotypes

  • Lacking T and B cells
  • Lacking natural killer (NK) cells
  • Reduced dendritic cell function
  • Reduced macrophage function
  • Lacking complement activity
  • No T and B cell leakiness associated with aging
Research Applications
  • Humanized mouse model: human hematopoietic Stem Cells engraft/immune cells engraft model
  • Human tumor bearing model: Human PDX tumor bearing model, human hematologic cancer bearing model, etc.
  • Human infection models: EB virus, HTLV1 virus, HIV virus, etc.
  • GVHD model
  • Tumorigenicity test of regenerative medicine products, etc.
Background Data
Video : NOG mouse

We will introduce NOG mouse, their characteristics, and their main research applications.

References of NOG mouse

Humanized NOG mouse

Humanized NOG mouse

Human hematopoietic stem cell (HSC) and peripheral blood mononuclear cell (PBMC) engrafted models are commonly used.
We produce humanized NOG mouse in Japan and deliver them to customers.
Production will be started after receiving your firm order. We usually ship about 12 weeks after an order is placed.
You will be required to sign a consent form upon purchase.
The use of this mouse strain corresponds to the use of Living Modified Organism (Cartagene Protocol, domestic law). We will send you an information provision form in advance, so please check it and use it according to the rules of each institution.

The features of humanized NOG mouse engrafted with hHSC (human Hematopoietic Stem Cells)
  • When HSCs are engrafted, HSCs mainly differentiate into human T cells and human B cells.
  • Some of NK cells, Macrophages, and Monocytes are existed, but they are very few. (Human immune cells at the time of shipment are mainly composed of T cells and B cells. Macrophages derived from mouse are exist.)
  • Humanized mouse has been confirmed to survive for more than 6 months after HSCs engrafted.
  • It has been confirmed that the engraftment ratio of human immune cells remains almost unchanged up to 20 weeks after HSC engraftment.
  • Graft versus host disease (GVHD) caused by human immune cells is not usually observed.
  • Even if cancer cells are transplanted after engraftment of human immune cells, it has been confirmed that transplant of cancer cells occurs in many cases.
  • Differentiated human T cells have been confirmed to be activated by drugs and cytokines and have cytotoxic activity against cancer cells.
  • Differentiated human B cells produce antigen-specific IgM. (When immunized with DNP-KLH and Ovalbumin, there is a track record of producing antigen specific IgM.)
  • NOG mouse with humanized immune systems is supplied by TACONIC Biosciences Inc. in the US and EU countries.
  • They are as same quality standard as humanized mouse supplied in Japan.
Research applications
  • Cancer immunotherapy model: A model that has human immune cells and human cancer at the same time, and is a model for evaluating immune checkpoint inhibitors or cancer vaccines.
  • Human-specific viral infection model: A model that has human immune cells and infected with EB virus, human immunodeficiency virus (HIV), human adult T-cell leukemia virus (HTLV1), etc.
  • Allergy model: Allergy model mediated by the human immune cells by administering antigens, antibodies, and cytokines.
  • We provide detailed information exchange meeting by online, regarding the features of humanized mice, and experimental protocols for use.
  • Please feel free to contact us at sales@invivoscience.com.
Background data : HSC engrafted NOG mouse
Video : HSC engrafted NOG mouse

We will introduce the method of producing HSC engrafted humanized NOG mouse, their characteristics, and their main research applications.

The features of humanized NOG mouse engrafted with hPBMC (human Peripheral Blood Mononuclear Cells)
  • hCD3-positive T cells are well engrafted. hCD4 positive T cells, and hCD8 positive T cells are also identified.
  • Two to three weeks after engraftment, T cells were detected in the peripheral blood, and many T cells also infiltrated the spleen, lungs, and liver.
  • Although the engrafted ratio varies depending on the PBMC lots, approximately 20% or more of human cells are colonized.
  • When 1 × 107 PBMCs are engrafted, GVHD develops in about 3 weeks after engraftment, and death will be occurred in about 1-2 months. NOG-ΔMHC mouse that can suppress the development of GVHD can provide for long-term experiments.
Research applications of PBMC engrafted humanized NOG mouse
  • GVHD model
  • Rejection model
  • Short-term HIV viral infection model
  • We provide detailed information exchange meeting by online regarding the features of humanized mice, the production of humanized mice, and experimental protocols for use. Please feel free to contact us at sales@invivoscience.com
Background data : PBMC engrafted NOG mouse
Video : PBMC engrafted NOG mouse

We will introduce the method of producing PBMC engrafted humanized NOG mouse, their characteristics, and their major research applications.

References of NOG mouse

References

2023

HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.(Bladder cancer; Glycolysis; IGF2BP1; Immunesensitivity ; PKM2; circFAM13B. Humanized NOG
J Exp Clin Cancer Res. 2023 Feb 6;42(1):41. doi: 10.1186/s13046 023 02614 3.
Lv J, Li K, Yu H, Han J, Zhuang J, Yu R, Cheng Y, Song Q, Bai K, Cao Q, Yang H, Yang X, Lu Q.

Spontaneous early-onset neurodegeneration in the brainstem and spinal cord of NSG, NOG, and NXG mice.(CD34; NOG; NSG; NXG; gliosis; neurodegeneration; spontaneous lesion; vacuolation.)
Vet Pathol . 2023 May;60(3):374-383. doi: 10.1177/03009858231151403. Epub 2023 Feb 2.
Finesso G, Willis E, Tarrant JC, Lanza M, Sprengers J, Verrelle J, Banerjee E, Hermans E, Assenmacher CA, Radaelli E.

A repeat-dose toxicity study of human umbilical cord mesenchymal stem cells in NOG mice by intravenous injection.(Human umbilical cord mesenchymal stem cells; NOG mice; colonization; distribution; repeat dose toxicity.)
Expert Opin Drug Metab Toxicol. 2023 Jul Dec;19(11):857 866. doi: 10.1080/17425255.2023.2279243. Epub 2023 Nov 17.
Shao J, Xia L, Ye Z, Yang Q, Zhang C, Shi Y, Zhang L, Gu L, Xu C, Chen Y, Chen Y, Pan X, Wu F, Pan R, Liang J, Zhang L.

Clinicopathological characteristics associated with the engraftment of patient lymphoma cells in NOG mice.(Diffuse large B-cell lymphoma; NOG mouse; Patient derived lymphoma cells.)
Int J Hematol . 2023 Aug;118(2):221 230. doi: 10.1007/s12185 023 03604 z. Epub 2023 May 2.
Sahashi S, Shimada K, Takagi Y, Aoki T, Kunou S, Sakamoto A, Murase A, Furukawa K, Kagaya Y, Yamaga Y, Takai M, Tokuyama K, Shimada S, Nakamura S, Kiyoi H.

Effect of Systemic Administration of CD4-T cells and Local Administration of T cell Stimulants on T cell Activity in Psoriatic Skin Xenografts on NOG Mice.(CD4+ T Lymphocytes, Heterograft, Psoriasis, NOG mouse)
Comp Med. 2023 Aug 27;73(4):285-293. doi: 10.30802/AALAS CM 23 000006.
Christensen PK, Hansen AK, Skov S, Larsen J, Høyer-Hansen MH, Koch J.

Baicalein Inhibits the Growth of Transplanted Esophageal Cancer in Mice and the Effect on the Expression of PAK4.(PAK4; baicalein; esophageal cancer; NOG mice; transplanted tumor of esophageal cancer)
Bull Exp Biol Med. 2023 Feb;174(4):478-481. doi: 10.1007/s10517 023 05733 1. Epub 2023 Mar 10.
Liu Y, Sun X, Liu J, Liu W, Jin J, Liu Y.

Establishment of a human microbiome and immune system reconstituted dual humanized mouse model.(CD34+ cells; NOG mice; fecal microbiota transplantation; germ free; humanized mice)
Exp Anim. 2023 Aug 7;72(3):402-412. doi: 10.1538/expanim.23 0025. Epub 2023 Apr 4.
Ka Y, Ito R, Nozu R, Tomiyama K, Ueno M, Ogura T, Takahashi

Lysine N-methyltransferase SETD7 promotes bladder cancer progression and immune escape via STAT3/PD L1 cascade.(SETD7; bladder cancer; immune escape; migration; proliferation; Humanized NOG mice)
Int J Biol Sci.2023 Jul 16;19(12):3744 3761. doi: 10.7150/ijbs.87182. eCollection 2023.
Lv J, Wu Q, Li K, Bai K, Yu H, Zhuang J, Sun H, Yang H, Yang X, Lu Q.

Murine models to study human NK cells in human solid tumors.(human in mouse model; humanized NOG mice; natural killer cells; solid tumor; tumor immunity)
Front Immunol. 2023 Jun 14:14:1209237. doi: 10.3389/fimmu.2023.1209237. eCollection 2023.
Parodi M, Astigiano S, Carrega P, Pietra G, Vitale C, Damele L, Grottoli M, Guevara Lopez ML, Ferracini R, Bertolini G, Roato I, Vitale M, Orecchia P.

Clinically relevant humanized mouse models of metastatic prostate cancer to evaluate cancer therapies.(humanized mice, NOG, NOG-EXL, Hot Model, Cold Model, metastatic prostate cancer, cancer therapy)
bioRxiv. 2023 Oct 17:2023.10.13.562280. doi: 10.1101/2023.10.13.562280.
Kostlan RJ, Phoenix JT, Budreika A, Ferrari MG, Khurana N, Cho JE, Juckette K, McCollum BL, Moskal R, Mannan R, Qiao Y, Griend DJV, Chinnaiyan AM, Kregel S.

Characterization of anti-CD79b/CD3 bispecific antibody, a potential therapy for B cell malignancies.(Bispecific; CD79b; Immunotherapy; Non Hodgkin lymphoma; T cell engager; PBMC engrafted NOG mice)
Cancer Immunol Immunother . 2023 Feb;72(2):493 507. doi: 10.1007/s00262 022 03267 5. Epub 2022 Aug 13.
Wang J, Li C, He K, Kuang Z, Lu J, Yao Y, He F, Li N, Li L, Fu F, Wu Z, Zhou S, Kang D, Qiu X, Wu M, Liu Y, Cao X, Xu M, Chen B, Wu W, Guo F.

Methods for preparing tissue microarray slides using xenografts with different levels of HER2 expression to standardize HER2 detection.(HER2 test; gastric cancer; immunohistochemistry; tissue microarray; xenograft; NOG
Pathol Int. 2023 Jan;73(1):39-44. doi: 10.1111/pin.13288. Epub 2022 Nov 18.
Yorozu K, Kurasawa M, Iino Y, Nakamura Y, Hashizume K, Harada N, Ochiai A.

Efficacy of adoptively transferred allogeneic CIK cells on colorectal cancer: Augmentative antitumoral effects of GvHD.(Adoptive transfer; Colorectal neoplasms; Cytokine induced killer cells; Graft vs host disease; Treatment outcome; Xenograft model antitumor assays.)
Int Immunopharmacol 2023 Jan:114:109446. doi: 10.1016/j.intimp.2022.109446. Epub 2022 Dec 1.
Muhammadnejad S, Monzavi SM, Torabi Rahvar M, Sotoudeh M, Muhammadnejad A, Tavakoli Shiraji S, Ranjbar A, Aghayan SS, Khorsand AA, Moradzadeh K, Janzamin E, Ahmadbeigi N.

Lansoprazole inhibits the development of sessile serrated lesions by inducing G1 arrest via Skp2/p27 signaling pathway.(Chemoprevention; Connectivity map; Lansoprazole; Organoid; Sessile serrated lesion; NOG mice)
J Gastroenterol. 2023 Nov 22. doi: 10.1007/s00535-023-02052-0. Online ahead of print.
Kawaguchi T, Okamoto K, Fujimoto S, Bando M, Wada H, Miyamoto H, Sato Y, Muguruma N, Horimoto K, Takayama T. Human serum

Human serum albumin promotes self-renewal and expansion of umbilical cord blood CD34+ hematopoietic stem/progenitor cells.(Hematopoietic stem/progenitor cells (HSPCs); expansion in vitro; human serum albumin (HSA); transplantation; NOG)
Ann Transl Med . 2023 Jan 31;11(2):62. doi:10.21037/atm 22 6383. Epub 2023 Jan 13.
Hua J, Jiao T, Qiao Y, Zhang S, Xiao T, Zhang Y, Yan J.

A Novel Approach for Determining the Critical Quality Attributes of Mesenchymal Stem Cells by Specifying Cell Population With Replication Potential.(Redox system; critical process parameter; critical quality attribute; mesenchymal stem cells; mitochondrial function; NOG mice)
Stem Cells Transl Med. 2023 Mar 17;12(3):169 182. doi: 10.1093/ stcltm /szad005
Yamamoto T, Arita M, Tamura T, Saito M, Katayama H, Kuroda H, Suzuki T, Kawamata S.

Annihilation of Non-small Cell Lung Cancer by NKG2D CAR T Cells Produced from T Cells from Peripheral Blood of Healthy Donors. (CAR T cells; NKG2D NKG2DL signaling; antitumor effect; non small cell lung cancer; solid tumor; NOG mice))
J Interferon Cytokine Res. 2023 Oct;43(10):445 454. doi: 10.1089/jir.2023.0043.
Jiang J, Liu Y, Zeng Y, Fang B, Chen Y.

Pharmacology, pharmacokinetics, and toxicity characterization of a novel anti-CD73 therapeutic antibody IBI325 for cancer immunotherapy (CD73 antagonist; Cancer immunotherapy; IBI325; Therapeutic antibody; hPBMC reconstituted NOG mouse)
Int J Biol Macromol . 2023 Feb 28:229:158 167. doi: 10.1016/j.ijbiomac.2022.12.258. Epub 2022 Dec 29.
Zhou Y, Shen H, Wu M, Wang J, Wu Z, Fu F, Liu Y, Lu J, Yao Y, Luo N, Zhou S, Tan KS, Chen B, Wang D.

PEGylated Polymeric Nanoparticles Loaded with 2-Methoxyestradiol for the Treatment of Uterine Leiomyoma in a Patient Derived Xenograft Mouse Model.(Bioavailability; Drug delivery system; Estrogen; Fibroid; Nanoparticles; Precision medicine; NOG mice)
J Pharm Sci. 2023 Sep;112(9):2552-2560. doi: 10.1016/j.xphs.2023.07.018. Epub 2023 Jul 21.
Enazy SA, Kirschen GW, Vincent K, Yang J, Saada J, Shah M, Oberhauser AF, Bujalowski PJ, Motamedi M, Salama SA, Kilic G, Rytting E, Borahay MA.

Next generation oncolytic viruses expressing PADI1 and TIMP2 exhibit anti-tumor activity against melanoma in nude and humanized mouse models.(PADI1; TIMP2; animal studies; arginine deiminase; arginine deprivation; cancer models; humanized NOG tumor model; immunotherapy; melanoma; oncolytic adenovirus.)
Mol Ther Oncolytics. 2023 Jan 13:28:158 170. doi: 10.1016/j.omto.2023.01.002. eCollection 2023 Mar 16.
Kuryk L, Møller AW.

DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming.(AML; DNMT3A mutation; Metabolic reprogramming; NAM-NAD metabolism; NAMPT; NOG mice)
J Transl Med. 2023 Jul 18;21(1):481. doi: 10.1186/s12967 023 04323 z.
Yang X, Wang X, Yang Y, Li Z, Chen Y, Shang S, Wang Y.

Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukemia protein 1 H3K4me3 mediated immune escape in esophageal squamous cell carcinoma.(esophageal squamous cell carcinoma; immune escape; immunotherapy; lncRNA; mixed lineage leukemia protein-1 (MLL1); huPBMC NOG mice)
Clin Transl Med. 2023 Sep;13(9):e1410. doi: 10.1002/ctm2.1410.
Liu J, Zhou WY, Luo XJ, Chen YX, Wong CW, Liu ZX, Bo Zheng J, Yu Mo H, Chen JQ, Li JJ, Zhong M, Xu YH, Zhang QH, Pu HY, Wu QN, Jin Y, Wang ZX, Xu RH, Luo HY.

Disintegration of the NuRD Complex in Primary Human Muscle Stem Cells in Critical Illness Myopathy (critical illness; epigenetic; histone 1; muscle stem cell; NOG mice)
Int J Mol Sci. 2023 Feb 1;24(3):2772. doi: 10.3390/ijms24032772.
Schneider J, Sundaravinayagam D, Blume A, Marg A, Grunwald S, Metzler E, Escobar H, Müthel S, Wang H, Wollersheim T, Weber-Carstens S, Akalin A, Di Virgilio M, Tursun B, Spuler S.

2022

NOD/SCID/gamma(c)(null) mouse:an excellent recipient mouse model for engraftment of human cells. (NOG, original paper)
Blood. 2002 Nov 1;100(9):3175 82. doi: 10.1182/blood 2001 12 0207.
Mamoru Ito, Hidefumi Hiramatsu, Kimio Kobayashi, Kazutomo Suzue, Mariko Kawahata, Kyoji Hioki, Yoshito Ueyama, Yoshio Koyanagi, Kazuo Sugamura, Kohichiro Tsuji, Toshio Heike, Tatsutoshi Nakahata

High Incidence of Lymph-node Metastasis in a Pancreatic-cancer Patient-derived Orthotopic Xenograft (PDOX) NOG-Mouse Model. (NOG, PODX-Pancreatic cancer)
Anticancer Res. 2022 Feb;42(2):739-743. doi:10.21873/anticanres.15532.
Norihiko Sugisawa , Kentaro Miyake, Takashi Higuchi, Hiromichi Oshiro, Jun Ho Park, Kei Kawaguchi, Michael Bouvet, Michiaki Unno, Robert M Hoffman

Discovery of potent immune modulating molecule taccaoside A against cancers from structures active relationships of natural steroidal saponins.(NOG, immune modulating molecule)
Phytomedicine. 2022 Sep;104:154335. doi: 10.1016/j.phymed.2022.154335. Epub 2022 Jul 11.
Zhi Dai, Pei-Feng Zhu, Hui Liu, Xuan-Chen Li, Yan-Yan Zhu, Yang-Yang Liu, Xiao-Long Shi, Wei-Di Chen, Ya-Ping Liu, Yun-Li Zhao, Li-Xing Zhao, Hai-Yang Liu, Xiao-Dong Luo

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity. (NOG, CAR-T)
Blood. 2022 Jan 27;139(4):523-537. doi: 10.1182/blood.2021011597.
Christopher Ronald Funk, Shuhua Wang, Kevin Z Chen, Alexandra Waller, Aditi Sharma, Claudia L Edgar, Vikas A Gupta, Shanmuganathan Chandrakasan, Jaquelyn T Zoine, Andrew Fedanov, Sunil S Raikar, Jean L Koff, Christopher R Flowers, Silvia Coma, Jonathan A Pachter, Sruthi Ravindranathan, H Trent Spencer, Mala Shanmugam, Edmund K Waller

Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma (NOG, IL22 cutaneous T-cell lymphoma).
Cancer Sci. 2022 Apr;113(4):1208-1219. doi: 10.1111/cas.15296. Epub 2022 Feb 20.
Matsuda Y, Ikeda S, Abe F, Takahashi Y, Kitadate A, Takahashi N, Wakui H, Tagawa H.

Establishment of Patient-derived Preclinical Models for Invasive Papillary Cholangiocarcinoma. (NOG, Invasive Papillary Cholangiocarcinoma PDX)
Anticancer Res. 2022 Jan;42(1):599-608. doi: 10.21873/anticanres.15517.
Mwesige B, Lee MR, Lee YS, Han NY, Im JE, Kim JK, Choi SI, Hong EK, Jeon AR, Park SJ, Woo SM, Kim YH.

Inhibition of MACC1-Induced Metastasis in Esophageal and Gastric Adenocarcinomas. (NOG, Metastasis, Esophageal, Gastric Adenorcinoma).
Cancers (Basel). 2022 Mar 31;14(7):1773. doi: 10.3390/cancers14071773.
Treese C, Werchan J, von Winterfeld M, Berg E, Hummel M, Timm L, Rau B, Daberkow O, Walther W, Daum S, Kobelt D, Stein U.

Glucose metabolism inhibitor PFK-015 combined with immune checkpoint inhibitor is an effective treatment regimen in cancer. (PBMC humanized mice, NOG, Cancer Immunotherapy)
Oncoimmunology. 2022 May 25;11(1):2079182. doi: 10.1080/2162402X.2022.2079182. eCollection 2022.
Zheng JB, Wong CW, Liu J, Luo XJ, Zhou WY, Chen YX, Luo HY, Zeng ZL, Ren C, Xie XM, Wang DS.

Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML. (AML-PDX, NOG, NOG-EXL)
In Vivo. 2022 Jul-Aug;36(4):1615-1627. doi: 10.21873/invivo.12872.
Daniel H Albert, Neal C Goodwin, Angela M Davies, Jenny Rowe, Gerold Feuer, Michael Boyiadzis, Kathleen A Dorritie, Maria Mancini, Regina Gandour-Edwards, Brian A Jonas, Gautam Borthakur, Ibrahim Aldoss, David A Rizzieri, Olatoyosi Odenike, Thomas Prebet, Sanjana Singh, Relja Popovic, Y U Shen, Keith F McDaniel, Warren M Kati, Dimple A Modi, Monica Motwani, Johannes E Wolff, David J Frost

Spontaneous xenogeneic GvHD in Wilms' tumor Patient-Derived xenograft models and potential solutions. (NOG, Wilmsʼ tumor, PDX)
Animal Model Exp Med. 2022 Dec;5(4):389-396. doi: 10.1002/ame2.12254. Epub 2022 Jun 20.
Seyed Mostafa Monzavi , Ahad Muhammadnejad, Maryam Behfar, Amir Arsalan Khorsand, Samad Muhammadnejad, Abdol-Mohammad Kajbafzadeh

The first Japanese biobank of patient-derived pediatric acute lymphoblastic leukemia xenograft models. (NOG, ALL-PDX)
Cancer Sci. 2022 Jul 25. doi: 10.1111/cas.15506.
Kuniaki Tanaka, Itaru Kato, Yuu Dobashi, Jun-Ichi Imai, Takashi Mikami, Hirohito Kubota, Hiroo Ueno, Mamoru Ito, Seishi Ogawa, Tatsutoshi Nakahata, Junko Takita, Hidemi Toyoda, Chitose Ogawa, Souichi Adachi, Shinya Watanabe, Hiroaki Goto

Flow Cytometric Measurement of Reactive Oxygen Species to Assess the Effects of Preconditioning Total Body Irradiation on NOG Mice. (Preconditioning; Irradiation、NOG)
Asian Pac J Cancer Prev. 2022 Feb 1;23(2):383-388. doi: 10.31557/APJCP.2022.23.2.383.
Kavianpour M, Moradzadeh K, Muhammadnejad S, Jabbarpour Z, Khorsand AA, Aghayan S, Vasei M, Verdi J.

Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice. (humanized mice, NOG, diabetes, human mesenchymal stromal/stem cells)
Stem Cell Res Ther. 2022 Jul 26;13(1):350. doi: 10.1186/s13287-022-03048-y.
Ghoneim MA, Gabr MM, Refaie AF, El-Halawani SM, Al-Issawi MM, Elbassiouny BL, Kader MAAE, Ismail AM, Zidan MF, Karras MS, Magar RW, Khater SM, Ashamallah SA, Zakaria MM, Kloc M.

Characterization of anti-CD79b/CD3 bispecific antibody, a potential therapy for B cell malignancies. (humanized mice, NOG, PBMC, B cell malignancies)
Cancer Immunol Immunother. 2022 Aug 13. doi: 10.1007/s00262-022-03267-5.
Wang J, Li C, He K, Kuang Z, Lu J, Yao Y, He F, Li N, Li L, Fu F, Wu Z, Zhou S, Kang D, Qiu X, Wu M, Liu Y, Cao X, Xu M, Chen B, Wu W, Guo F.

CD169 (Siglec-1) as a Robust Human Cell Biomarker of Toll-Like Receptor 9 Agonist Immunotherapy (humanized mice, NOG, Immunotherapy, HIV-1)
Front Cell Infect Microbiol. 2022 Jul 5;12:919097. doi: 10.3389/fcimb.2022.919097. eCollection 2022.
Lende SSF, Pahus MH, Monrad I, Olesen R, Mahr AR, Vibholm LK, Østergaard L, Søgaard OS, Andersen AHF, Denton PW, Tolstrup M.

2021

Imaging Tumor-Infiltrating Lymphocytes in Brain Tumors with [64Cu]Cu-NOTA-anti-CD8 PET. (Brain tumor, PBMC, humanized mice, NOG)
Clin Cancer Res. 2021 Apr 1;27(7):1958-1966. doi: 10.1158/1078-0432.CCR-20-3243. Epub 2021 Jan 25.
Veronica L Nagle, Kelly E Henry, Charli Ann J Hertz, Maya S Graham, Carl Campos, Luis F Parada, Neeta Pandit-Taskar, Andrea Schietinger, Ingo K Mellinghoff, Jason S Lewis

Adaptive NK Cell Therapy Modulated by Anti-PD-1 Antibody in Gastric Cancer Model. (Cancer Immune therapy, Gastric cancer, NOG)
Front Pharmacol. 2021 Sep 13;12:733075. doi: 10.3389/fphar.2021.733075. eCollection 2021.
Shahrokh Abdolahi, Zeinab Ghazvinian, Samad Muhammadnejad, Mohammad Ahmadvand, Hamid Asadzadeh Aghdaei, Somayeh Ebrahimi-Barough, Jafar Ai, Mohammad Reza Zali, Javad Verdi, Kaveh Baghaei

Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.(chemotherapy, neuroblastoma, NOG)
Int J Cancer. 2021 Mar 1;148(5):1219-1232. doi: 10.1002/ijc.33423. Epub 2020 Dec 17.
Birte Arlt, Christin Zasada, Katharina Baum, Jasmin Wuenschel, Guido Mastrobuoni, Marco Lodrini, Kathy Astrahantseff, Annika Winkler, Johannes H Schulte, Sabine Finkler, Martin Forbes, Patrick Hundsdoerfer, Dennis Guergen, Jens Hoffmann, Jana Wolf, Angelika Eggert, Stefan Kempa, Hedwig E Deubzer

Characterization of a xenograft model for anti-CD19 CAR T cell studies. (CAR-T, Lymphoma, NOG)
Clin Transl Oncol. 2021 Oct;23(10):2181-2190. doi: 10.1007/s12094-021-02626-5. Epub 2021 May 3.
N Ahmadbeigi, S Alatab, M Vasei, A Ranjbar , S Aghayan, A Khorsand, K Moradzadeh , Z Darvishyan, M Jamali, S Muhammadnejad

Ex Vivo Expanded and Activated Natural Killer Cells Prolong the Overall Survival of Mice with Glioblastoma-like Cell-Derived Tumors. (hNK, Glioblastoma, NOG).
Int J Mol Sci. 2021 Sep 15;22(18):9975. doi: 10.3390/ijms22189975.
Shida Y, Nakazawa T, Matsuda R, Morimoto T, Nishimura F, Nakamura M, Maeoka R, Yamada S, Nakagawa I, Park YS, Yasukawa M, Tojo T, Tsujimura T, Nakase H.

HER2-antigen-specific humoral immune response in breast cancer lymphocytes transplanted in hu-PBL hIL-4 NOG mice.
Sci Rep. 2021 Jun 17;11(1):12798. doi: 10.1038/s41598-021-92311-y. (NOG-IL4, Cancer Immune therapy)
Yusuke Ohno, Shino Ohshima, Asuka Miyamoto, Fuyuki Kametani, Ryoji Ito, Banri Tsuda, Yukie Kasama, Shunsuke Nakada, Hirofumi Kashiwagi, Toshiro Seki, Atsushi Yasuda, Kiyoshi Ando, Mamoru Ito, Yutaka Tokuda, Yoshie Kametani

Targeting the Endothelin-1 Receptors Curtails Tumor Growth and Angiogenesis in Multiple Myeloma.(Multiple myeloma, NOG)
Front Oncol. 2021 Jan 8;10:600025. doi: 10.3389/fonc.2020.600025. eCollection 2020.
Russignan A, Dal Collo G, Bagnato A, Tamassia N, Bugatti M, Belleri M, Lorenzi L, Borsi E, Bazzoni R, Gottardi M, Terragna C, Vermi W, Giacomini A, Presta M, Cassatella MA, Krampera M, Tecchio C.

MNS1 promotes hepatocarcinogenesis and metastasis via activating PI3K/AKT by translocating β-catenin and predicts poor prognosis. (Hepatocarcinogenesis, metastasis, NOG).
Liver Int. 2021 Jun;41(6):1409-1420. doi: 10.1111/liv.14803. Epub 2021 Feb 16.
Yi Y, Yu MC, Fu PY, Liu G, Zhou PY, Guan RY, Zhou C, Sun BY, Qiu SJ.

Human endometrial perivascular stem cells exhibit a limited potential to regenerate endometrium after xenotransplantation.(endometrial perivascular stem cells, NOG)
Hum Reprod. 2021 Jan 1;36(1):145-159.
Xinxin Zhu, Fei Yu, Guijun Yan, Yali Hu, Haixiang Sun, Lijun Ding

Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease. (humanized mice, NOG, GVHD)
2021 Nov 11;7(11):e08380.
Hiroshi Tsuzuki, Yasuko Nagatsuka, Mitsuhiro Iwata, Noboru Kitamura, Yosuke Nagasawa, Taro Matsumoto, Ryoji Ito, Takeshi Takahashi, Mamoru Ito, Hideki Nakamura, Masami Takei

Utilization of a novel Sendai virus vector in ex vivo gene therapy for hemophilia A. (gene therapy, hemophilia A, NOG)
Int J Hematol. 2021 Apr;113(4):493-499. doi: 10.1007/s12185-020-03059-6. Epub 2021 Jan 1.
Yamaki Y, Fukushima T, Yoshida N, Nishimura K, Fukuda A, Hisatake K, Aso M, Sakasai T, Kijima-Tanaka J, Miwa Y, Nakanishi M, Sumazaki R, Takada H.

CD1d expression in glioblastoma is a promising target for NKT cell-based cancer immunotherapy. (Cancer immunotherapy, iNKT cells, NOG).
Cancer Immunol Immunother. 2021 May;70(5):1239-1254. doi: 10.1007/s00262-020-02742-1. Epub 2020 Oct 31.
Hara A, Koyama-Nasu R, Takami M, Toyoda T, Aoki T, Ihara F, Kobayashi M, Hirono S, Matsutani T, Nakayama T, Iwadate Y, Motohashi S.

Establishment of a Patient-Derived Xenograft Model of Colorectal Cancer in CIEA NOG Mice and Exploring Smartfish Liquid Diet as a Source of Omega-3 Fatty Acids. (NOG, Colorectal Cancer PDX)
Biomedicines. 2021 Mar 10;9(3):282. doi:10.3390/biomedicines9030282.
Helle Samdal, Lene C Olsen, Knut S Grøn, Elin S Røyset, Therese S Høiem, Ingunn Nervik, Pål Sætrom, Arne Wibe, Svanhild A Schønberg, Caroline H H Pettersen

Plasmodium falciparum-infected humanized mice: a viable preclinical tool. (NOG, Plasmodium falciparum)
Immunotherapy. 2021 Nov;13(16):1345-1353. doi: 10.2217/imt-2021-0102. Epub 2021 Aug 23.
Tyagi RK.

Efficient production of immunodeficient non-obese diabetic/Shi-scid IL2r γnull mice via the superovulation technique using inhibin antiserum and gonadotropin. (NOG production)
Lab Anim. 2021 Feb;55(1):13-20. doi: 10.1177/0023677220928091. Epub 2020 Jun 6.

Data on long-term survival of the NOD/Shi-scid IL-2Rγ null (NOG) mouse in two facilities. (survival data, NOG)
J Toxicol Sci. 2021;46(10):453-469. doi: 10.2131/jts.46.453.
Yamashita Y, Sato T, Noishiki K, Kobayashi K, Uchiyama A, Izumi H, Tamura T, Shikamura M, Oinishi Y, Saito M, Kawamata S.

Human Microglia Extensively Reconstitute in Humanized-BLT Mice With Human Interleukin-34 Transgene and Support HIV-1 Brain Infection. (HIV1, NOG, humanized-BLT mice)
Front Immunol. 2021 May 21;12:672415. doi: 10.3389/fimmu.2021.672415. eCollection 2021.
Zhang J, Lohani SC, Cheng Y, Wang T, Guo L, Kim WK, Gorantla S, Li Q.

Establishment of Human Leukocyte Antigen-Mismatched Immune Responses after Transplantation of Human Liver Bud in Humanized Mouse Models. (NOG, humanized mice, HLA mismatched model)
Cells. 2021 Feb 23;10(2):476.
Akihiro Mori, Soichiro Murata, Nao Tashiro, Tomomi Tadokoro, Satoshi Okamoto, Ryo Otsuka, Haruka Wada, Tomoki Murata, Takeshi Takahashi, Ken-Ichiro Seino, Hideki Taniguchi

Liposomal 2-Methoxyestradiol Nanoparticles for Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model. (NOG, Uterine Leiomyoma PDX)
Reprod Sci. 2021 Jan;28(1):271-277. doi: 10.1007/s43032-020-00248-w. Epub 2020 Jul 6.
Mostafa A Borahay, Kathleen L Vincent, Massoud Motamedi, Ibrahim Tekedereli, Salama A Salama, Bulent Ozpolat, Gokhan S Kilic

Elimination of residual undifferentiated induced pluripotent stem cells (iPSCs) using irradiation for safe clinical applications of iPSC-derived cardiomyocytes. (iPSC-derived cardiomyocytes, Tumorigenicity test in NOG)
Biochem Biophys Res Commun. 2021 Oct 15;574:91-96. doi: 10.1016/j.bbrc.2021.08.065. Epub 2021 Aug 24.
Takeda M, Ito E, Minami K, Harada A, Mochizuki-Oda N, Sawa Y, Miyagawa S.

Scaffold-Free Tubular Engineered Heart Tissue From Human Induced Pluripotent Stem Cells Using Bio-3D Printing Technology in vivo. (engineered heart tissue; human-induced pluripotent stem cell, NOG)
Front Cardiovasc Med. 2022 Jan 20;8:806215. doi: 10.3389/fcvm.2021.806215. eCollection 2021.
Kawai Y, Tohyama S, Arai K, Tamura T, Soma Y, Fukuda K, Shimizu H, Nakayama K, Kobayashi E.

Development of a novel anti-B7-H4 antibody enhances anti-tumor immune response of human T cells.(anti-B7-H4 antibody in vivo antitumor efficacy test, NOG)
Biomed Pharmacother. 2021 Sep;141:111913. doi: 10.1016/j.biopha.2021.111913. Epub 2021 Jul 13.
Miao G, Sun X.

2020

Establishment of Humanized Mice from Peripheral Blood Mononuclear Cells or Cord Blood CD34+ Hematopoietic Stem Cells for Immune-Oncology Studies Evaluating New Therapeutic Agents. (humanized mice, NOG, Cancer immune-therapy)
Curr Protoc Pharmacol. 2020 Jun;89(1):e77
Verma B, Wesa A.

89 Zr-pembrolizumab biodistribution is influenced by PD-1-mediated uptake in lymphoid organs. (Cancer Immune therapy, humanized mice, NOG)
Elly L van der Veen, Danique Giesen, Linda Pot-de Jong, Annelies Jorritsma-Smit, Elisabeth G E De Vries, Marjolijn N Lub-de Hooge
Elly L van der Veen, Danique Giesen, Linda Pot-de Jong, Annelies Jorritsma-Smit, Elisabeth G E De Vries, Marjolijn N Lub-de Hooge

Supporting clinical decision making in advanced melanoma by preclinical testing in personalized immune-humanized xenograft mouse models. (humanized mice, NOG, NOG-IL2, melanoma PDX, Cancer Immune therapy)
Ann Oncol. 2020 Feb;31(2):266-273. doi: 10.1016/j.annonc.2019.11.002. Epub 2020 Jan 3.
L Ny, L Y Rizzo, V Belgrano, J Karlsson, H Jespersen, L Carstam, R O Bagge, L M Nilsson, J A Nilsson

Co-expressing LRP6 With Anti-CD19 CAR-T Cells for Improved Therapeutic Effect Against B-ALL. (CD19 CAR-T, B-ALL, NOG)
Front Oncol. 2020 Sep 15;10:1346. doi: 10.3389/fonc.2020.01346. eCollection 2020.
Ping He, Zhongqiu Tan, Zhongheng Wei, Cheng-Liang Wan, Shan-Shan Yang

Development and characterization of a novel anti-OX40 antibody for potent immune activation.(anti-OX40 antibody, NOG, Cancer Immune therapy)
Cancer Immunol Immunother. 2020 Jun;69(6):939-950. doi: 10.1007/s00262-020-02501-2. Epub 2020 Feb 20.
Kuang Z, Jing H, Wu Z, Wang J, Li Y, Ni H, Zhang P, Wu W, Wu M, Zhou S, Qiu X, Wu D, Prinz B, Baruah H, Chen B, Yu M, Liu J.

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection (HIV, humanized mice, NOG)
. J Vis Exp. 2020 Jan 31;(155).
Anna H F Andersen, Stine S F Nielsen, Rikke Olesen, Katharina Mack, Frederik Dagnæs-Hansen, Niels Uldbjerg, Lars Østergaard, Ole S Søgaard, Paul W Denton, Martin Tolstrup

Verification of EZH2 as a druggable target in metastatic uveal melanoma. (metastasis melanoma, NOG)
Mol Cancer. 2020 Mar 4;19(1):52. doi:10.1186/s12943-020-01173-x.
Bei Jin, Ping Zhang, Hailin Zou, Huijing Ye, Yun Wang, Jing Zhang, Huasheng Yang, Jingxuan Pan

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma. (human colon organoid, PDX, NOG)
Gastroenterology. 2020 Feb;158(3):638-651.e8. doi: 10.1053/j.gastro.2019.10.009. Epub 2019 Oct 14.
Kawasaki K, Fujii M, Sugimoto S, Ishikawa K, Matano M, Ohta Y, Toshimitsu K, Takahashi S, Hosoe N, Sekine S, Kanai T, Sato T.

The SLAMF3 rs509749 polymorphism correlates with malignant potential in multiple myeloma. (Multiple myeloma, NOG)
Exp Hematol. 2020 Oct;90:72-79. doi: 10.1016/j.exphem.2020.08.006. Epub 2020 Aug 17.
Ishibashi M, Sunakawa-Kii M, Kaito Y, Kinoshita R, Asayama T, Kuribayashi Y, Inokuchi K, Morita R, Tamura H.

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection. (HIV, NOG)
J Vis Exp. 2020 Jan 31;(155). doi: 10.3791/60723.
Andersen AHF, Nielsen SSF, Olesen R, Mack K, Dagnæs-Hansen F, Uldbjerg N, Østergaard L, Søgaard OS, Denton PW, Tolstrup M.

Comparable human reconstitution following Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice. (NOG, comparable human reconstitution following cesium137 vs X-ray)
PLoS One. 2020 Oct 29;15(10):e0241375. doi:10.1371/journal.pone.0241375. eCollection 2020.
Andersen AHF, Nielsen SSF, Olesen R, Harslund JLF, Søgaard OS, Østergaard L, Denton PW, Tolstrup M.

Dasatinib exacerbates splenomegaly of mice inoculated with Epstein-Barr virus-infected lymphoblastoid cell lines. (EBV-LCLs, NOG)
Sci Rep. 2020 Mar 9;10(1):4355. doi: 10.1038/s41598-020-61300-y.
Kotaki R, Kawashima M, Yamamoto Y, Higuchi H, Nagashima E, Kurosaki N, Takamatsu M, Kikuti YY, Imadome KI, Nakamura N, Kotani A.

A long-acting 3TC ProTide nanoformulation suppresses HBV replication in humanized mice.(humanized mice, NOG, HBV replication)
Nanomedicine. 2020 Aug;28:102185. doi: 10.1016/j.nano.2020.102185. Epub 2020 Mar 24.
Wang W, Smith N, Makarov E, Sun Y, Gebhart CL, Ganesan M, Osna NA, Gendelman HE, Edagwa BJ, Poluektova LY.

Antioxidant Small Molecule Compound Chrysin Promotes the Self-Renewal of Hematopoietic Stem Cells.(humanized mice, NOG, Self-Renewal)
Front Pharmacol. 2020 Apr 2;11:399. doi: 10.3389/fphar.2020.00399. eCollection 2020.
Li Y, He M, Zhang W, Yang M, Ding Y, Xu S, Gu J, Li Y, Yin J, Gao Y.

Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms. (Human mesenchymal stem cells, humanized mice, GVHD, NOG)
World J Stem Cells. 2020 Sep 26;12(9):1032-1049. doi: 10.4252/wjsc.v12.i9.1032.
Song Y, Lim JY, Lim T, Im KI, Kim N, Nam YS, Jeon YW, Shin JC, Ko HS, Park IY, Cho SG.

Patient-derived xenograft (PDX) models: characteristics and points to consider for the process of establishment. (PDX, NOG)
J Toxicol Pathol. 2020 Jul;33(3):153-160. doi: 10.1293/tox.2020-0007. Epub 2020 Mar 20.
Etsuko Fujii, Atsuhiko Kato, Masami Suzuki

Nonclinical safety, tolerance and pharmacodynamics evaluation for meplazumab treating chloroquine-resistant Plasmodium falciparum.(ADA, ADCC, Plasmodium falciparum, humanized mice, NOG)
Acta Pharm Sin B. 2020 Sep;10(9):1680-1693. doi: 10.1016/j.apsb.2020.06.011. Epub 2020 Jun 30.
Zhang K, Zhao Y, Zhang Z, Zhang M, Wu X, Bian H, Zhu P, Chen Z.

Establishment of Humanized Mice from Peripheral Blood Mononuclear Cells or Cord Blood CD34+ Hematopoietic Stem Cells for Immune-Oncology Studies Evaluating New Therapeutic Agents. (Immune therapy, PBMC, HSC, humanized mice)
Curr Protoc Pharmacol. 2020 Jun;89(1):e77
Verma B, Wesa A.

Nonclinical safety, tolerance and pharmacodynamics evaluation for meplazumab treating chloroquine-resistant Plasmodium falciparum.(ADA, ADCC, Plasmodium falciparum, humanized mice, NOG)
Acta Pharm Sin B. 2020 Sep;10(9):1680-1693. doi: 10.1016/j.apsb.2020.06.011. Epub 2020 Jun 30.
Zhang K, Zhao Y, Zhang Z, Zhang M, Wu X, Bian H, Zhu P, Chen Z.

TNFSF15 facilitates human umbilical cord blood haematopoietic stem cell expansion by activating Notch signal pathway. (humanized mice, NOG, TNFSF15)
J Cell Mol Med. 2020 Oct;24(19):11146-11157. doi: 10.1111/jcmm.15626. Epub 2020 Sep 10.
Ding Y, Gao S, Shen J, Bai T, Yang M, Xu S, Gao Y, Zhang Z, Li L.

Antioxidant Small Molecule Compound Chrysin Promotes the Self-Renewal of Hematopoietic Stem Cells. (humanized mice, NOG, Self-Renewal)
Front Pharmacol. 2020 Apr 2;11:399. doi: 10.3389/fphar.2020.00399. eCollection 2020.
Li Y, He M, Zhang W, Yang M, Ding Y, Xu S, Gu J, Li Y, Yin J, Gao Y.

Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms. (Human mesenchymal stem cells, humanized mice, NOG )
World J Stem Cells. 2020 Sep 26;12(9):1032-1049. doi: 10.4252/wjsc.v12.i9.1032.
Song Y, Lim JY, Lim T, Im KI, Kim N, Nam YS, Jeon YW, Shin JC, Ko HS, Park IY, Cho SG.

2019

Comparison of biological features between severely immuno-deficient NOD/Shi-scid Il2rg null and NOD/LtSz-scidIl2rg null mice. (NOG, BG data)
Exp Anim. 2019 Nov 6;68(4):471-482. doi: 10.1538/expanim.19-0024. Epub 2019 May 21.
Mariko Nagatani, Tsutomu Kodera, Daisuke Suzuki, Saori Igura, Yachiyo Fukunaga, Hiroyuki Kanemitsu, Daichi Nakamura, Masahiro Mochizuki, Masayuki Kemi, Kazutoshi Tamura, Kenichiro Kasahara

Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone. (Bone metastases, humanized mice, NOG)
J Immunol Res. 2019 May 9;2019:4260987. doi: 10.1155/2019/4260987. eCollection 2019.
Kähkönen TE, Suominen MI, Mäki-Jouppila JHE, Halleen JM, Tanaka A, Seiler M, Bernoulli J.

MTBHsp70-exFPR1-pulsed Dendritic Cells Enhance the Immune Response against Cervical Cancer. (Cervical Cancer, Dendritic cells, NOG)
J Cancer. 2019 Oct 19;10(25):6364-6373. doi: 10.7150/jca.29779. eCollection 2019.
Cao G, Cui R, Liu C, Zhang G, Zhang Z.

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice.(Multiple myeloma, Bone Marrow Imaging, NOG)
J Vis Exp. 2019 Jan 7;(143):10.3791/58056. doi: 10.3791/58056.
Gastelum G, Chang EY, Shackleford D, Bernthal N, Kraut J, Francis K, Smutko V, Frost P.

Increased Granulopoiesis in the Bone Marrow following Epstein-Barr Virus Infection. (EBV, humanized mice, NOG)
Sci Rep. 2019 Sep 17;9(1):13445. doi: 10.1038/s41598-019-49937-w.
Katahira Y, Higuchi H, Matsushita H, Yahata T, Yamamoto Y, Koike R, Ando K, Sato K, Imadome KI, Kotani A.

Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy (Cancer immune therapy, NOG)
Nano Lett. 2019 May 8;19(5):2774-2783. doi: 10.1021/acs.nanolett.8b04296. Epub 2019 Apr 5.
Zhang YX, Zhao YY, Shen J, Sun X, Liu Y, Liu H, Wang Y, Wang J.

Inhibition of Notch Signaling Enhances Chemosensitivity in B-cell Precursor Acute Lymphoblastic Leukemia (B-cell Precursor Acute Lymphoblastic Leukemia, NOG).
Cancer Res. 2019 Feb 1;79(3):639-649. doi: 10.1158/0008-5472.CAN-18-1617. Epub 2018 Dec 18.
Takam Kamga P, Dal Collo G, Midolo M, Adamo A, Delfino P, Mercuri A, Cesaro S, Mimiola E, Bonifacio M, Andreini A, Chilosi M, Krampera M.

Abscopal effect when combining oncolytic adenovirus and checkpoint inhibitor in a humanized NOG mouse model of melanoma. (Cancer immunotherapy, humanized mice, NOG).
J Med Virol. 2019 Sep;91(9):1702-1706. doi: 10.1002/jmv.25501. Epub 2019 Jun 24.
Kuryk L, Møller AW, Jaderberg M.

Alloreactive T Cells Display a Distinct Chemokine Profile in Response to Conditioning in Xenogeneic GVHD Models.(GVHD models, NOG, NOG-ΔMHC)
Transplantation. 2019 Sep;103(9):1834-1843. doi:10.1097/TP.0000000000002756.
Kawasaki Y, Sato K, Nakano H, Hayakawa H, Izawa J, Takayama N, Mashima K, Oh I, Minakata D, Yamasaki R, Morita K, Ashizawa M, Yamamoto C, Hatano K, Fujiwara SI, Ohmine K, Muroi K, Ito R, Hayakawa M, Ohmori T, Kanda Y.

The Preconditioning of Busulfan Promotes Efficiency of Human CD133+ Cells Engraftment in NOD Shi-SCID IL2Rγcnull (NOG) Mice via Intra-Bone Marrow Injection. (CD133+ Cells engraftment, humanized mice, NOG)
Cell Transplant. 2019 Jul;28(7):973-979. doi: 10.1177/0963689719842162. Epub 2019 Apr 15.
Guo X, Yin X, Zhu W, Pan Y, Wang H, Liang Y, Zhu X

HTLV-1 Extracellular Vesicles Promote Cell-to-Cell Contact. (HTLV-1, humanized mice, NOG)
Front Microbiol. 2019 Sep 18;10:2147. doi: 10.3389/fmicb.2019.02147. eCollection 2019.
Pinto DO, DeMarino C, Pleet ML, Cowen M, Branscome H, Al Sharif S, Jones J, Dutartre H, Lepene B, Liotta LA, Mahieux R, Kashanchi F.

Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma.(Uveal melanoma, NOG)
Mol Cancer 2019 Sep 16;18(1):140. doi: 10.1186/s12943-019-1070-7.
Jing Zhang, Shenglan Liu, Qianyun Ye, Jingxuan Pan

Optimized Xenograft Protocol for Chronic Lymphocytic Leukemia Results in High Engraftment Efficiency for All CLL Subgroups. (CLL, NOG, BRG)
Int J Mol Sci. 2019 Dec 12;20(24):6277. doi: 10.3390/ijms20246277.
Sarah Decker, Anabel Zwick, Shifa Khaja Saleem, Sandra Kissel, Andres Rettig, Konrad Aumann, Christine Dierks

cAIMP administration in humanized mice induces a chimerization-level-dependent STING response. (humanized mice, NOG)
Immunology. 2019 Jun;157(2):163-172. doi: 10.1111/imm.13061. Epub 2019 May 6.
Andersen AHF, Olesen R, Jønsson KL, Højen JF, Krapp C, Mack K, Thomsen MK, Østergaard L, Tolstrup M, Dagnaes-Hansen F, Jakobsen MR, Denton PW.

Increased SLAMF7high monocytes in myelofibrosis patients harboring JAK2 V617F provide a therapeutic target of elotuzumab. (humanized mice, NOG, myelofibrosis, elotuzmab)
Blood. 2019 Sep 5;134(10):814-825. doi: 10.1182/blood.2019000051. Epub 2019 Jul 3.
Maekawa T, Kato S, Kawamura T, Takada K, Sone T, Ogata H, Saito K, Izumi T, Nagao S, Takano K, Okada Y, Tachi N, Teramoto M, Horiuchi T, Hikota-Saga R, Endo-Umeda K, Uno S, Osawa Y, Kobayashi A, Kobayashi S, Sato K, Hashimoto M, Suzu S, Usuki K, Morishita S, Araki M, Makishima M, Komatsu N, Kimura F.

CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis. (Liver cancer, CD73 function, NOG)
J Hematol Oncol. 2019 Apr 11;12(1):37. doi: 10.1186/s13045-019-0724-7.
Xiao-Lu Ma, Min-Na Shen, Bo Hu, Bei-Li Wang, Wen-Jing Yang, Li-Hua Lv, Hao Wang, Yan Zhou, An-Li Jin, Yun-Fan Sun, Chuan-Yan Zhang, Shuang-Jian Qiu, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo

Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit (humanized mice, NOG, Cancer Immune therapy)
MAbs. 2019 Nov-Dec;11(8):1443-1451. doi: 10.1080/19420862.2019.1654303. Epub 2019 Sep 3.
Jie Wang, Keke Fei, Hua Jing, Zhihai Wu, Weiwei Wu, Shuaixiang Zhou, Haiqing Ni, Bingliang Chen, Yan Xiong, Yanpeng Liu, Bo Peng, Dechao Yu, Haiping Jiang, Junjian Liu

2018

Tumorigenicity-associated characteristics of human iPS cell lines. (Tumorigenicity test, NOG)
PLoS One. 2018 Oct 4;13(10):e0205022. doi: 10.1371/journal.pone.0205022. eCollection 2018.
Satoshi Yasuda, Shinji Kusakawa, Takuya Kuroda, Takumi Miura, Keiko Tano, Nozomi Takada, Satoko Matsuyama, Akifumi Matsuyama, Michiyo Nasu, Akihiro Umezawa, Takao Hayakawa, Hideki Tsutsumi, Yoji Sato

Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions. (Cervical cancer)
Oncogenesis. 2018 Jan 23;7(1):4. doi: 10.1038/s41389-017-0018-2.
Zhang Q, Wang H, Li H, Xu J, Tian K, Yang J, Lu Z, Zheng J.

Development of the next generation humanized mouse for drug discovery (Next generation NOG, Japanese)
Nihon Yakurigaku Zasshi. 2018;151(4):160-165. doi: 10.1254/fpj.151.160.]
Ryoji Ito,

Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model.(Cancer immunotherapy )
Oncoimmunology. 2018 Apr 18;7(8):e1450715. doi: 10.1080/2162402X.2018.1450715. eCollection 2018.
Idorn M, Skadborg SK, Kellermann L, Halldórsdóttir HR, Holmen Olofsson G, Met Ö, Thor Straten P.

Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions (Lung cancer)
Cancer Sci. 2018 Oct;109(10):3149-3158. doi: 10.1111/cas.13752. Epub 2018 Sep 11.
Kato Y, Ninomiya K, Ohashi K, Tomida S, Makimoto G, Watanabe H, Kudo K, Matsumoto S, Umemura S, Goto K, Ichihara E, Ninomiya T, Kubo T, Sato A, Hotta K, Tabata M, Toyooka S, Maeda Y, Kiura K.

Immunologic targeting of CD30 eliminates tumorigenic human pluripotent stem cells, allowing safer clinical application of hiPSC-based cell therapy. (tumorigenic human pluripotent stem cells)
Sci Rep. 2018 Feb 27;8(1):3726. doi: 10.1038/s41598-018-21923-8.
Sougawa N, Miyagawa S, Fukushima S, Kawamura A, Yokoyama J, Ito E, Harada A, Okimoto K, Mochizuki-Oda N, Saito A, Sawa Y.

Combination of immunogenic oncolytic adenovirus ONCOS-102 with anti-PD-1 pembrolizumab exhibits synergistic antitumor effect in humanized A2058 melanoma huNOG mouse model (Cancer immune therapy).
Oncoimmunology. 2018 Oct29;8(2):e1532763. doi:10.1080/2162402X.2018.1532763. eCollection 2019.
Kuryk L, Møller AW, Jaderberg M.

High-sensitivity Detection of Micrometastases Generated by GFP Lentivirus-transduced Organoids Cultured from a Patient-derived Colon Tumor.
J Vis Exp. 2018 Jun 14;(136):57374. doi: 10.3791/57374.
Yu Okazawa, Kosuke Mizukoshi, Yu Koyama, Shoki Okubo, Hiromitsu Komiyama, Yutaka Kojima, Michitoshi Goto, Sonoko Habu, Okio Hino, Kazuhiro Sakamoto, Akira Orimo

Establishment of a Patient-Derived Tumor Xenograft Model and Application for Precision Cancer Medicine.
Chem Pharm Bull (Tokyo). 2018;66(3):225-230. doi: 10.1248/cpb.c17-00789.
Seiji Okada, KulthidaVaeteewoottacharn, Ryusho Kariya

Enhanced Antibody Responses in a Novel NOG Transgenic Mouse with Restored Lymph Node Organogenesis. (Antibody response)
Front Immunol. 2018 Jan 17;8:2017. doi: 10.3389/fimmu.2017.02017. eCollection 2017.
Takahashi T, Katano I, Ito R, Goto M, Abe H, Mizuno S, Kawai K, Sugiyama F, Ito M.

Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation.
Stem Cell Reports. 2018 Mar 13;10(3):1059-1074. doi: 10.1016/j.stemcr.2018.01.032. Epub 2018 Mar 1.
Iraha S, Tu HY, Yamasaki S, Kagawa T, Goto M, Takahashi R, Watanabe T, Sugita S, Yonemura S, Sunagawa GA, Matsuyama T, Fujii M, Kuwahara A, Kishino A, Koide N, Eiraku M, Tanihara H, Takahashi M, Mandai M.

Characterization of a new B-ALL cell line with constitutional defect of the Notch signaling pathway.(B-ALL)
Oncotarget. 2018 Apr 6;9(26):18341-18350. doi: 10.18632/oncotarget.24836.
Kamga PT, Dal Collo G, Bassi G, Midolo M, Delledonne M, Chilosi M, Bonifacio M, Krampera M.

Influence of the three-dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3.(osteogenesis)
J Tissue Eng Regen Med. 2018 Apr;12(4):e1936-e1949. doi: 10.1002/term.2625. Epub 2018 Jan 8.
Guerrero J, Oliveira H, Aid R, Bareille R, Siadous R, Letourneur D, Mao Y, Kohn J, Amédée J.

2017

Background data on NOD/Shi scid IL 2R γ null mice (NOG mice).
J Toxicol Sci. 2017;42(6):689-705. doi: 10.2131/jts.42.689.
Kenichiro Kasahara, Yachiyo Fukunaga, Saori Igura, Rie Andoh, Tsubasa Saito, Isamu Suzuki, Hiroyuki Kanemitsu Daisuke Suzuki, Ken Goto, Daichi Nakamura, Masahiro Mochizuki, Masahiko Yasuda, Ryo Inoue, Kazutoshi Tamura, Mariko Nagatani

Incidence of spontaneous lymphomas in non-experimental NOD/Shi-scid, IL-2Rγ null (NOG) mice.
Exp Anim. 2017 Oct 30;66(4):425-435. doi: 10.1538/expanim.17-0034. Epub 2017 Jul 6.
Masahiko Yasuda, Tomoyuki Ogura, Takayuki Goto, Mika Yagoto, Yoko Kamai, Chie Shimomura, Nobuhito Hayashimoto, Yukito Kiyokawa, Hideki Shinohara, Riichi Takahashi, Kenji Kawai

Chimeric antigen receptor-modified T Cells inhibit the growth and metastases of established tissue factor-positive tumors in NOG mice. (CAR-T)
Oncotarget. 2017 Feb 7;8(6):9488-9499. doi: 10.18632/oncotarget.14367.
Qing Zhang, Haiyu Wang, Huizhong Li, Jinjing Xu, Kang Tian, Jie Yang, Zheng Lu, Junnian Zheng

Irradiation strongly reduces tumorigenesis of human induced pluripotent stem cells. (Pluripotent stem cells, tumorigenesis)
J Radiat Res. 2017 Jul 1;58(4):430-438. doi: 10.1093/jrr/rrw124.
Inui S, Minami K, Ito E, Imaizumi H, Mori S, Koizumi M, Fukushima S, Miyagawa S, Sawa Y, Matsuura N.

MtHsp70-CLIC1-pulsed dendritic cells enhance the immune response against ovarian cancer. (Ovarian Cancer)
Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):13-19. doi: 10.1016/j.bbrc.2017.10.094. Epub 2017 Oct 20.
Yu W, Qu H, Cao G, Liu C, Deng H, Zhang Z.

Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma. (ATL)
Blood. 2017 Aug 31;130(9):1114-1124. doi: 10.1182/blood-2016-09-741983. Epub 2017 Jun 23.
Narita T, Ishida T, Ito A, Masaki A, Kinoshita S, Suzuki S, Takino H, Yoshida T, Ri M, Kusumoto S, Komatsu H, Imada K, Tanaka Y, Takaori-Kondo A, Inagaki H, Scholz A, Lienau P, Kuroda T, Ueda R, Iida S

Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. (ATL)
Cancer Sci. 2017 Mar;108(3):435-443. doi: 10.1111/cas.13163.
Nasu K, Yamaguchi K, Takanashi T, Tamai K, Sato I, Ine S, Sasaki O, Satoh K, Tanaka N, Tanaka Y, Fukushima T, Harigae H, Sugamura K.

Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/β-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. (CML)
Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
Jin B, Wang C, Li J, Du X, Ding K, Pan J.

Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts(CLL)
Oncotarget. 2017 Jul 4;8(27):44749-44760. doi: 10.18632/oncotarget.17432.
Davies NJ, Kwok M, Gould C, Oldreive CE, Mao J, Parry H, Smith E, Agathanggelou A, Pratt G, Taylor AMR, Moss P, Griffiths M, Stankovic T.

CD34 Antigen and the MPL Receptor Expression Defines a Novel Class of Human Cord Blood-Derived Primitive Hematopoietic Stem Cells.
Cell Transplant. 2017 Jun 9;26(6):1043-1058.
Yoshikazu Matsuoka, Masaya Takahashi, Keisuke Sumide, Hiroshi Kawamura, Ryusuke Nakatsuka, Tatsuya Fujioka, Yoshiaki Sonoda

Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model.
Nat Commun. 2017 Sep 27;8(1):707. doi: 10.1038/s41467-017-00786-z.
Jespersen H, Lindberg MF, Donia M, Söderberg EMV, Andersen R, Keller U, Ny L, Svane IM, Nilsson LM, Nilsson JA.

Humanized NOG mice as a model for tuberculosis vaccine-induced immunity: a comparative analysis with the mouse and guinea pig models of tuberculosis.
Immunology. 2017 Sep;152(1):150-162.
Ajay Grover, Amber Troy, Jenny Rowe, JoLynn M Troudt, Elizabeth Creissen, Jennifer McLean 1, Prabal Banerjee, Gerold Feuer, Angelo A Izzo

Human fetal liver cultures support multiple cell lineages that can engraft immunodeficient mice.
Open Biol. 2017 Dec;7(12):170108.
Marina E Fomin, Ashley I Beyer, Marcus O Muench

Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells.
Stem Cell Res. 2017 May;21:32-39.
Xuejia Li, Chengxiang Xia, Tongjie Wang, Lijuan Liu, Qianhao Zhao, Dan Yang, Fangxiao Hu, Mengyun Zhang, Ke Huang, Yang Geng, Yi Zheng, Yuxian Guan, Hongling Wu, Xiaoli Chen, Guangjin Pan, Jiekai Chen, Juan Du, Jinyong Wang

Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/β-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia.
Clin Cancer Res. 2017 Feb 1;23(3):789-803.
Bei Jin, Chengyan Wang, Juan Li, Xin Du, Ke Ding, Jingxuan Pan

Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts.
Oncotarget . 2017 Jul 4;8(27):44749-44760. doi: 10.18632/oncotarget.17432.
Nicholas J Davies, Marwan Kwok, Clive Gould, Ceri E Oldreive, Jingwen Mao, Helen Parry, Edward Smith, Angelo Agathanggelou, Guy Pratt, Alexander Malcolm R Taylor, Paul Moss, Mike Griffiths, Tatjana Stankovic

Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model.
Nat Commun . 2017 Sep 27;8(1):707. doi: 10.1038/s41467-017-00786-z.
Henrik Jespersen, Mattias F Lindberg, Marco Donia, Elin M V Söderberg, Rikke Andersen, Ulrich Keller, Lars Ny, Inge Marie Svane, Lisa M Nilsson, Jonas A Nilsson

Comparison of the Gene Expression Profiles of Human Hematopoietic Stem Cells between Humans and a Humanized Xenograft Model.
Tokai J Exp Clin Med. 2017 Apr 20;42(1):41-51.
Hideyuki Matsuzawa, Hiromichi Matsushita, Takashi Yahata, Masayuki Tanaka, Kiyoshi Ando

A Novel Xenogeneic Graft-Versus-Host Disease Model for Investigating the Pathological Role of Human CD4 + or CD8 + T Cells Using Immunodeficient NOG Mice. (GVHD model)
Am J Transplant. 2017 May;17(5):1216-1228. doi: 10.1111/ajt.14116. Epub 2016 Dec 21.
Ito R, Katano I, Kawai K, Yagoto M, Takahashi T, Ka Y, Ogura T, Takahashi R, Ito M.

Proliferative Cartilaginous Lesions in the Calcaneal Tendons of huNOG Mice. (NOG pathology)
Toxicol Pathol. 2017 Oct;45(7):952-956. doi: 10.1177/0192623317734822. Epub 2017 Oct 3.
MacLeod AM, Treuting PM, Carlson CS.

Comparison of the Gene Expression Profiles of Human Hematopoietic Stem Cells between Humans and a Humanized Xenograft Model. (humanized mice, gene expression)
Tokai J Exp Clin Med. 2017 Apr 20;42(1):41-51.
Matsuzawa H, Matsushita H, Yahata T, Tanaka M, Ando K.

Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells.
Stem Cell Res. 2017 May;21:32-39. doi: 10.1016/j.scr.2017.03.014. Epub 2017 Mar 21.
Li X, Xia C, Wang T, Liu L, Zhao Q, Yang D, Hu F, Zhang M, Huang K, Geng Y, Zheng Y, Guan Y, Wu H, Chen X, Pan G, Chen J, Du J, Wang J.

Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. (ATL derived cells)
Cancer Sci. 2017 Mar;108(3):435-443. doi: 10.1111/cas.13163.
Nasu K, Yamaguchi K, Takanashi T, Tamai K, Sato I, Ine S, Sasaki O, Satoh K, Tanaka N, Tanaka Y, Fukushima T, Harigae H, Sugamura K.

Chimeric antigen receptor-modified T Cells inhibit the growth and metastases of established tissue factor-positive tumors in NOG mice.
Oncotarget. 2017 Feb 7;8(6):9488-9499. doi: 10.18632/oncotarget.14367.
Qing Zhang, Haiyu Wang, Huizhong Li, Jinjing Xu, Kang Tian, Jie Yang, Zheng Lu, Junnian Zheng

2016

A Novel Carcinoembryonic Antigen T Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors. (T Cell Bispecific Antibody )
Clin Cancer Res. 2016 Jul 1;22(13):3286 97. doi: 10.1158/1078 0432.CCR 15 1696. Epub 2016 Feb 9.
Marina Bacac, Tanja Fauti, Johannes Sam, Sara Colombetti, Tina Weinzierl, Djamila Ouaret, Walter Bodmer, Steffi Lehmann, Thomas Hofer, Ralf J Hosse, Ekkehard Moessner, Oliver Ast, Peter Bruenker, Sandra Grau-Richards, Teilo Schaller, Annette Seidl, Christian Gerdes, Mario Perro, Valeria Nicolini, Nathalie Steinhoff, Sherri Dudal, Sebastian Neumann, Thomas von Hirschheydt, Christiane Jaeger, Jose Saro , Vaios Karanikas, Christian Klein, Pablo Umaña

Murine Models of Epstein-Barr Virus-Associated Lymphomagenesis. (EBV)
ILAR J. 2016;57(1):55-62. doi: 10.1093/ilar/ilv074.
Ahmed EH, Baiocchi RA.

h-prune affects anaplastic thyroid cancer invasion and metastasis. (Thyroid cancer metastasis)
Oncol Rep. 2016 Jun;35(6):3445-52. doi: 10.3892/or.2016.4759. Epub 2016 Apr 20.
Nambu J, Kobayashi T, Hashimoto M, Tashiro H, Sugino K, Shimamoto F, Kikuchi A, Ohdan H.

Development of DS-5573a: A novel afucosylated mAb directed at B7-H3 with potent antitumor activity.(Anti tumor)
Cancer Sci. 2016 May;107(5):674-81. doi: 10.1111/cas.12915. Epub 2016 Apr 26.
Nagase-Zembutsu A, Hirotani K, Yamato M, Yamaguchi J, Takata T, Yoshida M, Fukuchi K, Yazawa M, Takahashi S, Agatsuma T.

Sensitive Tumorigenic Potential Evaluation of Adult Human Multipotent Neural Cells Immortalized by hTERT Gene Transduction. (tumorigeneici test)
PLoS One. 2016 Jul 8;11(7):e0158639. doi:10.1371/journal.pone.0158639. eCollection 2016.
Lee KH, Nam H, Jeong da E, Kim SS, Song HJ, Pyeon HJ, Kang K, Hong SC, Nam DH, Joo KM.

Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation.(ATL).
Cancer Sci. 2016 May;107(5):638-43. doi: 10.1111/cas.12921. Epub 2016 Apr 7.
Yamaguchi K, Takanashi T, Nasu K, Tamai K, Mochizuki M, Satoh I, Ine S, Sasaki O, Satoh K, Tanaka N, Harigae H, Sugamura K.

Efficient Regeneration of Human Vα24 + Invariant Natural Killer T Cells and Their Anti-Tumor Activity In Vivo. (NKT, anti-tumor activity )
Stem Cells. 2016 Dec;34(12):2852-2860. doi: 10.1002/stem.2465. Epub 2016 Aug 1.
Yamada D, Iyoda T, Vizcardo R, Shimizu K, Sato Y, Endo TA, Kitahara G, Okoshi M, Kobayashi M, Sakurai M, Ohara O, Taniguchi M, Koseki H, Fujii SI.

Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with Imatinib(CML)
Theranostics. 2016 Aug 12;6(11):1947-62. doi: 10.7150/thno.16139. eCollection 2016.
Jin Y, Yao Y, Chen L, Zhu X, Jin B, Shen Y, Li J, Du X, Lu Y, Jiang S, Pan J.

Histone modifications patterns in tissues and tumours from acute promyelocytic leukemia xenograft model in response to combined epigenetic therapy (acute promyelocytic leukemia)
Biomed Pharmacother. 2016 Apr;79:62-70. doi: 10.1016/j.biopha.2016.01.044. Epub 2016 Feb 16.
Valiulienė G, Treigytė G, Savickienė J, Matuzevičius D, Alksnė M, Jarašienė-Burinskaja R, Bukelskienė V, Navakauskas D, Navakauskienė R.

Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. (EBV).
Oncotarget. 2016 Nov 22;7(47):76793-76805. doi: 10.18632/oncotarget.12529.
Ando S, Kawada JI, Watanabe T, Suzuki M, Sato Y, Torii Y, Asai M, Goshima F, Murata T, Shimizu N, Ito Y, Kimura H.

Antitumor effects of minodronate, a third-generation nitrogen-containing bisphosphonate, in synergy with γδT cells in human glioblastoma in vitro and in vivo. (glioblastoma).
J Neurooncol. 2016 Sep;129(2):231-41. doi: 10.1007/s11060-016-2186-x. Epub 2016 Jul 8.
Nakazawa T, Nakamura M, Matsuda R, Nishimura F, Park YS, Motoyama Y, Hironaka Y, Nakagawa I,

Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells. (Lung cancer).
Biochem Biophys Res Commun. 2016 Apr 22;473(1):125-132. doi:10.1016/j.bbrc.2016.03.064. Epub 2016 Mar 17.
Kobayashi I, Takahashi F, Nurwidya F, Nara T, Hashimoto M, Murakami A, Yagishita S, Tajima K, Hidayat M, Shimada N, Suina K, Yoshioka Y, Sasaki S, Moriyama M, Moriyama H, Takahashi K.

Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with Imatinib.
Theranostics. 2016 Aug 12;6(11)
Yanli Jin, Yiwu Yao, Li Chen, Xiaohui Zhu, Bei Jin, Yingying Shen, Juan Li, Xin Du, Yuhong Lu, Sheng Jiang, Jingxuan Pan

A Novel Carcinoembryonic Antigen T Cell Bispecific Antibody (CEA TCB) For The Treatment Of Solid Tumors.
Clin Cancer Res. 2016 Jul 1;22(13):3286-97. doi: 10.1158/1078-0432.CCR-15-1696. Epub 2016 Feb 9.
Bacac M, Fauti T, Sam J, Colombetti S, Weinzierl T, Ouaret D, Bodmer WF, Lehmann S, Hofer T, Hosse RJ, Moessner E, Ast O, Bruenker P, Grau-Richards S, Schaller T, Seidl A, Gerdes CA, Perro M, Nicolini V, Steinhoff N, Dudal S, Neumann S, von Hirschheydt T, Jaeger C, Saro J, Karanikas V, Klein C, Umana P.

Establishment and characterisation of patient-derived xenografts as paraclinical models for gastric cancer.
Sci Rep. 2016 Mar 1;6:22172. doi: 10.1038/srep22172.
Yoon Young Choi, Jae Eun Lee, Hyunki Kim, Moon Hee Sim, Ka-Kyung Kim, Gunho Lee, Hyoung-Il Kim, Ji Yeong An, Woo Jin Hyung, Choong-Bai Kim, Sung Hoon Noh, Sangwoo Kim, Jae-Ho Cheong

Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines. (humanized mice, Donor Dependent Variations, ES, iPS, MSC)
PLoS One. 2016 Mar 3;11(3):e0149291. doi: 10.1371/journal.pone.0149291. eCollection 2016.
Féraud O, Valogne Y, Melkus MW, Zhang Y, Oudrhiri N, Haddad R, Daury A, Rocher C, Larbi A, Duquesnoy P, Divers D, Gobbo E, Brunet de la Grange P, Louache F, Bennaceur-Griscelli A, Mitjavila-Garcia MT.

Heat Shock Enhances the Expression of the Human T Cell Leukemia Virus Type-I (HTLV-I) Trans-Activator (Tax) Antigen in Human HTLV-I Infected Primary and Cultured T Cells. (HTLV-1)
Viruses. 2016 Jul 11;8(7):191. doi: 10.3390/v8070191.
Kunihiro M, Fujii H, Miyagi T, Takahashi Y, Tanaka R, Fukushima T, Ansari AA, Tanaka Y.

A Potential of an Anti-HTLV-I gp46 Neutralizing Monoclonal Antibody (LAT-27) for Passive Immunization against Both Horizontal and Mother-to-Child Vertical Infection with Human T Cell Leukemia Virus Type-I. (HTLV-1)
Viruses. 2016 Feb 3;8(2):41. doi: 10.3390/v8020041.
Fujii H, Shimizu M, Miyagi T, Kunihiro M, Tanaka R, Takahashi Y, Tanaka Y.

Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines. (humanized mice, Donor Dependent Variations, ES, iPS, MSC, NOG)
PLoS One. 2016 Mar 3;11(3):e0149291. doi: 10.1371/journal.pone.0149291. eCollection 2016.
Féraud O, Valogne Y, Melkus MW, Zhang Y, Oudrhiri N, Haddad R, Daury A, Rocher C, Larbi A, Duquesnoy P, Divers D, Gobbo E, Brunet de la Grange P, Louache F, Bennaceur-Griscelli A, Mitjavila-Garcia MT.

2015

Early development of human lymphomas in a prostate cancer xenograft program using triple knock out immunocompromised mice. (Prostate cancer, PDX)
Prostate. 2015 May;75(6):585 92. doi: 10.1002/pros.22939. Epub 2015 Jan 13.
Christian Wetterauer, Tatjana Vlajnic, Julia Schüler, Joel R Gsponer, George N Thalmann, Marco Cecchini, Julia Schneider, Tobias Zellweger, Heike Pueschel, Alexander Bachmann, Christian Ruiz, Stephan Dirnhofer, Lukas Bubendorf, Cyrill A Rentsch

The status of donor cancer tissues affects the fate of patient-derived colorectal cancer xenografts in NOG mice. (PDX, colorectal cancer )
Exp Anim. 2015;64(2):181-90. doi: 10.1538/expanim.14-0080. Epub 2015 Jan 26.
Etsuko Fujii, Atsuhiko Kato, Yu Jau Chen, Koichi Matsubara, Yasuyuki Ohnishi, Masami Suzuki

Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia. (ATL)
Retrovirology. 2015 Nov 24;12:99. doi: 10.1186/s12977-015-0225-x.
Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T.

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry. (Cancer cells, imaging)
Nitric Oxide. 2015 Apr 30;46:102-13. doi: 10.1016/j.niox.2014.11.005. Epub 2014 Nov 11.
Mitsuyo Ohmura, Takako Hishiki, Takehiro Yamamoto, Tsuyoshi Nakanishi, Akiko Kubo, Kenji Tsuchihashi, Mayumi Tamada, Sakino Toue, Yasuaki Kabe, Hideyuki Saya, Makoto Suematsu

CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody.(ADCC, ADCP).
Cancer Sci. 2015 Oct;106(10):1474-8. doi: 10.1111/cas.12738.
Hiramatsu K, Serada S, Kobiyama K, Nakagawa S, Morimoto A, Matsuzaki S, Ueda Y, Fujimoto M, Yoshino K, Ishii KJ, Enomoto T, Kimura T, Naka T.

Evaluation of in vivo antitumor effects of ANT2 shRNA delivered using PEI and ultrasound with microbubbles. (shRNA Antitumor effects)
Gene Ther. 2015 Apr;22(4):325-32. doi: 10.1038/gt.2014.120. Epub 2015 Jan 15.
Park DH, Jung BK, Lee YS, Jang JY, Kim MK, Lee JK, Park H, Seo J, Kim CW.

Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype. (HIV1)
J Virol. 2015 Sep;89(17):9080-9. doi: 10.1128/JVI.00983-15. Epub 2015 Jun 24.
Shigemura T, Shiohara M, Kato M, Furuta S, Kaneda K, Morishita K, Hasegawa H, Fujii M, Gorlach A, Koike K, Kamata T.

Preclinical pharmacologic evaluation of pralatrexate and romidepsin confirms potent synergy of the combination in a murine model of human T-cell lymphoma (T cell lymphoma).
Clin Cancer Res. 2015 May 1;21(9):2096-106. doi: 10.1158/1078-0432.CCR-14-2249. Epub 2015 Feb 12.
Jain S, Jirau-Serrano X, Zullo KM, Scotto L, Palermo CF, Sastra SA, Olive KP, Cremers S, Thomas T, Wei Y,

Common marmoset CD117+ hematopoietic cells possess multipotency.
Int Immunol. 2015 Nov;27(11):567-77.
Shin Shimada, Satoshi Nunomura, Shuya Mori, Hiroshi Suemizu, Toshio Itoh, Shuji Takabayashi, Yoshinori Okada, Takashi Yahata, Takashi Shiina, Hideki Katoh, Ryuji Suzuki, Kenzaburo Tani, Kiyoshi Ando, Hideo Yagita, Sonoko Habu, Erika Sasaki, Yoshie Kametani

Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.
PLoS One. 2015 Jul 10;10(7):e0132041.
Changshan Wang, Motohiko Oshima, Goro Sashida, Takahisa Tomioka, Nagisa Hasegawa, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Yoichiro Kusunoki, Seishi Kyoizumi, Kazue Imai, Kei Nakachi, Atsushi Iwama

Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes.
PLoS One. 2015 Sep 1;10(9):e0136851. doi: 10.1371/journal.pone.0136851. eCollection 2015.
McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F.

Committing Cytomegalovirus-Specific CD8 T Cells to Eliminate Tumor Cells by Bifunctional Major Histocompatibility Class I Antibody Fusion Molecules.
Cancer Immunol Res. 2015 Jul;3(7):764-76. doi: 10.1158/2326-6066.CIR-15-0037. Epub 2015 Feb 17.
Schmittnaegel M, Levitsky V, Hoffmann E, Georges G, Mundigl O, Klein C, Knoetgen H.

CEA TCB, A novel T-cell bispecific antibody with potent in vitro and in vivo antitumour activity against solid tumours.
European Journal of CancerVolume 51, Supplement 1,March 2015, Page S13
Bacac M, Fauti T, Colombetti S, Sam J, Nicolini V, Steinhoff N, Ast O, Bruenker P, Hosse R, Hofer T, Moessner E, Jaeger C, Saro J, Karanikas V, Klein C, Umana P.

Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia.
Retrovirology. 2015 Nov 24;12:99. doi: 10.1186/s12977-015-0225-x.
Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T.

The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells.
Cancers (Basel). 2015 May 22;7(2):876-907. doi: 10.3390/cancers7020814.
Gomez-Casal R, Bhattacharya C, Epperly MW, Basse PH, Wang H, Wang X, Proia DA, Greenberger JS, Socinski MA, Levina V.

Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells.
J Virol. 2015 Jul;89(14):7016-27. doi: 10.1128/JVI.00716-15. Epub 2015 Apr 29.
Kondo Y, Kimura O, Tanaka Y, Ninomiya M, Iwata T, Kogure T, Inoue J, Sugiyama M, Morosawa T, Fujisaka Y, Shimosegawa T.

Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia.
Retrovirology. 2015 Nov 24;12:99. doi: 10.1186/s12977-015-0225-x.
Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T.

Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.
J Pharmacol Exp Ther. 2015 Mar;352(3):579-89. doi:10.1124/jpet.114.221150. Epub 2015 Jan 9.
Rudolph D, Impagnatiello MA, Blaukopf C, Sommer C, Gerlich DW, Roth M, Tontsch-Grunt U, Wernitznig A, Savarese F, Hofmann MH, Albrecht C, Geiselmann L, Reschke M, Garin-Chesa P, Zuber J, Moll J, Adolf GR, Kraut N.

Osteopontin integrin interaction as a novel molecular target for antibody mediated immunotherapy in adult T cell leukemia.
Retrovirology. 12:99 .
Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T.

Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.
J Pharmacol Exp Ther. 352(3):579-89.
Rudolph D, Impagnatiello MA, Blaukopf C, Sommer C, Gerlich DW, Roth M, Tontsch-Grunt U, Wernitznig A, Savarese F, Hofmann MH, Albrecht C, Geiselmann L, Reschke M, Garin-Chesa P, Zuber J, Moll J, Adolf GR, Kraut N.

Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity.
J Immunol. 2015 Jul 13. pii: 1402103. [Epub ahead of print]
Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M.

MicroRNA-16 mediates the regulation of a senescence-apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas.
Oncogenem advance online publication, 7 Dec 2015 (doi: 10.1038/onc.2015.435).
Kitadate A, Ikeda S, Teshima K, Ito M, Toyota I, Hasunuma N, Takahashi N, Miyagaki T, Sugaya M, Tagawa H.

Early development of human lymphomas in a prostate cancer xenograft program using triple knock-out immunocompromised mice.
Prostate. 2015 May;75(6):585-92. doi: 10.1002/pros.22939. Epub 2015 Jan 13.
Christian Wetterauer 1, Tatjana Vlajnic, Julia Schüler, Joel R Gsponer, George N Thalmann, Marco Cecchini, Julia Schneider, Tobias Zellweger, Heike Pueschel, Alexander Bachmann, Christian Ruiz, Stephan Dirnhofer, Lukas Bubendorf, Cyrill A Rentsch

Spontaneous Post-Transplant Disorders in NOD.Cg- Prkdcscid Il2rgtm1Sug /JicTac (NOG) Mice Engrafted with Patient-Derived Metastatic Melanomas.
https://doi.org/10.1371/journal.pone.0124974
Enrico Radaelli, Els Hermans, Lorna Omodho, Annick Francis, Sara Vander Borght, Jean-Christophe Marine, Joost van den Oord, Frédéric Amant

The status of donor cancer tissues affects the fate of patient-derived colorectal cancer xenografts in NOG mice.
Exp Anim. 2015;64(2):181-90. doi: 10.1538/expanim.14-0080. Epub 2015 Jan 26.
Etsuko Fujii, Atsuhiko Kato, Yu Jau Chen, Koichi Matsubara, Yasuyuki Ohnishi, Masami Suzuki

Establishment of patient-derived cancer xenografts in immunodeficient NOG mice.
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Human Atopic Dermatitis Skin-derived T Cells can Induce a Reaction in Mouse Keratinocytes in vivo.
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Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells.
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Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.
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The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice. (Hapatitis BV)
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Characterization of in vivo tumorigenicity tests using severe immunodeficient NOD/Shi-scid IL2Rγ null mice for detection of tumorigenic cellular impurities in human cell-processed therapeutic products. (Tumorigenicity test)
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Visualization of the human CD4⁺ T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/γc(null) (NOG) mice by retrogenic expression of the human TCR gene. (HLA-DR4-NOG)
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Human Atopic Dermatitis Skin-derived T Cells can Induce a Reaction in Mouse Keratinocytes in vivo. (Atopic dermatitis)
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Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/ progenitor cells in vitro (mouse dental pulp stem cells)
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Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells. (HBV)
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Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity. (Innate response to human cancer)
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Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro.
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Ryusuke Nakatsuka, Yoshikazu Matsuoka, Yasushi Uemura, Keisuke Sumide, Ryuji Iwaki, Masaya Takahashi, Tatsuya Fujioka, Yutaka Sasaki, Yoshiaki Sonoda