系統名(カルタヘナ情報) | マウス NOG-hIL-15 Tg |
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系統名(略称) | NOG-IL15 マウス |
CMVモーター下流にヒトIL-15遺伝子を配置したベクターを(NOD♀ x NOG♂)F1 前核期受精卵へマイクロインジェクションしてファウンダーマウスを得た後、NOGマウスと戻し交配して樹立しました。
NOG-IL15 マウスの開発経緯、およびヒトNK細胞を移入したNOG-IL15 マウスの特徴、主な研究用途をご紹介します。
Vδ2 T-cell engagers bivalent for Vδ2-TCR binding provide anti-tumor immunity and support robust Vγ9Vδ2 T-cell expansion.(Vγ9Vδ2 T-cells; bispecific T-cell engager; cancer; expansion; immunotherapy; single domain antibody; NOG-IL15 mouse)
Front Oncol. 2024 Oct 18:14:1474007. doi: 10.3389/fonc.2024.1474007. eCollection 2024.
King LA, de Jong M, Veth M, Lutje Hulsik D, Yousefi P, Iglesias-Guimarais V, van Helden PM, de Gruijl TD, van der Vliet HJ.Bispecific immune cell engager enhances the anticancer activity of CD16+ NK cells and macrophages in vitro, and eliminates cancer metastasis in NK humanized NOG mice.(antibodies, bispecific; cytotoxicity; immunologic; NOG mouse; NOG-IL15 mouse; NOG-IL2 mouse)
J Immunother Cancer. 2024 Mar 15;12(3):e008295. doi: 10.1136/jitc-2023-008295.
Shahryar Khoshtinat Nikkhoi, Ge Yang, Hajar Owji, Mayara Grizotte-Lake, Rick I Cohen, Lazaro Gil Gonzalez, Mohammad Massumi, Arash HatefiDevelopment of Humanized Mouse Models for Studying Human NK Cells in Health and Disease.(humanized mice, NOG-IL15, NK cells)
Methods Mol Biol. 2022;2463:53-66. doi: 10.1007/978-1-0716-2160-8_5.
Shan L, Flavell RA, Herndler-Brandstetter D.Ruxolitinib, a JAK1/JAK2 selective inhibitor, ameliorates acute and chronic steroid-refractory GvHD mouse models. (humanized mice, NOG-IL15, NK cell, GVHD)
Immunotherapy. 2021 Aug;13(12):977-987. doi: 10.2217/imt-2021-0013. Epub 2021 Jun 29.
Huarte E, Peel M, Juvekar A, Dubé P, Sarah S, Stephens L, Stewart B, Long B, Czerniak P, Oliver J, Smith P.Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse. (NOG-IL15,NK cell mediated ADCC)
Front Immunol. 2020 Oct 7;11:532684. doi: 10.3389/fimmu.2020.532684. eCollection 2020.
Katano I, Ito R, Kawai K, Takahashi T.Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse. (Original, NOG-IL15, NK cell, ADCC, CTL)
Sci Rep. 2017 Dec 8;7(1):17230. doi: 10.1038/s41598-017-17442-7.
Katano I, Nishime C, Ito R, Kamisako T, Mizusawa T, Ka Y, Ogura T, Suemizu H, Kawakami Y, Ito M, Takahashi T.