重度免疫不全 NOG マウス

系統名（カルタヘナ情報）	マウス NOD/Shi-scid, IL-2RγKO Jic
系統名（略称）	NOGマウス

• ご購入にあたりまして使用同意書へのご署名が必要となります。
• またこのマウスモデルのご使用はカルタヘナ法の研究開発に係る遺伝子組み換え生物等にあたります。
  弊社より情報提供書をお送りいたしますので、ご確認のうえ各機関のルールに従ってご使用ください。
• NOGマウスは、日本国内で生産しお届けします。
• NOGマウスをご購入後、お客様の施設で臍帯血由来造血幹細胞（HSC）を移入し、
  ヒト化マウスを作製使用することが可能です。
• 妊娠マウスでの納品が可能です。

ご注文 お問い合わせ Q＆A集 技術情報・セミナーのご案内

開発

（公財）実験動物中央研究所の伊藤 守 博士により開発された重度免疫不全マウスです。
数種のサイトカインレセプター共通ドメインである IL-2レセプターγ鎖ノックアウト（IL2RγKO）マウス（Ohbo K et al., Blood 1996）とNOD-scidマウスを組み合わせることにより、極めて重度な複合型免疫不全を呈するNOG（NOD/Shi-scid, IL-2Rγnull）マウスを開発しました （Blood 2002）。

特徴

ヒト細胞/組織の生着性が他の免疫不全マウスと比べ著しく高く、ヒトがんやヒト正常組織を高率に生着させることが可能です。またヒト造血幹細胞移入後に、SCIDやヌードマウスでは観察されなかった、ヒトT細胞の分化が認められることから、ヒト免疫系モデルマ ウスとして有用と考えられ、需要が急速に高まってきています。

■ 以下の表現型を発現します。

• T、B細胞の欠失
• ナチュラルキラー（NK）細胞の欠失
• 樹状細胞の機能低下
• マクロファージの機能低下
• 補体活性の欠失
• 老化に伴うT, B細胞leakinessは認められません

研究用途

• ヒト化マウスモデル：ヒト造血系・免疫系モデル
• ヒト担癌モデル：ヒトPDX担癌モデル、ヒト血液がん担癌モデルなど
• ヒトPDX作製用マウス：患者由来新鮮腫瘍を最初に移植し、PDX腫瘍を作製する際の担癌用マウス
• ヒト感染症モデル：EBV、HIV、HTLV1、結核菌など
• GVHDモデル
• 再生医療製品の移植実験モデル：人工血液や心筋シートなど再生医療製品の移植実験モデルなど
• 再生医療製品等の造腫瘍性試験
• 抗体医薬品、二重特異性抗体による抗腫瘍性試験評価In vivoモデル
• 担癌後のCAR-TやTCR-T細胞療法のIn vivo 実験モデル
• 【関連文献】
  論文１ 論文２ 論文３
研究分野別系統一覧
再生医療研究に有用な重度免疫不全マウス

第83回日本癌学会発表ポスター（修正版）
・肺腺癌PDX由来新規細胞株の生物学的特性とその応用

背景データ

• NOG 体重推移
• NOG 血液性状
• NOG 器官重量
• NOG HeLa細胞生着能（造腫瘍性試験参考資料）
• NOG PDX腫瘍移植例
• NOG 長期飼育試験
• 実験動物中央研究所のPDX腫瘍およびPDX担癌モデルに関するページ

生産と供給

• 日本クレア株式会社に生産を委託し、日本国内で生産しています。
• AAALAC認証を含む国内第三者認証をうけた生産施設で生産しています。
  日本クレア株式会社動物福祉への取り組みはこちら
• 動物の輸送は、温度管理された専用車両により行います。

NOGマウスの文献集

文献集へ

ヒト化 NOG マウス

• ヒト造血幹細胞（HSC）および末梢血単核細胞（PBMC）を移入したモデルが汎用されています。
• 弊社は、日本国内でヒト化NOGマウスを作製し、お客様にお届けしています。
• 生産は、ご注文をいただいた後開始します。通常は受注約12週間後に出荷しています。
• また、ヒト化NOGマウスに担がんしたモデルを使用した薬効試験を受託いたします（注1） 。
• CAR-Tなどお客様が提供される細胞を移入して作製したモデルを使った受託試験も可能です。
• ご購入にあたりまして使用同意書へのご署名が必要となります。
• またこのマウスモデルのご使用はカルタヘナ法の研究開発に係る遺伝子組み換え生物等にあたります。
  弊社より情報提供書をお送りいたしますので、ご確認のうえ各機関のルールに従ってご使用ください。

（注1）通常、がん細胞株（またはPDX腫瘍）はお客様に準備していただいておりますが、購入可能な細胞の場合は弊社で購入することも可能です。

ご注文 お問い合わせ ヒト化マウス作製方法 技術情報・セミナーのご案内

ヒト造血幹細胞（HSC）移入ヒト化NOGマウスの特徴

• HSCを移入しますと、幹細胞は主にヒトT細胞とヒトB細胞に分化、生着します。一部はNK細胞、マクロファージ、単球にも分化しますが極少数です。（注2）
• ヒト化したマウスは移入後6ヶ月以上生存することが確認されています。ヒト免疫細胞の生着率も幹細胞移入後20週までほぼ変わらないことが確認されています。
• ヒト免疫細胞による移植片対宿主病（graft versus host disease; GVHD）は通常見られません。ヒト免疫細胞生着後にがん細胞を移植しても多くの場合、生着することが確認されています。
• 分化したヒトT細胞は、薬物やサイトカインによる活性化およびがん細胞等に対する細胞傷害活性が確認されています。
• 分化したヒトB細胞は抗原特異的なIgMを生産します。（注3）
• 米国、EU諸国ではTACONIC社が免疫系ヒト化NOGマウスを供給しています。
• 日本国内で供給されるヒト化マウスと同等の品質基準のものです。

（注2）通常出荷時のヒト免疫細胞は、主にT細胞とB細胞で構成されています。マウス由来のマクロファージは存在します。

（注3）DNP-KLH, Ovalubumineを免疫した場合、抗原に特異的なIgMが生産された実績があります。

HSC移入ヒト化NOGマウスの研究用途例

• がん免疫治療モデル：ヒト免疫系細胞とヒトがんを同時に持つモデルで、免疫チェックポイント阻害剤やがんワクチンを評価するモデル
• ヒト特異的ウイルス感染症モデル：EBウイルス、ヒト免疫不全ウイルス（HIV）、ヒト成人T細胞白血病ウイルス （HTLV1）などを感染させたモデル
• アレルギーモデル：抗原、抗体、サイトカインの投与によるヒト免疫系を介したアレルギーモデル
• ヒト化マウスの特徴、ヒト化マウス作製及び使用実験プロトコールに関しまして、詳細な説明会をオンラインを通して提供させていただいております。ご希望のお客様は、こちらまでお気軽にご連絡をいただけますようお願い申し上げます。

HSC移入NOGマウス背景データ

• HSC移入ヒト化NOGマウスにおけるhCD45陽性細胞の比率
• HSC移入ヒト化マウス作製方法

HSC移入NOGマウスの動画

HSC-NOGマウス（ヒト化マウス）の作製法、特徴、主な研究用途をご紹介します。

動画を見る

PBMC移入ヒト化NOGマウスの特徴

• ヒト末梢血単核球細胞（PBMC)を移入します。
• ヒトCD3+ T細胞が良く生着し、CD4+ T細胞・CD8+ T細胞も認められています。
• 移入後2-3週で末梢血中にT細胞が検出され、脾臓・肺・肝臓などにも多くのT細胞が浸潤しています。
• PBMCのロットにより移入率は異なりますが、ほぼ20%以上のヒト細胞が定着します。
• PBMCを1×107個移入しますと、移入3週間ほどでGVHDを発症し、1～2ヶ月程度で死亡します。長期に亘る実験を実施する場合、GVHDの発症を抑制したNOG-ΔMHCマウスを選択できます。

PBMC移入ヒト化NOGマウスの研究用途

• GVHDモデル
• 拒絶反応モデル
• 短期のHIVウイルス感染モデル
• ヒト化マウスの特徴、ヒト化マウス作製及び使用実験プロトコールに関しまして、詳細な説明会をオンラインを通して提供させていただいております。ご希望をのお客様は、こちらまでお気軽にご連絡をいただけますようお願い申し上げます。

研究分野別系統一覧

再生医療研究に有用な重度免疫不全マウス

PBMC移入NOGマウス背景データ

• PBMC移入NOGマウスの作製方法

PBMC移入NOGマウスの動画

NOGマウスの樹立、特徴、主な研究用途をご紹介します。

動画を見る

NOGマウスの文献集

文献集へ

文献集

2024年度

Kidney Immune Cell Characterization of Humanized Mouse Models (NOG mouse, NOG-EXL mouse, PBMC)
Kidney360. 2024 Jan 1;5(1):96-109. doi: 10.34067/KID.0000000000000300. Epub 2023 Dec 1.
Noel S, Kurzhagen JT, Lee SA, Sadasivam M, Hamad ARA, Pierorazio PM, Rabb H.

Bispecific immune cell engager enhances the anticancer activity of CD16+ NK cells and macrophages in vitro, and eliminates cancer metastasis in NK humanized NOG mice(antibodies, bispecific; cytotoxicity; immunologic; NOG mouse; NOG-IL15 mouse; NOG-IL2 mouse)
J Immunother Cancer. 2024 Mar 15;12(3):e008295. doi: 10.1136/jitc-2023-008295.
Shahryar Khoshtinat Nikkhoi, Ge Yang, Hajar Owji, Mayara Grizotte-Lake, Rick I Cohen, Lazaro Gil Gonzalez, Mohammad Massumi, Arash Hatefi

Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice (CD34+ cells; Hematopoiesis; Hematopoietic stem cells; Humanized mice; NOG mouse, NOG-EXL mouse)
Stem Cell Res Ther. 2024 Jun 21;15(1):182. doi: 10.1186/s13287-024-03799-w.
Ito R, Ohno Y, Mu Y, Ka Y, Ito S, Emi-Sugie M, Mochizuki M, Kawai K, Goto M, Ogura T, Takahashi R, Niwa A, Nakahata T, Ito M.

Fetal liver CD34+ contain human immune and endothelial progenitors and mediate solid tumor rejection in NOG mice(Allogeneic tumor rejection; Cord blood CD34; Endothelial disfunction; Fetal liver CD34; Graft-versus-tumor; HSPC; Humanized mice; LSEC; Sinusoidal dilatation; NOG mouse)
Stem Cell Res Ther. 2024 Jun 9;15(1):164. doi: 10.1186/s13287-024-03756-7.
Celhar T, Li X, Zhao Y, Tay HC, Lee A, Liew HH, Shepherdson EK, Rajarethinam R, Fan Y, Mak A, Chan JKY, Singhal A, Takahashi T.

A splicing isoform of PD-1 promotes tumor progression as a potential immune checkpoint(PD1; Immune checkpoint ecepter; NOG mouse)
Nat Commun. 2024 Oct 23;15(1):9114. doi: 10.1038/s41467-024-53561-2.
Wang X, Liu T, Li Y, Ding A, Zhang C, Gu Y, Zhao X, Cheng S, Cheng T, Wu S, Duan L, Zhang J, Yin R, Shang M, Gao S.

A Novel Immunodeficient Hyperglycemic Mouse Carrying the Ins1 Akita Mutation for Xenogeneic Islet Cell Transplantation (NOG mpouse; Ins1C96Y/C96Y NOG mouse)
Transplantation. 2024 Aug 6. doi: 10.1097/TP.0000000000005152. Online ahead of print.
Nakano K, Goto M, Fukuda S, Yanobu-Takanashi R, Yabe SG, Shimizu Y, Sakuma T, Yamamoto T, Shimoda M, Okochi H, Takahashi R, Okamura T.

Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate: immune mechanisms of recurrent early pregnancy loss (CD56+CD39+ dNK subset; M-CSF; NOG mice; adoptive transfer; placental trophoblast cell fate; recurrent pregnancy loss.)
Natl Sci Rev. 2024 Apr 11;11(6):nwae142. doi: 10.1093/nsr/nwae142. eCollection 2024 Jun.
Jia W, Ma L, Yu X, Wang F, Yang Q, Wang X, Fan M, Gu Y, Meng R, Wang J, Li Y, Li R, Shao X, Wang YL.

Study on the Extrapolability of Current Tumorgenicity Test With Mice by Comparing the Syngeneic or Allogeneic Mouse Transplantation Model(NOG mouse; allogeneic transplantation; extrapolability; induced pluripotent stem cell; syngeneic transplantation; tumorigenicity test.)
Comparative Study Stem Cells Transl Med. 2024 Jun 14;13(6):572-581.
Tamura T, Tahara T, Inoue M, Nanjo R, Onoe H, Yamamoto T, Kawamata S.

Lansoprazole inhibits the development of sessile serrated lesions by inducing G1 arrest via Skp2/p27 signaling pathway (Chemoprevention; Connectivity map; Lansoprazole; Organoid; Sessile serrated lesion, NOG mice)
J Gastroenterol. 2024 Jan;59(1):11-23. doi: 10.1007/s00535-023-02052-0. Epub 2023 Nov 22.
Kawaguchi T, Okamoto K, Fujimoto S, Bando M, Wada H, Miyamoto H, Sato Y, Muguruma N, Horimoto K, Takayama T.

Engraftment of human mesenchymal stem cells in a severely immunodeficient mouse(Mesenchymal stem cells; Mesenchymal stromal cells; NOG mouse; Regenerative medicine; Transplantation; Xenograft model)
Inflamm Regen. 2024 Sep 26;44(1):40. doi: 10.1186/s41232-024-00353-2.
Kato Y, Ohno Y, Ito R, Taketani T, Matsuzaki Y, Miyagi S.

A Novel Immunodeficient Hyperglycemic Mouse Carrying the Ins1 Akita Mutation for Xenogeneic Islet Cell Transplantation(NOG mpouse; Ins1C96Y/C96Y NOG mouse)
Transplantation. 2024 Aug 6. doi: 10.1097/TP.0000000000005152. Online ahead of print.
Nakano K, Goto M, Fukuda S, Yanobu-Takanashi R, Yabe SG, Shimizu Y, Sakuma T, Yamamoto T, Shimoda M, Okochi H, Takahashi R, Okamura T.

Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate: immune mechanisms of recurrent early pregnancy loss(CD56+CD39+ dNK subset; M-CSF; NOG mice; adoptive transfer; placental trophoblast cell fate; recurrent pregnancy loss)
Natl Sci Rev. 2024 Apr 11;11(6):nwae142. doi: 10.1093/nsr/nwae142. eCollection 2024 Jun.
Jia W, Ma L, Yu X, Wang F, Yang Q, Wang X, Fan M, Gu Y, Meng R, Wang J, Li Y, Li R, Shao X, Wang YL.

Study on the Extrapolability of Current Tumorgenicity Test With Mice by Comparing the Syngeneic or Allogeneic Mouse Transplantation Model (NOG mouse; allogeneic transplantation; extrapolability; induced pluripotent stem cell; syngeneic transplantation; tumorigenicity test.)
Comparative Study Stem Cells Transl Med. 2024 Jun 14;13(6):572-581. doi: 10.1093/stcltm/szae019.
Tamura T, Tahara T, Inoue M, Nanjo R, Onoe H, Yamamoto T, Kawamata S.

Lansoprazole inhibits the development of sessile serrated lesions by inducing G1 arrest via Skp2/p27 signaling pathway(Chemoprevention; Connectivity map; Lansoprazole; Organoid; Sessile serrated lesion, NOG mice)
J Gastroenterol. 2024 Jan;59(1):11-23. doi: 10.1007/s00535-023-02052-0. Epub 2023 Nov 22.
Kawaguchi T, Okamoto K, Fujimoto S, Bando M, Wada H, Miyamoto H, Sato Y, Muguruma N, Horimoto K, Takayama T.

Antitumor Effects of Intravenous Natural Killer Cell Infusion in an Orthotopic Glioblastoma Xenograft Murine Model and Gene Expression Profile Analysis (NK cell; glioblastoma; murine orthotopic xenograft model; NOG mouse)
Int J Mol Sci. 2024 Feb 19;25(4):2435. doi: 10.3390/ijms25042435.
Morimoto T, Nakazawa T, Matsuda R, Maeoka R, Nishimura F, Nakamura M, Yamada S, Park YS, Tsujimura T, Nakagawa I.

Epstein-barr virus infections induce aberrant osteoclastogenesis in immune system-humanized NOD/Shi-scid/IL-2RγCnull mice(EBV; huNOG; RNKL; MMP9; NOG mouse)
Biochem Biophys Res Commun. 2024 Jun 30:715:149984. doi: 10.1016/j.bbrc.2024.149984. Epub 2024 Apr 23.
Nagatsuka Y, Iwata M, Nagasawa Y, Tsuzuki H, Kitamura N, Komatsu A, Kawana K, Ito R, Fujiwara S, Nakamura H, Takei M.

Mitochondrial dynamics as a potential therapeutic target in acute myeloid leukemia(AML; DNM1L; MFF; Mdivi-1; Mitochondrial dynamics; NOG mouse)
Int J Hematol. 2024 Nov;120(5):601-612. doi: 10.1007/s12185-024-03843-8. Epub 2024 Sep 16.
Kinoshita M, Saito Y, Otani K, Uehara Y, Nagasawa S, Nakagawa M, Yamada A, Kamimura S, Moritake H.

Resistin Regulates Inflammation and Insulin Resistance in Humans via the Endocannabinoid System(endocannabinoid system (ECS); PBMCs; NOG mice)
Research (Wash D C). 2024 Apr 2:7:0326. doi:10.34133/research.0326. eCollection 2024.
Yang HM, Kim J, Kim BK, Seo HJ, Kim JY, Lee JE, Lee J, You J, Jin S, Kwon YW, Jang HD, Kim HS.

Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts(HCC PDX; HSC; NOG; NOG-EXL (huGM-CSF/huIL-3 NOG) mice)
bioRxiv[Preprint]. 2024 Oct 31:2023.10.05.561117. doi: 10.1101/2023.10.05.561117.
Weinfurtner K, Tischfield D, McClung G, Crainic J, Gordan J, Jiao J, Furth EE, Li W, Tuzneen Supan E, Nadolski GJ, Hunt SJ, Kaplan DE, Gade TPF.

Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease(Fatty Acid; Mitochondrial Oxidative Phosphorylation; GVHD; NOG; NOG-ΔMHC (MHC class I/II-deficient))
Immunohorizons. 2024 Mar 1;8(3):228-241. doi: 10.4049/immunohorizons.2300115.
Nakano H, Sato K, Izawa J, Takayama N, Hayakawa H, Ikeda T, Kawaguchi SI, Mashima K, Umino K, Morita K, Ito R, Ohno N, Tominaga K, Endo H, Kanda Y.

Ligustilide Inhibits the PI3K/AKT Signalling Pathway and Suppresses Cholangiocarcinoma Cell Proliferation, Migration, and Invasion(EMT; Ligustilide; cholangiocarcinoma; malignant tumor.; proliferation; signal pathway; NOG mouse)
Recent Pat Anticancer Drug Discov. 2024 Aug 20. doi: 10.2174/0115748928332384240812060751. Online ahead of print.
Wu Y, Rong L, Zhang S, He Y, Song N, Zuo G, Mei Z.

Oxymatrine inhibits migration and invasion of esophageal squamous cell carcinoma cell lines via the MEK1/ERK/β-catenin pathway(EMT; ESCC; Invasion; MEK1/ERK/β-catenin; Oxymatrine; NOG mouse)
Chem Biol Interact. 2024 Dec 1:404:111270. doi: 10.1016/j.cbi.2024.111270. Epub 2024 Oct 16.
Xu B, Qiu T, Yang R, Qiang J, Yang Y, Zhou M, Li X, Dong J, Lu Y, Dong Z.

Therapeutic Potential of Bipolar Androgen Therapy for Castration-Resistant Prostate Cancer: In Vitro and In Vivo Studies(bipolar androgen therapy; castration resistant; prostate cancer; supraphysiologic; testosterone; NOG mouse)
Biomedicines. 2024 Jan 15;12(1):181. doi: 10.3390/biomedicines12010181.
Yu J, Lim JE, Song W.

High efficacy of huCD20-targeted AcTaferon in humanized patient derived xenograft models of aggressive B cell lymphoma(Hu-PDX; B cell lymphoma; huCD20+ aggressive B non-Hodgkin lymphomas (B-NHLs); NOG mouse)
Exp Hematol Oncol. 2024 Jun 3;13(1):59. doi: 10.1186/s40164-024-00524-4.
Daneels W, Van Parys A, Huyghe L, Rogge E, De Rouck S, Christiaen R, Zabeau L, Taveirne S, Van Dorpe J, Kley N, Cauwels A, Depla E, Tavernier J, Offner F.

Membrane palmitoylated protein MPP1 inhibits immune escape by regulating the USP12/ CCL5 axis in urothelial carcinoma(CCL5; Chemotaxis; Immune escape; MPP1; Urothelial carcinoma; Hu-NOG, NOG mouse)
Int Immunopharmacol. 2024 Dec 18:146:113802. doi: 10.1016/j.intimp.2024.113802.
Wu Q, Lv J, Li X.

Identification of gene mutations associated with the phenotype of short-limb mice emerging from a foundation colony of severely immunodeficient mice(NOG mice; causative gene analysis; growth differentiation factor 5; short-limb mice)
Exp Anim. 2024 Sep 11. doi: 10.1538/expanim.24-0045. Online ahead of print.
Kaneko Y, Tomiyama K, Yasuda M, Komaki Y, Ogura T, Takahashi R, Yamamoto M.

Engineering a controllable and reversible switch for CAR-based cellular immunotherapies via a genetic code expansion system(OCK; CAR-based cellular immunotherapies; Controllable and reversible; Genetic code expansion system; Switch; NOG mouse)
J Hematol Oncol. 2024 Dec 18;17(1):122. doi: 10.1186/s13045-024-01648-0.
Liu Y, An L, Wang X, Dai Y, Zhang C, Wen Q, Zhang X.

Pharmacokinetic and Environmental Risk Assessment of Prime-2-CoV, a Non-Replicating Orf Virus-Based Vaccine against SARS-CoV-2(Orf virus; biodistribution; environmental risk assessment; poxvirus; shedding; vaccine; viral vector; NOG mice)
Vaccines (Basel). 2024 May 2;12(5):492. doi: 10.3390/vaccines12050492.
Metz C, Haug V, Müller M, Amann R.

Low-dose treatment with Epirubicin, a novel histone deacetylase 1 inhibitor, exerts anti-leukemic effects by inducing ferroptosis(Epirubicin; Ferroptosis; HDAC1; Leukemia; NOG mice)
Eur J Pharmacol. 2024 Dec 15:985:177058. doi: 10.1016/j.ejphar.2024.177058. Epub 2024 Oct 14.
Yang G, Yang S, Li J, Jiang P, Tian X, Wang X, Wei J, Zhang X, Liu J.

Potential treatment approaches for malignant peritoneal mesothelioma: in vivo and in vitro experimental study of natural killer cell immunotherapy(Malignant peritoneal mesothelioma; cell immunotherapy; immunotherapy; intraperitoneal injection; natural killer cells; NOG mice)
Cancer Biol Med. 2024 Nov 1:j.issn.2095-3941.2024.0218. doi: 10.20892/j.issn.2095-3941.2024.0218.
Wu H, Wang Y, Lin Y, Ma R, Du X, Su Y, Yang R, Yang Z, Liang X, Zhang Y, Liang X, Ji Z, Lai C, Huang Y, Li Y.

A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency(E7820; PDX; RNA splicing; NOG mouse)
NPJ Precis Oncol. 2024 May 24;8(1):117. doi: 10.1038/s41698-024-00610-0.
Shinji Kohsaka, Shigehiro Yagishita, Yukina Shirai, Yusuke Matsuno, Toshihide Ueno, Shinya Kojima, Hiroshi Ikeuchi, Masachika Ikegami, Rina Kitada,Ken-ichiYoshioka, Kohta Toshimitsu, Kimiyo Tabata, Akira Yokoi, Toshihiko Doi, NoboruYamamoto, Takashi Owa, Akinobu Hamada &Hiroyuki Mano

Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1α and tumor progression of clear cell ovarian cancer(HIF-1α; PDGF; cancer-associated fibroblasts; chemoresistant niche; ovarian clear cell carcinoma; NOG mice)
Cell Rep Med. 2024 May 21;5(5):101532. doi: 10.1016/j.xcrm.2024.101532. Epub 2024 Apr 25.
Yutaro Mori, Yoshie Okimoto, Hiroaki Sakai, Yusuke Kanda, Hirokazu Ohata, Daisuke Shiokawa, Mikiko Suzuki, Hiroshi Yoshida, Haruka Ueda, Tomoyuki Sekizuka, Ryo Tamura, Kaoru Yamawaki, Tatsuya Ishiguro, Raul Nicolas Mateos, Yuichi Shiraishi, Yasushi Yatabe, Akinobu Hamada, Kosuke Yoshihara, Takayuki Enomoto, Koji Okamoto

2023年度

HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.(Bladder cancer; Glycolysis; IGF2BP1; Immunesensitivity ; PKM2; circFAM13B. Humanized NOG
J Exp Clin Cancer Res. 2023 Feb 6;42(1):41. doi: 10.1186/s13046 023 02614 3.
Lv J, Li K, Yu H, Han J, Zhuang J, Yu R, Cheng Y, Song Q, Bai K, Cao Q, Yang H, Yang X, Lu Q.

Spontaneous early-onset neurodegeneration in the brainstem and spinal cord of NSG, NOG, and NXG mice.(CD34; NOG; NSG; NXG; gliosis; neurodegeneration; spontaneous lesion; vacuolation.)
Vet Pathol . 2023 May;60(3):374-383. doi: 10.1177/03009858231151403. Epub 2023 Feb 2.
Finesso G, Willis E, Tarrant JC, Lanza M, Sprengers J, Verrelle J, Banerjee E, Hermans E, Assenmacher CA, Radaelli E.

A repeat-dose toxicity study of human umbilical cord mesenchymal stem cells in NOG mice by intravenous injection.(Human umbilical cord mesenchymal stem cells; NOG mice; colonization; distribution; repeat dose toxicity.)
Expert Opin Drug Metab Toxicol. 2023 Jul Dec;19(11):857 866. doi: 10.1080/17425255.2023.2279243. Epub 2023 Nov 17.
Shao J, Xia L, Ye Z, Yang Q, Zhang C, Shi Y, Zhang L, Gu L, Xu C, Chen Y, Chen Y, Pan X, Wu F, Pan R, Liang J, Zhang L.

Clinicopathological characteristics associated with the engraftment of patient lymphoma cells in NOG mice.(Diffuse large B-cell lymphoma; NOG mouse; Patient derived lymphoma cells.)
Int J Hematol . 2023 Aug;118(2):221 230. doi: 10.1007/s12185 023 03604 z. Epub 2023 May 2.
Sahashi S, Shimada K, Takagi Y, Aoki T, Kunou S, Sakamoto A, Murase A, Furukawa K, Kagaya Y, Yamaga Y, Takai M, Tokuyama K, Shimada S, Nakamura S, Kiyoi H.

Effect of Systemic Administration of CD4-T cells and Local Administration of T cell Stimulants on T cell Activity in Psoriatic Skin Xenografts on NOG Mice.(CD4+ T Lymphocytes, Heterograft, Psoriasis, NOG mouse)
Comp Med. 2023 Aug 27;73(4):285-293. doi: 10.30802/AALAS CM 23 000006.
Christensen PK, Hansen AK, Skov S, Larsen J, Høyer-Hansen MH, Koch J.

Baicalein Inhibits the Growth of Transplanted Esophageal Cancer in Mice and the Effect on the Expression of PAK4.(PAK4; baicalein; esophageal cancer; NOG mice; transplanted tumor of esophageal cancer)
Bull Exp Biol Med. 2023 Feb;174(4):478-481. doi: 10.1007/s10517 023 05733 1. Epub 2023 Mar 10.
Liu Y, Sun X, Liu J, Liu W, Jin J, Liu Y.

Establishment of a human microbiome and immune system reconstituted dual humanized mouse model.(CD34+ cells; NOG mice; fecal microbiota transplantation; germ free; humanized mice)
Exp Anim. 2023 Aug 7;72(3):402-412. doi: 10.1538/expanim.23 0025. Epub 2023 Apr 4.
Ka Y, Ito R, Nozu R, Tomiyama K, Ueno M, Ogura T, Takahashi

Lysine N-methyltransferase SETD7 promotes bladder cancer progression and immune escape via STAT3/PD L1 cascade.(SETD7; bladder cancer; immune escape; migration; proliferation; Humanized NOG mice)
Int J Biol Sci.2023 Jul 16;19(12):3744 3761. doi: 10.7150/ijbs.87182. eCollection 2023.
Lv J, Wu Q, Li K, Bai K, Yu H, Zhuang J, Sun H, Yang H, Yang X, Lu Q.

Murine models to study human NK cells in human solid tumors.(human in mouse model; humanized NOG mice; natural killer cells; solid tumor; tumor immunity)
Front Immunol. 2023 Jun 14:14:1209237. doi: 10.3389/fimmu.2023.1209237. eCollection 2023.
Parodi M, Astigiano S, Carrega P, Pietra G, Vitale C, Damele L, Grottoli M, Guevara Lopez ML, Ferracini R, Bertolini G, Roato I, Vitale M, Orecchia P.

Clinically relevant humanized mouse models of metastatic prostate cancer to evaluate cancer therapies.(humanized mice, NOG, NOG-EXL, Hot Model, Cold Model, metastatic prostate cancer, cancer therapy)
bioRxiv. 2023 Oct 17:2023.10.13.562280. doi: 10.1101/2023.10.13.562280.
Kostlan RJ, Phoenix JT, Budreika A, Ferrari MG, Khurana N, Cho JE, Juckette K, McCollum BL, Moskal R, Mannan R, Qiao Y, Griend DJV, Chinnaiyan AM, Kregel S.

Characterization of anti-CD79b/CD3 bispecific antibody, a potential therapy for B cell malignancies.(Bispecific; CD79b; Immunotherapy; Non Hodgkin lymphoma; T cell engager; PBMC engrafted NOG mice)
Cancer Immunol Immunother . 2023 Feb;72(2):493 507. doi: 10.1007/s00262 022 03267 5. Epub 2022 Aug 13.
Wang J, Li C, He K, Kuang Z, Lu J, Yao Y, He F, Li N, Li L, Fu F, Wu Z, Zhou S, Kang D, Qiu X, Wu M, Liu Y, Cao X, Xu M, Chen B, Wu W, Guo F.

Methods for preparing tissue microarray slides using xenografts with different levels of HER2 expression to standardize HER2 detection.(HER2 test; gastric cancer; immunohistochemistry; tissue microarray; xenograft; NOG
Pathol Int. 2023 Jan;73(1):39-44. doi: 10.1111/pin.13288. Epub 2022 Nov 18.
Yorozu K, Kurasawa M, Iino Y, Nakamura Y, Hashizume K, Harada N, Ochiai A.

Efficacy of adoptively transferred allogeneic CIK cells on colorectal cancer: Augmentative antitumoral effects of GvHD.(Adoptive transfer; Colorectal neoplasms; Cytokine induced killer cells; Graft vs host disease; Treatment outcome; Xenograft model antitumor assays.)
Int Immunopharmacol 2023 Jan:114:109446. doi: 10.1016/j.intimp.2022.109446. Epub 2022 Dec 1.
Muhammadnejad S, Monzavi SM, Torabi Rahvar M, Sotoudeh M, Muhammadnejad A, Tavakoli Shiraji S, Ranjbar A, Aghayan SS, Khorsand AA, Moradzadeh K, Janzamin E, Ahmadbeigi N.

Lansoprazole inhibits the development of sessile serrated lesions by inducing G1 arrest via Skp2/p27 signaling pathway.(Chemoprevention; Connectivity map; Lansoprazole; Organoid; Sessile serrated lesion; NOG mice)
J Gastroenterol. 2023 Nov 22. doi: 10.1007/s00535-023-02052-0. Online ahead of print.
Kawaguchi T, Okamoto K, Fujimoto S, Bando M, Wada H, Miyamoto H, Sato Y, Muguruma N, Horimoto K, Takayama T. Human serum

Human serum albumin promotes self-renewal and expansion of umbilical cord blood CD34＋ hematopoietic stem/progenitor cells.(Hematopoietic stem/progenitor cells (HSPCs); expansion in vitro; human serum albumin (HSA); transplantation; NOG)
Ann Transl Med . 2023 Jan 31;11(2):62. doi:10.21037/atm 22 6383. Epub 2023 Jan 13.
Hua J, Jiao T, Qiao Y, Zhang S, Xiao T, Zhang Y, Yan J.

A Novel Approach for Determining the Critical Quality Attributes of Mesenchymal Stem Cells by Specifying Cell Population With Replication Potential.(Redox system; critical process parameter; critical quality attribute; mesenchymal stem cells; mitochondrial function; NOG mice)
Stem Cells Transl Med. 2023 Mar 17;12(3):169 182. doi: 10.1093/ stcltm /szad005
Yamamoto T, Arita M, Tamura T, Saito M, Katayama H, Kuroda H, Suzuki T, Kawamata S.

Annihilation of Non-small Cell Lung Cancer by NKG2D CAR T Cells Produced from T Cells from Peripheral Blood of Healthy Donors. (CAR T cells; NKG2D NKG2DL signaling; antitumor effect; non small cell lung cancer; solid tumor; NOG mice))
J Interferon Cytokine Res. 2023 Oct;43(10):445 454. doi: 10.1089/jir.2023.0043.
Jiang J, Liu Y, Zeng Y, Fang B, Chen Y.

Pharmacology, pharmacokinetics, and toxicity characterization of a novel anti-CD73 therapeutic antibody IBI325 for cancer immunotherapy (CD73 antagonist; Cancer immunotherapy; IBI325; Therapeutic antibody; hPBMC reconstituted NOG mouse)
Int J Biol Macromol . 2023 Feb 28:229:158 167. doi: 10.1016/j.ijbiomac.2022.12.258. Epub 2022 Dec 29.
Zhou Y, Shen H, Wu M, Wang J, Wu Z, Fu F, Liu Y, Lu J, Yao Y, Luo N, Zhou S, Tan KS, Chen B, Wang D.

PEGylated Polymeric Nanoparticles Loaded with 2-Methoxyestradiol for the Treatment of Uterine Leiomyoma in a Patient Derived Xenograft Mouse Model.(Bioavailability; Drug delivery system; Estrogen; Fibroid; Nanoparticles; Precision medicine; NOG mice)
J Pharm Sci. 2023 Sep;112(9):2552-2560. doi: 10.1016/j.xphs.2023.07.018. Epub 2023 Jul 21.
Enazy SA, Kirschen GW, Vincent K, Yang J, Saada J, Shah M, Oberhauser AF, Bujalowski PJ, Motamedi M, Salama SA, Kilic G, Rytting E, Borahay MA.

Next generation oncolytic viruses expressing PADI1 and TIMP2 exhibit anti-tumor activity against melanoma in nude and humanized mouse models.(PADI1; TIMP2; animal studies; arginine deiminase; arginine deprivation; cancer models; humanized NOG tumor model; immunotherapy; melanoma; oncolytic adenovirus.)
Mol Ther Oncolytics. 2023 Jan 13:28:158 170. doi: 10.1016/j.omto.2023.01.002. eCollection 2023 Mar 16.
Kuryk L, Møller AW.

DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming.(AML; DNMT3A mutation; Metabolic reprogramming; NAM-NAD metabolism; NAMPT; NOG mice)
J Transl Med. 2023 Jul 18;21(1):481. doi: 10.1186/s12967 023 04323 z.
Yang X, Wang X, Yang Y, Li Z, Chen Y, Shang S, Wang Y.

Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukemia protein 1 H3K4me3 mediated immune escape in esophageal squamous cell carcinoma.(esophageal squamous cell carcinoma; immune escape; immunotherapy; lncRNA; mixed lineage leukemia protein-1 (MLL1); huPBMC NOG mice)
Clin Transl Med. 2023 Sep;13(9):e1410. doi: 10.1002/ctm2.1410.
Liu J, Zhou WY, Luo XJ, Chen YX, Wong CW, Liu ZX, Bo Zheng J, Yu Mo H, Chen JQ, Li JJ, Zhong M, Xu YH, Zhang QH, Pu HY, Wu QN, Jin Y, Wang ZX, Xu RH, Luo HY.

Disintegration of the NuRD Complex in Primary Human Muscle Stem Cells in Critical Illness Myopathy (critical illness; epigenetic; histone 1; muscle stem cell; NOG mice)
Int J Mol Sci. 2023 Feb 1;24(3):2772. doi: 10.3390/ijms24032772.
Schneider J, Sundaravinayagam D, Blume A, Marg A, Grunwald S, Metzler E, Escobar H, Müthel S, Wang H, Wollersheim T, Weber-Carstens S, Akalin A, Di Virgilio M, Tursun B, Spuler S.

2022年度

NOD/SCID/gamma(c)(null) mouse:an excellent recipient mouse model for engraftment of human cells. (NOG, original paper)
Blood. 2002 Nov 1;100(9):3175 82. doi: 10.1182/blood 2001 12 0207.
Mamoru Ito, Hidefumi Hiramatsu, Kimio Kobayashi, Kazutomo Suzue, Mariko Kawahata, Kyoji Hioki, Yoshito Ueyama, Yoshio Koyanagi, Kazuo Sugamura, Kohichiro Tsuji, Toshio Heike, Tatsutoshi Nakahata

High Incidence of Lymph-node Metastasis in a Pancreatic-cancer Patient-derived Orthotopic Xenograft (PDOX) NOG-Mouse Model. (NOG, PODX-Pancreatic cancer)
Anticancer Res. 2022 Feb;42(2):739-743. doi:10.21873/anticanres.15532.
Norihiko Sugisawa , Kentaro Miyake, Takashi Higuchi, Hiromichi Oshiro, Jun Ho Park, Kei Kawaguchi, Michael Bouvet, Michiaki Unno, Robert M Hoffman

Discovery of potent immune modulating molecule taccaoside A against cancers from structures active relationships of natural steroidal saponins.(NOG, immune modulating molecule)
Phytomedicine. 2022 Sep;104:154335. doi: 10.1016/j.phymed.2022.154335. Epub 2022 Jul 11.
Zhi Dai, Pei-Feng Zhu, Hui Liu, Xuan-Chen Li, Yan-Yan Zhu, Yang-Yang Liu, Xiao-Long Shi, Wei-Di Chen, Ya-Ping Liu, Yun-Li Zhao, Li-Xing Zhao, Hai-Yang Liu, Xiao-Dong Luo

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity. (NOG, CAR-T)
Blood. 2022 Jan 27;139(4):523-537. doi: 10.1182/blood.2021011597.
Christopher Ronald Funk, Shuhua Wang, Kevin Z Chen, Alexandra Waller, Aditi Sharma, Claudia L Edgar, Vikas A Gupta, Shanmuganathan Chandrakasan, Jaquelyn T Zoine, Andrew Fedanov, Sunil S Raikar, Jean L Koff, Christopher R Flowers, Silvia Coma, Jonathan A Pachter, Sruthi Ravindranathan, H Trent Spencer, Mala Shanmugam, Edmund K Waller

Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma (NOG, IL22 cutaneous T-cell lymphoma).
Cancer Sci. 2022 Apr;113(4):1208-1219. doi: 10.1111/cas.15296. Epub 2022 Feb 20.
Matsuda Y, Ikeda S, Abe F, Takahashi Y, Kitadate A, Takahashi N, Wakui H, Tagawa H.

Establishment of Patient-derived Preclinical Models for Invasive Papillary Cholangiocarcinoma. (NOG, Invasive Papillary Cholangiocarcinoma PDX)
Anticancer Res. 2022 Jan;42(1):599-608. doi: 10.21873/anticanres.15517.
Mwesige B, Lee MR, Lee YS, Han NY, Im JE, Kim JK, Choi SI, Hong EK, Jeon AR, Park SJ, Woo SM, Kim YH.

Inhibition of MACC1-Induced Metastasis in Esophageal and Gastric Adenocarcinomas. (NOG, Metastasis, Esophageal, Gastric Adenorcinoma).
Cancers (Basel). 2022 Mar 31;14(7):1773. doi: 10.3390/cancers14071773.
Treese C, Werchan J, von Winterfeld M, Berg E, Hummel M, Timm L, Rau B, Daberkow O, Walther W, Daum S, Kobelt D, Stein U.

Glucose metabolism inhibitor PFK-015 combined with immune checkpoint inhibitor is an effective treatment regimen in cancer. (PBMC humanized mice, NOG, Cancer Immunotherapy)
Oncoimmunology. 2022 May 25;11(1):2079182. doi: 10.1080/2162402X.2022.2079182. eCollection 2022.
Zheng JB, Wong CW, Liu J, Luo XJ, Zhou WY, Chen YX, Luo HY, Zeng ZL, Ren C, Xie XM, Wang DS.

Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML. (AML-PDX, NOG, NOG-EXL)
In Vivo. 2022 Jul-Aug;36(4):1615-1627. doi: 10.21873/invivo.12872.
Daniel H Albert, Neal C Goodwin, Angela M Davies, Jenny Rowe, Gerold Feuer, Michael Boyiadzis, Kathleen A Dorritie, Maria Mancini, Regina Gandour-Edwards, Brian A Jonas, Gautam Borthakur, Ibrahim Aldoss, David A Rizzieri, Olatoyosi Odenike, Thomas Prebet, Sanjana Singh, Relja Popovic, Y U Shen, Keith F McDaniel, Warren M Kati, Dimple A Modi, Monica Motwani, Johannes E Wolff, David J Frost

Spontaneous xenogeneic GvHD in Wilms' tumor Patient-Derived xenograft models and potential solutions. (NOG, Wilmsʼ tumor, PDX)
Animal Model Exp Med. 2022 Dec;5(4):389-396. doi: 10.1002/ame2.12254. Epub 2022 Jun 20.
Seyed Mostafa Monzavi , Ahad Muhammadnejad, Maryam Behfar, Amir Arsalan Khorsand, Samad Muhammadnejad, Abdol-Mohammad Kajbafzadeh

The first Japanese biobank of patient-derived pediatric acute lymphoblastic leukemia xenograft models. (NOG, ALL-PDX)
Cancer Sci. 2022 Jul 25. doi: 10.1111/cas.15506.
Kuniaki Tanaka, Itaru Kato, Yuu Dobashi, Jun-Ichi Imai, Takashi Mikami, Hirohito Kubota, Hiroo Ueno, Mamoru Ito, Seishi Ogawa, Tatsutoshi Nakahata, Junko Takita, Hidemi Toyoda, Chitose Ogawa, Souichi Adachi, Shinya Watanabe, Hiroaki Goto

Flow Cytometric Measurement of Reactive Oxygen Species to Assess the Effects of Preconditioning Total Body Irradiation on NOG Mice. (Preconditioning; Irradiation、NOG)
Asian Pac J Cancer Prev. 2022 Feb 1;23(2):383-388. doi: 10.31557/APJCP.2022.23.2.383.
Kavianpour M, Moradzadeh K, Muhammadnejad S, Jabbarpour Z, Khorsand AA, Aghayan S, Vasei M, Verdi J.

Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice. (humanized mice, NOG, diabetes, human mesenchymal stromal/stem cells)
Stem Cell Res Ther. 2022 Jul 26;13(1):350. doi: 10.1186/s13287-022-03048-y.
Ghoneim MA, Gabr MM, Refaie AF, El-Halawani SM, Al-Issawi MM, Elbassiouny BL, Kader MAAE, Ismail AM, Zidan MF, Karras MS, Magar RW, Khater SM, Ashamallah SA, Zakaria MM, Kloc M.

Characterization of anti-CD79b/CD3 bispecific antibody, a potential therapy for B cell malignancies. (humanized mice, NOG, PBMC, B cell malignancies)
Cancer Immunol Immunother. 2022 Aug 13. doi: 10.1007/s00262-022-03267-5.
Wang J, Li C, He K, Kuang Z, Lu J, Yao Y, He F, Li N, Li L, Fu F, Wu Z, Zhou S, Kang D, Qiu X, Wu M, Liu Y, Cao X, Xu M, Chen B, Wu W, Guo F.

CD169 (Siglec-1) as a Robust Human Cell Biomarker of Toll-Like Receptor 9 Agonist Immunotherapy (humanized mice, NOG, Immunotherapy, HIV-1)
Front Cell Infect Microbiol. 2022 Jul 5;12:919097. doi: 10.3389/fcimb.2022.919097. eCollection 2022.
Lende SSF, Pahus MH, Monrad I, Olesen R, Mahr AR, Vibholm LK, Østergaard L, Søgaard OS, Andersen AHF, Denton PW, Tolstrup M.

2021年度

Imaging Tumor-Infiltrating Lymphocytes in Brain Tumors with [64Cu]Cu-NOTA-anti-CD8 PET. (Brain tumor, PBMC, humanized mice, NOG)
Clin Cancer Res. 2021 Apr 1;27(7):1958-1966. doi: 10.1158/1078-0432.CCR-20-3243. Epub 2021 Jan 25.
Veronica L Nagle, Kelly E Henry, Charli Ann J Hertz, Maya S Graham, Carl Campos, Luis F Parada, Neeta Pandit-Taskar, Andrea Schietinger, Ingo K Mellinghoff, Jason S Lewis

Adaptive NK Cell Therapy Modulated by Anti-PD-1 Antibody in Gastric Cancer Model. (Cancer Immune therapy, Gastric cancer, NOG)
Front Pharmacol. 2021 Sep 13;12:733075. doi: 10.3389/fphar.2021.733075. eCollection 2021.
Shahrokh Abdolahi, Zeinab Ghazvinian, Samad Muhammadnejad, Mohammad Ahmadvand, Hamid Asadzadeh Aghdaei, Somayeh Ebrahimi-Barough, Jafar Ai, Mohammad Reza Zali, Javad Verdi, Kaveh Baghaei

Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.(chemotherapy, neuroblastoma, NOG)
Int J Cancer. 2021 Mar 1;148(5):1219-1232. doi: 10.1002/ijc.33423. Epub 2020 Dec 17.
Birte Arlt, Christin Zasada, Katharina Baum, Jasmin Wuenschel, Guido Mastrobuoni, Marco Lodrini, Kathy Astrahantseff, Annika Winkler, Johannes H Schulte, Sabine Finkler, Martin Forbes, Patrick Hundsdoerfer, Dennis Guergen, Jens Hoffmann, Jana Wolf, Angelika Eggert, Stefan Kempa, Hedwig E Deubzer

Characterization of a xenograft model for anti-CD19 CAR T cell studies. (CAR-T, Lymphoma, NOG)
Clin Transl Oncol. 2021 Oct;23(10):2181-2190. doi: 10.1007/s12094-021-02626-5. Epub 2021 May 3.
N Ahmadbeigi, S Alatab, M Vasei, A Ranjbar , S Aghayan, A Khorsand, K Moradzadeh , Z Darvishyan, M Jamali, S Muhammadnejad

Ex Vivo Expanded and Activated Natural Killer Cells Prolong the Overall Survival of Mice with Glioblastoma-like Cell-Derived Tumors. (hNK, Glioblastoma, NOG).
Int J Mol Sci. 2021 Sep 15;22(18):9975. doi: 10.3390/ijms22189975.
Shida Y, Nakazawa T, Matsuda R, Morimoto T, Nishimura F, Nakamura M, Maeoka R, Yamada S, Nakagawa I, Park YS, Yasukawa M, Tojo T, Tsujimura T, Nakase H.

HER2-antigen-specific humoral immune response in breast cancer lymphocytes transplanted in hu-PBL hIL-4 NOG mice.
Sci Rep. 2021 Jun 17;11(1):12798. doi: 10.1038/s41598-021-92311-y. (NOG-IL4, Cancer Immune therapy)
Yusuke Ohno, Shino Ohshima, Asuka Miyamoto, Fuyuki Kametani, Ryoji Ito, Banri Tsuda, Yukie Kasama, Shunsuke Nakada, Hirofumi Kashiwagi, Toshiro Seki, Atsushi Yasuda, Kiyoshi Ando, Mamoru Ito, Yutaka Tokuda, Yoshie Kametani

Targeting the Endothelin-1 Receptors Curtails Tumor Growth and Angiogenesis in Multiple Myeloma.(Multiple myeloma, NOG)
Front Oncol. 2021 Jan 8;10:600025. doi: 10.3389/fonc.2020.600025. eCollection 2020.
Russignan A, Dal Collo G, Bagnato A, Tamassia N, Bugatti M, Belleri M, Lorenzi L, Borsi E, Bazzoni R, Gottardi M, Terragna C, Vermi W, Giacomini A, Presta M, Cassatella MA, Krampera M, Tecchio C.

MNS1 promotes hepatocarcinogenesis and metastasis via activating PI3K/AKT by translocating β-catenin and predicts poor prognosis. (Hepatocarcinogenesis, metastasis, NOG).
Liver Int. 2021 Jun;41(6):1409-1420. doi: 10.1111/liv.14803. Epub 2021 Feb 16.
Yi Y, Yu MC, Fu PY, Liu G, Zhou PY, Guan RY, Zhou C, Sun BY, Qiu SJ.

Human endometrial perivascular stem cells exhibit a limited potential to regenerate endometrium after xenotransplantation.(endometrial perivascular stem cells, NOG)
Hum Reprod. 2021 Jan 1;36(1):145-159.
Xinxin Zhu, Fei Yu, Guijun Yan, Yali Hu, Haixiang Sun, Lijun Ding

Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease. (humanized mice, NOG, GVHD)
2021 Nov 11;7(11):e08380.
Hiroshi Tsuzuki, Yasuko Nagatsuka, Mitsuhiro Iwata, Noboru Kitamura, Yosuke Nagasawa, Taro Matsumoto, Ryoji Ito, Takeshi Takahashi, Mamoru Ito, Hideki Nakamura, Masami Takei

Utilization of a novel Sendai virus vector in ex vivo gene therapy for hemophilia A. (gene therapy, hemophilia A, NOG)
Int J Hematol. 2021 Apr;113(4):493-499. doi: 10.1007/s12185-020-03059-6. Epub 2021 Jan 1.
Yamaki Y, Fukushima T, Yoshida N, Nishimura K, Fukuda A, Hisatake K, Aso M, Sakasai T, Kijima-Tanaka J, Miwa Y, Nakanishi M, Sumazaki R, Takada H.

CD1d expression in glioblastoma is a promising target for NKT cell-based cancer immunotherapy. (Cancer immunotherapy, iNKT cells, NOG).
Cancer Immunol Immunother. 2021 May;70(5):1239-1254. doi: 10.1007/s00262-020-02742-1. Epub 2020 Oct 31.
Hara A, Koyama-Nasu R, Takami M, Toyoda T, Aoki T, Ihara F, Kobayashi M, Hirono S, Matsutani T, Nakayama T, Iwadate Y, Motohashi S.

Establishment of a Patient-Derived Xenograft Model of Colorectal Cancer in CIEA NOG Mice and Exploring Smartfish Liquid Diet as a Source of Omega-3 Fatty Acids. (NOG, Colorectal Cancer PDX)
Biomedicines. 2021 Mar 10;9(3):282. doi:10.3390/biomedicines9030282.
Helle Samdal, Lene C Olsen, Knut S Grøn, Elin S Røyset, Therese S Høiem, Ingunn Nervik, Pål Sætrom, Arne Wibe, Svanhild A Schønberg, Caroline H H Pettersen

Plasmodium falciparum-infected humanized mice: a viable preclinical tool. (NOG, Plasmodium falciparum)
Immunotherapy. 2021 Nov;13(16):1345-1353. doi: 10.2217/imt-2021-0102. Epub 2021 Aug 23.
Tyagi RK.

Efficient production of immunodeficient non-obese diabetic/Shi-scid IL2r γnull mice via the superovulation technique using inhibin antiserum and gonadotropin. (NOG production)
Lab Anim. 2021 Feb;55(1):13-20. doi: 10.1177/0023677220928091. Epub 2020 Jun 6.

Data on long-term survival of the NOD/Shi-scid IL-2Rγ null (NOG) mouse in two facilities. (survival data, NOG)
J Toxicol Sci. 2021;46(10):453-469. doi: 10.2131/jts.46.453.
Yamashita Y, Sato T, Noishiki K, Kobayashi K, Uchiyama A, Izumi H, Tamura T, Shikamura M, Oinishi Y, Saito M, Kawamata S.

Human Microglia Extensively Reconstitute in Humanized-BLT Mice With Human Interleukin-34 Transgene and Support HIV-1 Brain Infection. (HIV1, NOG, humanized-BLT mice)
Front Immunol. 2021 May 21;12:672415. doi: 10.3389/fimmu.2021.672415. eCollection 2021.
Zhang J, Lohani SC, Cheng Y, Wang T, Guo L, Kim WK, Gorantla S, Li Q.

Establishment of Human Leukocyte Antigen-Mismatched Immune Responses after Transplantation of Human Liver Bud in Humanized Mouse Models. (NOG, humanized mice, HLA mismatched model)
Cells. 2021 Feb 23;10(2):476.
Akihiro Mori, Soichiro Murata, Nao Tashiro, Tomomi Tadokoro, Satoshi Okamoto, Ryo Otsuka, Haruka Wada, Tomoki Murata, Takeshi Takahashi, Ken-Ichiro Seino, Hideki Taniguchi

Liposomal 2-Methoxyestradiol Nanoparticles for Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model. (NOG, Uterine Leiomyoma PDX)
Reprod Sci. 2021 Jan;28(1):271-277. doi: 10.1007/s43032-020-00248-w. Epub 2020 Jul 6.
Mostafa A Borahay, Kathleen L Vincent, Massoud Motamedi, Ibrahim Tekedereli, Salama A Salama, Bulent Ozpolat, Gokhan S Kilic

Elimination of residual undifferentiated induced pluripotent stem cells (iPSCs) using irradiation for safe clinical applications of iPSC-derived cardiomyocytes. (iPSC-derived cardiomyocytes, Tumorigenicity test in NOG)
Biochem Biophys Res Commun. 2021 Oct 15;574:91-96. doi: 10.1016/j.bbrc.2021.08.065. Epub 2021 Aug 24.
Takeda M, Ito E, Minami K, Harada A, Mochizuki-Oda N, Sawa Y, Miyagawa S.

Scaffold-Free Tubular Engineered Heart Tissue From Human Induced Pluripotent Stem Cells Using Bio-3D Printing Technology in vivo. (engineered heart tissue; human-induced pluripotent stem cell, NOG)
Front Cardiovasc Med. 2022 Jan 20;8:806215. doi: 10.3389/fcvm.2021.806215. eCollection 2021.
Kawai Y, Tohyama S, Arai K, Tamura T, Soma Y, Fukuda K, Shimizu H, Nakayama K, Kobayashi E.

Development of a novel anti-B7-H4 antibody enhances anti-tumor immune response of human T cells.(anti-B7-H4 antibody in vivo antitumor efficacy test, NOG)
Biomed Pharmacother. 2021 Sep;141:111913. doi: 10.1016/j.biopha.2021.111913. Epub 2021 Jul 13.
Miao G, Sun X.

2020年度

Establishment of Humanized Mice from Peripheral Blood Mononuclear Cells or Cord Blood CD34+ Hematopoietic Stem Cells for Immune-Oncology Studies Evaluating New Therapeutic Agents. (humanized mice, NOG, Cancer immune-therapy)
Curr Protoc Pharmacol. 2020 Jun;89(1):e77
Verma B, Wesa A.

89 Zr-pembrolizumab biodistribution is influenced by PD-1-mediated uptake in lymphoid organs. (Cancer Immune therapy, humanized mice, NOG)
Elly L van der Veen, Danique Giesen, Linda Pot-de Jong, Annelies Jorritsma-Smit, Elisabeth G E De Vries, Marjolijn N Lub-de Hooge
Elly L van der Veen, Danique Giesen, Linda Pot-de Jong, Annelies Jorritsma-Smit, Elisabeth G E De Vries, Marjolijn N Lub-de Hooge

Supporting clinical decision making in advanced melanoma by preclinical testing in personalized immune-humanized xenograft mouse models. (humanized mice, NOG, NOG-IL2, melanoma PDX, Cancer Immune therapy)
Ann Oncol. 2020 Feb;31(2):266-273. doi: 10.1016/j.annonc.2019.11.002. Epub 2020 Jan 3.
L Ny, L Y Rizzo, V Belgrano, J Karlsson, H Jespersen, L Carstam, R O Bagge, L M Nilsson, J A Nilsson

Co-expressing LRP6 With Anti-CD19 CAR-T Cells for Improved Therapeutic Effect Against B-ALL. (CD19 CAR-T, B-ALL, NOG)
Front Oncol. 2020 Sep 15;10:1346. doi: 10.3389/fonc.2020.01346. eCollection 2020.
Ping He, Zhongqiu Tan, Zhongheng Wei, Cheng-Liang Wan, Shan-Shan Yang

Development and characterization of a novel anti-OX40 antibody for potent immune activation.(anti-OX40 antibody, NOG, Cancer Immune therapy)
Cancer Immunol Immunother. 2020 Jun;69(6):939-950. doi: 10.1007/s00262-020-02501-2. Epub 2020 Feb 20.
Kuang Z, Jing H, Wu Z, Wang J, Li Y, Ni H, Zhang P, Wu W, Wu M, Zhou S, Qiu X, Wu D, Prinz B, Baruah H, Chen B, Yu M, Liu J.

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection (HIV, humanized mice, NOG)
. J Vis Exp. 2020 Jan 31;(155).
Anna H F Andersen, Stine S F Nielsen, Rikke Olesen, Katharina Mack, Frederik Dagnæs-Hansen, Niels Uldbjerg, Lars Østergaard, Ole S Søgaard, Paul W Denton, Martin Tolstrup

Verification of EZH2 as a druggable target in metastatic uveal melanoma. (metastasis melanoma, NOG)
Mol Cancer. 2020 Mar 4;19(1):52. doi:10.1186/s12943-020-01173-x.
Bei Jin, Ping Zhang, Hailin Zou, Huijing Ye, Yun Wang, Jing Zhang, Huasheng Yang, Jingxuan Pan

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma. (human colon organoid, PDX, NOG)
Gastroenterology. 2020 Feb;158(3):638-651.e8. doi: 10.1053/j.gastro.2019.10.009. Epub 2019 Oct 14.
Kawasaki K, Fujii M, Sugimoto S, Ishikawa K, Matano M, Ohta Y, Toshimitsu K, Takahashi S, Hosoe N, Sekine S, Kanai T, Sato T.

The SLAMF3 rs509749 polymorphism correlates with malignant potential in multiple myeloma. (Multiple myeloma, NOG)
Exp Hematol. 2020 Oct;90:72-79. doi: 10.1016/j.exphem.2020.08.006. Epub 2020 Aug 17.
Ishibashi M, Sunakawa-Kii M, Kaito Y, Kinoshita R, Asayama T, Kuribayashi Y, Inokuchi K, Morita R, Tamura H.

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection. (HIV, NOG)
J Vis Exp. 2020 Jan 31;(155). doi: 10.3791/60723.
Andersen AHF, Nielsen SSF, Olesen R, Mack K, Dagnæs-Hansen F, Uldbjerg N, Østergaard L, Søgaard OS, Denton PW, Tolstrup M.

Comparable human reconstitution following Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice. (NOG, comparable human reconstitution following cesium137 vs X-ray)
PLoS One. 2020 Oct 29;15(10):e0241375. doi:10.1371/journal.pone.0241375. eCollection 2020.
Andersen AHF, Nielsen SSF, Olesen R, Harslund JLF, Søgaard OS, Østergaard L, Denton PW, Tolstrup M.

Dasatinib exacerbates splenomegaly of mice inoculated with Epstein-Barr virus-infected lymphoblastoid cell lines. (EBV-LCLs, NOG)
Sci Rep. 2020 Mar 9;10(1):4355. doi: 10.1038/s41598-020-61300-y.
Kotaki R, Kawashima M, Yamamoto Y, Higuchi H, Nagashima E, Kurosaki N, Takamatsu M, Kikuti YY, Imadome KI, Nakamura N, Kotani A.

A long-acting 3TC ProTide nanoformulation suppresses HBV replication in humanized mice.(humanized mice, NOG, HBV replication)
Nanomedicine. 2020 Aug;28:102185. doi: 10.1016/j.nano.2020.102185. Epub 2020 Mar 24.
Wang W, Smith N, Makarov E, Sun Y, Gebhart CL, Ganesan M, Osna NA, Gendelman HE, Edagwa BJ, Poluektova LY.

Antioxidant Small Molecule Compound Chrysin Promotes the Self-Renewal of Hematopoietic Stem Cells.(humanized mice, NOG, Self-Renewal)
Front Pharmacol. 2020 Apr 2;11:399. doi: 10.3389/fphar.2020.00399. eCollection 2020.
Li Y, He M, Zhang W, Yang M, Ding Y, Xu S, Gu J, Li Y, Yin J, Gao Y.

Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms. (Human mesenchymal stem cells, humanized mice, GVHD, NOG)
World J Stem Cells. 2020 Sep 26;12(9):1032-1049. doi: 10.4252/wjsc.v12.i9.1032.
Song Y, Lim JY, Lim T, Im KI, Kim N, Nam YS, Jeon YW, Shin JC, Ko HS, Park IY, Cho SG.

Patient-derived xenograft (PDX) models: characteristics and points to consider for the process of establishment. (PDX, NOG)
J Toxicol Pathol. 2020 Jul;33(3):153-160. doi: 10.1293/tox.2020-0007. Epub 2020 Mar 20.
Etsuko Fujii, Atsuhiko Kato, Masami Suzuki

Nonclinical safety, tolerance and pharmacodynamics evaluation for meplazumab treating chloroquine-resistant Plasmodium falciparum.(ADA, ADCC, Plasmodium falciparum, humanized mice, NOG)
Acta Pharm Sin B. 2020 Sep;10(9):1680-1693. doi: 10.1016/j.apsb.2020.06.011. Epub 2020 Jun 30.
Zhang K, Zhao Y, Zhang Z, Zhang M, Wu X, Bian H, Zhu P, Chen Z.

Establishment of Humanized Mice from Peripheral Blood Mononuclear Cells or Cord Blood CD34+ Hematopoietic Stem Cells for Immune-Oncology Studies Evaluating New Therapeutic Agents. (Immune therapy, PBMC, HSC, humanized mice)
Curr Protoc Pharmacol. 2020 Jun;89(1):e77
Verma B, Wesa A.

Nonclinical safety, tolerance and pharmacodynamics evaluation for meplazumab treating chloroquine-resistant Plasmodium falciparum.(ADA, ADCC, Plasmodium falciparum, humanized mice, NOG)
Acta Pharm Sin B. 2020 Sep;10(9):1680-1693. doi: 10.1016/j.apsb.2020.06.011. Epub 2020 Jun 30.
Zhang K, Zhao Y, Zhang Z, Zhang M, Wu X, Bian H, Zhu P, Chen Z.

TNFSF15 facilitates human umbilical cord blood haematopoietic stem cell expansion by activating Notch signal pathway. (humanized mice, NOG, TNFSF15)
J Cell Mol Med. 2020 Oct;24(19):11146-11157. doi: 10.1111/jcmm.15626. Epub 2020 Sep 10.
Ding Y, Gao S, Shen J, Bai T, Yang M, Xu S, Gao Y, Zhang Z, Li L.

Antioxidant Small Molecule Compound Chrysin Promotes the Self-Renewal of Hematopoietic Stem Cells. (humanized mice, NOG, Self-Renewal)
Front Pharmacol. 2020 Apr 2;11:399. doi: 10.3389/fphar.2020.00399. eCollection 2020.
Li Y, He M, Zhang W, Yang M, Ding Y, Xu S, Gu J, Li Y, Yin J, Gao Y.

Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms. (Human mesenchymal stem cells, humanized mice, NOG )
World J Stem Cells. 2020 Sep 26;12(9):1032-1049. doi: 10.4252/wjsc.v12.i9.1032.
Song Y, Lim JY, Lim T, Im KI, Kim N, Nam YS, Jeon YW, Shin JC, Ko HS, Park IY, Cho SG.

2019年度

Comparison of biological features between severely immuno-deficient NOD/Shi-scid Il2rg null and NOD/LtSz-scidIl2rg null mice. (NOG, BG data)
Exp Anim. 2019 Nov 6;68(4):471-482. doi: 10.1538/expanim.19-0024. Epub 2019 May 21.
Mariko Nagatani, Tsutomu Kodera, Daisuke Suzuki, Saori Igura, Yachiyo Fukunaga, Hiroyuki Kanemitsu, Daichi Nakamura, Masahiro Mochizuki, Masayuki Kemi, Kazutoshi Tamura, Kenichiro Kasahara

Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone. (Bone metastases, humanized mice, NOG)
J Immunol Res. 2019 May 9;2019:4260987. doi: 10.1155/2019/4260987. eCollection 2019.
Kähkönen TE, Suominen MI, Mäki-Jouppila JHE, Halleen JM, Tanaka A, Seiler M, Bernoulli J.

MTBHsp70-exFPR1-pulsed Dendritic Cells Enhance the Immune Response against Cervical Cancer. (Cervical Cancer, Dendritic cells, NOG)
J Cancer. 2019 Oct 19;10(25):6364-6373. doi: 10.7150/jca.29779. eCollection 2019.
Cao G, Cui R, Liu C, Zhang G, Zhang Z.

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice.(Multiple myeloma, Bone Marrow Imaging, NOG)
J Vis Exp. 2019 Jan 7;(143):10.3791/58056. doi: 10.3791/58056.
Gastelum G, Chang EY, Shackleford D, Bernthal N, Kraut J, Francis K, Smutko V, Frost P.

Increased Granulopoiesis in the Bone Marrow following Epstein-Barr Virus Infection. (EBV, humanized mice, NOG)
Sci Rep. 2019 Sep 17;9(1):13445. doi: 10.1038/s41598-019-49937-w.
Katahira Y, Higuchi H, Matsushita H, Yahata T, Yamamoto Y, Koike R, Ando K, Sato K, Imadome KI, Kotani A.

Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy (Cancer immune therapy, NOG)
Nano Lett. 2019 May 8;19(5):2774-2783. doi: 10.1021/acs.nanolett.8b04296. Epub 2019 Apr 5.
Zhang YX, Zhao YY, Shen J, Sun X, Liu Y, Liu H, Wang Y, Wang J.

Inhibition of Notch Signaling Enhances Chemosensitivity in B-cell Precursor Acute Lymphoblastic Leukemia (B-cell Precursor Acute Lymphoblastic Leukemia, NOG).
Cancer Res. 2019 Feb 1;79(3):639-649. doi: 10.1158/0008-5472.CAN-18-1617. Epub 2018 Dec 18.
Takam Kamga P, Dal Collo G, Midolo M, Adamo A, Delfino P, Mercuri A, Cesaro S, Mimiola E, Bonifacio M, Andreini A, Chilosi M, Krampera M.

Abscopal effect when combining oncolytic adenovirus and checkpoint inhibitor in a humanized NOG mouse model of melanoma. (Cancer immunotherapy, humanized mice, NOG).
J Med Virol. 2019 Sep;91(9):1702-1706. doi: 10.1002/jmv.25501. Epub 2019 Jun 24.
Kuryk L, Møller AW, Jaderberg M.

Alloreactive T Cells Display a Distinct Chemokine Profile in Response to Conditioning in Xenogeneic GVHD Models.(GVHD models, NOG, NOG-ΔMHC)
Transplantation. 2019 Sep;103(9):1834-1843. doi:10.1097/TP.0000000000002756.
Kawasaki Y, Sato K, Nakano H, Hayakawa H, Izawa J, Takayama N, Mashima K, Oh I, Minakata D, Yamasaki R, Morita K, Ashizawa M, Yamamoto C, Hatano K, Fujiwara SI, Ohmine K, Muroi K, Ito R, Hayakawa M, Ohmori T, Kanda Y.

The Preconditioning of Busulfan Promotes Efficiency of Human CD133+ Cells Engraftment in NOD Shi-SCID IL2Rγcnull (NOG) Mice via Intra-Bone Marrow Injection. (CD133+ Cells engraftment, humanized mice, NOG)
Cell Transplant. 2019 Jul;28(7):973-979. doi: 10.1177/0963689719842162. Epub 2019 Apr 15.
Guo X, Yin X, Zhu W, Pan Y, Wang H, Liang Y, Zhu X

HTLV-1 Extracellular Vesicles Promote Cell-to-Cell Contact. (HTLV-1, humanized mice, NOG)
Front Microbiol. 2019 Sep 18;10:2147. doi: 10.3389/fmicb.2019.02147. eCollection 2019.
Pinto DO, DeMarino C, Pleet ML, Cowen M, Branscome H, Al Sharif S, Jones J, Dutartre H, Lepene B, Liotta LA, Mahieux R, Kashanchi F.

Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma.(Uveal melanoma, NOG)
Mol Cancer 2019 Sep 16;18(1):140. doi: 10.1186/s12943-019-1070-7.
Jing Zhang, Shenglan Liu, Qianyun Ye, Jingxuan Pan

Optimized Xenograft Protocol for Chronic Lymphocytic Leukemia Results in High Engraftment Efficiency for All CLL Subgroups. (CLL, NOG, BRG)
Int J Mol Sci. 2019 Dec 12;20(24):6277. doi: 10.3390/ijms20246277.
Sarah Decker, Anabel Zwick, Shifa Khaja Saleem, Sandra Kissel, Andres Rettig, Konrad Aumann, Christine Dierks

cAIMP administration in humanized mice induces a chimerization-level-dependent STING response. (humanized mice, NOG)
Immunology. 2019 Jun;157(2):163-172. doi: 10.1111/imm.13061. Epub 2019 May 6.
Andersen AHF, Olesen R, Jønsson KL, Højen JF, Krapp C, Mack K, Thomsen MK, Østergaard L, Tolstrup M, Dagnaes-Hansen F, Jakobsen MR, Denton PW.

Increased SLAMF7high monocytes in myelofibrosis patients harboring JAK2 V617F provide a therapeutic target of elotuzumab. (humanized mice, NOG, myelofibrosis, elotuzmab)
Blood. 2019 Sep 5;134(10):814-825. doi: 10.1182/blood.2019000051. Epub 2019 Jul 3.
Maekawa T, Kato S, Kawamura T, Takada K, Sone T, Ogata H, Saito K, Izumi T, Nagao S, Takano K, Okada Y, Tachi N, Teramoto M, Horiuchi T, Hikota-Saga R, Endo-Umeda K, Uno S, Osawa Y, Kobayashi A, Kobayashi S, Sato K, Hashimoto M, Suzu S, Usuki K, Morishita S, Araki M, Makishima M, Komatsu N, Kimura F.

CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis. (Liver cancer, CD73 function, NOG)
J Hematol Oncol. 2019 Apr 11;12(1):37. doi: 10.1186/s13045-019-0724-7.
Xiao-Lu Ma, Min-Na Shen, Bo Hu, Bei-Li Wang, Wen-Jing Yang, Li-Hua Lv, Hao Wang, Yan Zhou, An-Li Jin, Yun-Fan Sun, Chuan-Yan Zhang, Shuang-Jian Qiu, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo

Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit (humanized mice, NOG, Cancer Immune therapy)
MAbs. 2019 Nov-Dec;11(8):1443-1451. doi: 10.1080/19420862.2019.1654303. Epub 2019 Sep 3.
Jie Wang, Keke Fei, Hua Jing, Zhihai Wu, Weiwei Wu, Shuaixiang Zhou, Haiqing Ni, Bingliang Chen, Yan Xiong, Yanpeng Liu, Bo Peng, Dechao Yu, Haiping Jiang, Junjian Liu

2018年度

Tumorigenicity-associated characteristics of human iPS cell lines. (Tumorigenicity test, NOG)
PLoS One. 2018 Oct 4;13(10):e0205022. doi: 10.1371/journal.pone.0205022. eCollection 2018.
Satoshi Yasuda, Shinji Kusakawa, Takuya Kuroda, Takumi Miura, Keiko Tano, Nozomi Takada, Satoko Matsuyama, Akifumi Matsuyama, Michiyo Nasu, Akihiro Umezawa, Takao Hayakawa, Hideki Tsutsumi, Yoji Sato

Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions. (Cervical cancer)
Oncogenesis. 2018 Jan 23;7(1):4. doi: 10.1038/s41389-017-0018-2.
Zhang Q, Wang H, Li H, Xu J, Tian K, Yang J, Lu Z, Zheng J.

Development of the next generation humanized mouse for drug discovery (Next generation NOG, Japanese)
Nihon Yakurigaku Zasshi. 2018;151(4):160-165. doi: 10.1254/fpj.151.160.]
Ryoji Ito,

Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model.(Cancer immunotherapy )
Oncoimmunology. 2018 Apr 18;7(8):e1450715. doi: 10.1080/2162402X.2018.1450715. eCollection 2018.
Idorn M, Skadborg SK, Kellermann L, Halldórsdóttir HR, Holmen Olofsson G, Met Ö, Thor Straten P.

Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions (Lung cancer)
Cancer Sci. 2018 Oct;109(10):3149-3158. doi: 10.1111/cas.13752. Epub 2018 Sep 11.
Kato Y, Ninomiya K, Ohashi K, Tomida S, Makimoto G, Watanabe H, Kudo K, Matsumoto S, Umemura S, Goto K, Ichihara E, Ninomiya T, Kubo T, Sato A, Hotta K, Tabata M, Toyooka S, Maeda Y, Kiura K.

Immunologic targeting of CD30 eliminates tumorigenic human pluripotent stem cells, allowing safer clinical application of hiPSC-based cell therapy. (tumorigenic human pluripotent stem cells)
Sci Rep. 2018 Feb 27;8(1):3726. doi: 10.1038/s41598-018-21923-8.
Sougawa N, Miyagawa S, Fukushima S, Kawamura A, Yokoyama J, Ito E, Harada A, Okimoto K, Mochizuki-Oda N, Saito A, Sawa Y.

Combination of immunogenic oncolytic adenovirus ONCOS-102 with anti-PD-1 pembrolizumab exhibits synergistic antitumor effect in humanized A2058 melanoma huNOG mouse model (Cancer immune therapy).
Oncoimmunology. 2018 Oct29;8(2):e1532763. doi:10.1080/2162402X.2018.1532763. eCollection 2019.
Kuryk L, Møller AW, Jaderberg M.

High-sensitivity Detection of Micrometastases Generated by GFP Lentivirus-transduced Organoids Cultured from a Patient-derived Colon Tumor.
J Vis Exp. 2018 Jun 14;(136):57374. doi: 10.3791/57374.
Yu Okazawa, Kosuke Mizukoshi, Yu Koyama, Shoki Okubo, Hiromitsu Komiyama, Yutaka Kojima, Michitoshi Goto, Sonoko Habu, Okio Hino, Kazuhiro Sakamoto, Akira Orimo

Establishment of a Patient-Derived Tumor Xenograft Model and Application for Precision Cancer Medicine.
Chem Pharm Bull (Tokyo). 2018;66(3):225-230. doi: 10.1248/cpb.c17-00789.
Seiji Okada, KulthidaVaeteewoottacharn, Ryusho Kariya

Enhanced Antibody Responses in a Novel NOG Transgenic Mouse with Restored Lymph Node Organogenesis. (Antibody response)
Front Immunol. 2018 Jan 17;8:2017. doi: 10.3389/fimmu.2017.02017. eCollection 2017.
Takahashi T, Katano I, Ito R, Goto M, Abe H, Mizuno S, Kawai K, Sugiyama F, Ito M.

Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation.
Stem Cell Reports. 2018 Mar 13;10(3):1059-1074. doi: 10.1016/j.stemcr.2018.01.032. Epub 2018 Mar 1.
Iraha S, Tu HY, Yamasaki S, Kagawa T, Goto M, Takahashi R, Watanabe T, Sugita S, Yonemura S, Sunagawa GA, Matsuyama T, Fujii M, Kuwahara A, Kishino A, Koide N, Eiraku M, Tanihara H, Takahashi M, Mandai M.

Characterization of a new B-ALL cell line with constitutional defect of the Notch signaling pathway.(B-ALL)
Oncotarget. 2018 Apr 6;9(26):18341-18350. doi: 10.18632/oncotarget.24836.
Kamga PT, Dal Collo G, Bassi G, Midolo M, Delledonne M, Chilosi M, Bonifacio M, Krampera M.

Influence of the three-dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3.(osteogenesis)
J Tissue Eng Regen Med. 2018 Apr;12(4):e1936-e1949. doi: 10.1002/term.2625. Epub 2018 Jan 8.
Guerrero J, Oliveira H, Aid R, Bareille R, Siadous R, Letourneur D, Mao Y, Kohn J, Amédée J.

2017年度

Background data on NOD/Shi scid IL 2R γ null mice (NOG mice).
J Toxicol Sci. 2017;42(6):689-705. doi: 10.2131/jts.42.689.
Kenichiro Kasahara, Yachiyo Fukunaga, Saori Igura, Rie Andoh, Tsubasa Saito, Isamu Suzuki, Hiroyuki Kanemitsu Daisuke Suzuki, Ken Goto, Daichi Nakamura, Masahiro Mochizuki, Masahiko Yasuda, Ryo Inoue, Kazutoshi Tamura, Mariko Nagatani

Incidence of spontaneous lymphomas in non-experimental NOD/Shi-scid, IL-2Rγ null (NOG) mice.
Exp Anim. 2017 Oct 30;66(4):425-435. doi: 10.1538/expanim.17-0034. Epub 2017 Jul 6.
Masahiko Yasuda, Tomoyuki Ogura, Takayuki Goto, Mika Yagoto, Yoko Kamai, Chie Shimomura, Nobuhito Hayashimoto, Yukito Kiyokawa, Hideki Shinohara, Riichi Takahashi, Kenji Kawai

Chimeric antigen receptor-modified T Cells inhibit the growth and metastases of established tissue factor-positive tumors in NOG mice. (CAR-T)
Oncotarget. 2017 Feb 7;8(6):9488-9499. doi: 10.18632/oncotarget.14367.
Qing Zhang, Haiyu Wang, Huizhong Li, Jinjing Xu, Kang Tian, Jie Yang, Zheng Lu, Junnian Zheng

Irradiation strongly reduces tumorigenesis of human induced pluripotent stem cells. (Pluripotent stem cells, tumorigenesis)
J Radiat Res. 2017 Jul 1;58(4):430-438. doi: 10.1093/jrr/rrw124.
Inui S, Minami K, Ito E, Imaizumi H, Mori S, Koizumi M, Fukushima S, Miyagawa S, Sawa Y, Matsuura N.

MtHsp70-CLIC1-pulsed dendritic cells enhance the immune response against ovarian cancer. (Ovarian Cancer)
Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):13-19. doi: 10.1016/j.bbrc.2017.10.094. Epub 2017 Oct 20.
Yu W, Qu H, Cao G, Liu C, Deng H, Zhang Z.

Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma. (ATL)
Blood. 2017 Aug 31;130(9):1114-1124. doi: 10.1182/blood-2016-09-741983. Epub 2017 Jun 23.
Narita T, Ishida T, Ito A, Masaki A, Kinoshita S, Suzuki S, Takino H, Yoshida T, Ri M, Kusumoto S, Komatsu H, Imada K, Tanaka Y, Takaori-Kondo A, Inagaki H, Scholz A, Lienau P, Kuroda T, Ueda R, Iida S

Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. (ATL)
Cancer Sci. 2017 Mar;108(3):435-443. doi: 10.1111/cas.13163.
Nasu K, Yamaguchi K, Takanashi T, Tamai K, Sato I, Ine S, Sasaki O, Satoh K, Tanaka N, Tanaka Y, Fukushima T, Harigae H, Sugamura K.

Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/β-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. (CML)
Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
Jin B, Wang C, Li J, Du X, Ding K, Pan J.

Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts(CLL)
Oncotarget. 2017 Jul 4;8(27):44749-44760. doi: 10.18632/oncotarget.17432.
Davies NJ, Kwok M, Gould C, Oldreive CE, Mao J, Parry H, Smith E, Agathanggelou A, Pratt G, Taylor AMR, Moss P, Griffiths M, Stankovic T.

CD34 Antigen and the MPL Receptor Expression Defines a Novel Class of Human Cord Blood-Derived Primitive Hematopoietic Stem Cells.
Cell Transplant. 2017 Jun 9;26(6):1043-1058.
Yoshikazu Matsuoka, Masaya Takahashi, Keisuke Sumide, Hiroshi Kawamura, Ryusuke Nakatsuka, Tatsuya Fujioka, Yoshiaki Sonoda

Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model.
Nat Commun. 2017 Sep 27;8(1):707. doi: 10.1038/s41467-017-00786-z.
Jespersen H, Lindberg MF, Donia M, Söderberg EMV, Andersen R, Keller U, Ny L, Svane IM, Nilsson LM, Nilsson JA.

Humanized NOG mice as a model for tuberculosis vaccine-induced immunity: a comparative analysis with the mouse and guinea pig models of tuberculosis.
Immunology. 2017 Sep;152(1):150-162.
Ajay Grover, Amber Troy, Jenny Rowe, JoLynn M Troudt, Elizabeth Creissen, Jennifer McLean 1, Prabal Banerjee, Gerold Feuer, Angelo A Izzo

Human fetal liver cultures support multiple cell lineages that can engraft immunodeficient mice.
Open Biol. 2017 Dec;7(12):170108.
Marina E Fomin, Ashley I Beyer, Marcus O Muench

Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells.
Stem Cell Res. 2017 May;21:32-39.
Xuejia Li, Chengxiang Xia, Tongjie Wang, Lijuan Liu, Qianhao Zhao, Dan Yang, Fangxiao Hu, Mengyun Zhang, Ke Huang, Yang Geng, Yi Zheng, Yuxian Guan, Hongling Wu, Xiaoli Chen, Guangjin Pan, Jiekai Chen, Juan Du, Jinyong Wang

Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/β-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia.
Clin Cancer Res. 2017 Feb 1;23(3):789-803.
Bei Jin, Chengyan Wang, Juan Li, Xin Du, Ke Ding, Jingxuan Pan

Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts.
Oncotarget . 2017 Jul 4;8(27):44749-44760. doi: 10.18632/oncotarget.17432.
Nicholas J Davies, Marwan Kwok, Clive Gould, Ceri E Oldreive, Jingwen Mao, Helen Parry, Edward Smith, Angelo Agathanggelou, Guy Pratt, Alexander Malcolm R Taylor, Paul Moss, Mike Griffiths, Tatjana Stankovic

Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model.
Nat Commun . 2017 Sep 27;8(1):707. doi: 10.1038/s41467-017-00786-z.
Henrik Jespersen, Mattias F Lindberg, Marco Donia, Elin M V Söderberg, Rikke Andersen, Ulrich Keller, Lars Ny, Inge Marie Svane, Lisa M Nilsson, Jonas A Nilsson

Comparison of the Gene Expression Profiles of Human Hematopoietic Stem Cells between Humans and a Humanized Xenograft Model.
Tokai J Exp Clin Med. 2017 Apr 20;42(1):41-51.
Hideyuki Matsuzawa, Hiromichi Matsushita, Takashi Yahata, Masayuki Tanaka, Kiyoshi Ando

A Novel Xenogeneic Graft-Versus-Host Disease Model for Investigating the Pathological Role of Human CD4 + or CD8 + T Cells Using Immunodeficient NOG Mice. (GVHD model)
Am J Transplant. 2017 May;17(5):1216-1228. doi: 10.1111/ajt.14116. Epub 2016 Dec 21.
Ito R, Katano I, Kawai K, Yagoto M, Takahashi T, Ka Y, Ogura T, Takahashi R, Ito M.

Proliferative Cartilaginous Lesions in the Calcaneal Tendons of huNOG Mice. (NOG pathology)
Toxicol Pathol. 2017 Oct;45(7):952-956. doi: 10.1177/0192623317734822. Epub 2017 Oct 3.
MacLeod AM, Treuting PM, Carlson CS.

Comparison of the Gene Expression Profiles of Human Hematopoietic Stem Cells between Humans and a Humanized Xenograft Model. (humanized mice, gene expression)
Tokai J Exp Clin Med. 2017 Apr 20;42(1):41-51.
Matsuzawa H, Matsushita H, Yahata T, Tanaka M, Ando K.

Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells.
Stem Cell Res. 2017 May;21:32-39. doi: 10.1016/j.scr.2017.03.014. Epub 2017 Mar 21.
Li X, Xia C, Wang T, Liu L, Zhao Q, Yang D, Hu F, Zhang M, Huang K, Geng Y, Zheng Y, Guan Y, Wu H, Chen X, Pan G, Chen J, Du J, Wang J.

Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. (ATL derived cells)
Cancer Sci. 2017 Mar;108(3):435-443. doi: 10.1111/cas.13163.
Nasu K, Yamaguchi K, Takanashi T, Tamai K, Sato I, Ine S, Sasaki O, Satoh K, Tanaka N, Tanaka Y, Fukushima T, Harigae H, Sugamura K.

Chimeric antigen receptor-modified T Cells inhibit the growth and metastases of established tissue factor-positive tumors in NOG mice.
Oncotarget. 2017 Feb 7;8(6):9488-9499. doi: 10.18632/oncotarget.14367.
Qing Zhang, Haiyu Wang, Huizhong Li, Jinjing Xu, Kang Tian, Jie Yang, Zheng Lu, Junnian Zheng

2016年度

A Novel Carcinoembryonic Antigen T Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors. (T Cell Bispecific Antibody )
Clin Cancer Res. 2016 Jul 1;22(13):3286 97. doi: 10.1158/1078 0432.CCR 15 1696. Epub 2016 Feb 9.
Marina Bacac, Tanja Fauti, Johannes Sam, Sara Colombetti, Tina Weinzierl, Djamila Ouaret, Walter Bodmer, Steffi Lehmann, Thomas Hofer, Ralf J Hosse, Ekkehard Moessner, Oliver Ast, Peter Bruenker, Sandra Grau-Richards, Teilo Schaller, Annette Seidl, Christian Gerdes, Mario Perro, Valeria Nicolini, Nathalie Steinhoff, Sherri Dudal, Sebastian Neumann, Thomas von Hirschheydt, Christiane Jaeger, Jose Saro , Vaios Karanikas, Christian Klein, Pablo Umaña

Murine Models of Epstein-Barr Virus-Associated Lymphomagenesis. (EBV)
ILAR J. 2016;57(1):55-62. doi: 10.1093/ilar/ilv074.
Ahmed EH, Baiocchi RA.

h-prune affects anaplastic thyroid cancer invasion and metastasis. (Thyroid cancer metastasis)
Oncol Rep. 2016 Jun;35(6):3445-52. doi: 10.3892/or.2016.4759. Epub 2016 Apr 20.
Nambu J, Kobayashi T, Hashimoto M, Tashiro H, Sugino K, Shimamoto F, Kikuchi A, Ohdan H.

Development of DS-5573a: A novel afucosylated mAb directed at B7-H3 with potent antitumor activity.(Anti tumor)
Cancer Sci. 2016 May;107(5):674-81. doi: 10.1111/cas.12915. Epub 2016 Apr 26.
Nagase-Zembutsu A, Hirotani K, Yamato M, Yamaguchi J, Takata T, Yoshida M, Fukuchi K, Yazawa M, Takahashi S, Agatsuma T.

Sensitive Tumorigenic Potential Evaluation of Adult Human Multipotent Neural Cells Immortalized by hTERT Gene Transduction. (tumorigeneici test)
PLoS One. 2016 Jul 8;11(7):e0158639. doi:10.1371/journal.pone.0158639. eCollection 2016.
Lee KH, Nam H, Jeong da E, Kim SS, Song HJ, Pyeon HJ, Kang K, Hong SC, Nam DH, Joo KM.

Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation.(ATL).
Cancer Sci. 2016 May;107(5):638-43. doi: 10.1111/cas.12921. Epub 2016 Apr 7.
Yamaguchi K, Takanashi T, Nasu K, Tamai K, Mochizuki M, Satoh I, Ine S, Sasaki O, Satoh K, Tanaka N, Harigae H, Sugamura K.

Efficient Regeneration of Human Vα24 + Invariant Natural Killer T Cells and Their Anti-Tumor Activity In Vivo. (NKT, anti-tumor activity )
Stem Cells. 2016 Dec;34(12):2852-2860. doi: 10.1002/stem.2465. Epub 2016 Aug 1.
Yamada D, Iyoda T, Vizcardo R, Shimizu K, Sato Y, Endo TA, Kitahara G, Okoshi M, Kobayashi M, Sakurai M, Ohara O, Taniguchi M, Koseki H, Fujii SI.

Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with Imatinib(CML)
Theranostics. 2016 Aug 12;6(11):1947-62. doi: 10.7150/thno.16139. eCollection 2016.
Jin Y, Yao Y, Chen L, Zhu X, Jin B, Shen Y, Li J, Du X, Lu Y, Jiang S, Pan J.

Histone modifications patterns in tissues and tumours from acute promyelocytic leukemia xenograft model in response to combined epigenetic therapy (acute promyelocytic leukemia)
Biomed Pharmacother. 2016 Apr;79:62-70. doi: 10.1016/j.biopha.2016.01.044. Epub 2016 Feb 16.
Valiulienė G, Treigytė G, Savickienė J, Matuzevičius D, Alksnė M, Jarašienė-Burinskaja R, Bukelskienė V, Navakauskas D, Navakauskienė R.

Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. (EBV).
Oncotarget. 2016 Nov 22;7(47):76793-76805. doi: 10.18632/oncotarget.12529.
Ando S, Kawada JI, Watanabe T, Suzuki M, Sato Y, Torii Y, Asai M, Goshima F, Murata T, Shimizu N, Ito Y, Kimura H.

Antitumor effects of minodronate, a third-generation nitrogen-containing bisphosphonate, in synergy with γδT cells in human glioblastoma in vitro and in vivo. (glioblastoma).
J Neurooncol. 2016 Sep;129(2):231-41. doi: 10.1007/s11060-016-2186-x. Epub 2016 Jul 8.
Nakazawa T, Nakamura M, Matsuda R, Nishimura F, Park YS, Motoyama Y, Hironaka Y, Nakagawa I,

Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells. (Lung cancer).
Biochem Biophys Res Commun. 2016 Apr 22;473(1):125-132. doi:10.1016/j.bbrc.2016.03.064. Epub 2016 Mar 17.
Kobayashi I, Takahashi F, Nurwidya F, Nara T, Hashimoto M, Murakami A, Yagishita S, Tajima K, Hidayat M, Shimada N, Suina K, Yoshioka Y, Sasaki S, Moriyama M, Moriyama H, Takahashi K.

Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with Imatinib.
Theranostics. 2016 Aug 12;6(11)
Yanli Jin, Yiwu Yao, Li Chen, Xiaohui Zhu, Bei Jin, Yingying Shen, Juan Li, Xin Du, Yuhong Lu, Sheng Jiang, Jingxuan Pan

A Novel Carcinoembryonic Antigen T Cell Bispecific Antibody (CEA TCB) For The Treatment Of Solid Tumors.
Clin Cancer Res. 2016 Jul 1;22(13):3286-97. doi: 10.1158/1078-0432.CCR-15-1696. Epub 2016 Feb 9.
Bacac M, Fauti T, Sam J, Colombetti S, Weinzierl T, Ouaret D, Bodmer WF, Lehmann S, Hofer T, Hosse RJ, Moessner E, Ast O, Bruenker P, Grau-Richards S, Schaller T, Seidl A, Gerdes CA, Perro M, Nicolini V, Steinhoff N, Dudal S, Neumann S, von Hirschheydt T, Jaeger C, Saro J, Karanikas V, Klein C, Umana P.

Establishment and characterisation of patient-derived xenografts as paraclinical models for gastric cancer.
Sci Rep. 2016 Mar 1;6:22172. doi: 10.1038/srep22172.
Yoon Young Choi, Jae Eun Lee, Hyunki Kim, Moon Hee Sim, Ka-Kyung Kim, Gunho Lee, Hyoung-Il Kim, Ji Yeong An, Woo Jin Hyung, Choong-Bai Kim, Sung Hoon Noh, Sangwoo Kim, Jae-Ho Cheong

Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines. (humanized mice, Donor Dependent Variations, ES, iPS, MSC)
PLoS One. 2016 Mar 3;11(3):e0149291. doi: 10.1371/journal.pone.0149291. eCollection 2016.
Féraud O, Valogne Y, Melkus MW, Zhang Y, Oudrhiri N, Haddad R, Daury A, Rocher C, Larbi A, Duquesnoy P, Divers D, Gobbo E, Brunet de la Grange P, Louache F, Bennaceur-Griscelli A, Mitjavila-Garcia MT.

Heat Shock Enhances the Expression of the Human T Cell Leukemia Virus Type-I (HTLV-I) Trans-Activator (Tax) Antigen in Human HTLV-I Infected Primary and Cultured T Cells. (HTLV-1)
Viruses. 2016 Jul 11;8(7):191. doi: 10.3390/v8070191.
Kunihiro M, Fujii H, Miyagi T, Takahashi Y, Tanaka R, Fukushima T, Ansari AA, Tanaka Y.

A Potential of an Anti-HTLV-I gp46 Neutralizing Monoclonal Antibody (LAT-27) for Passive Immunization against Both Horizontal and Mother-to-Child Vertical Infection with Human T Cell Leukemia Virus Type-I. (HTLV-1)
Viruses. 2016 Feb 3;8(2):41. doi: 10.3390/v8020041.
Fujii H, Shimizu M, Miyagi T, Kunihiro M, Tanaka R, Takahashi Y, Tanaka Y.

Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines. (humanized mice, Donor Dependent Variations, ES, iPS, MSC, NOG)
PLoS One. 2016 Mar 3;11(3):e0149291. doi: 10.1371/journal.pone.0149291. eCollection 2016.
Féraud O, Valogne Y, Melkus MW, Zhang Y, Oudrhiri N, Haddad R, Daury A, Rocher C, Larbi A, Duquesnoy P, Divers D, Gobbo E, Brunet de la Grange P, Louache F, Bennaceur-Griscelli A, Mitjavila-Garcia MT.

2015年度

Early development of human lymphomas in a prostate cancer xenograft program using triple knock out immunocompromised mice. (Prostate cancer, PDX)
Prostate. 2015 May;75(6):585 92. doi: 10.1002/pros.22939. Epub 2015 Jan 13.
Christian Wetterauer, Tatjana Vlajnic, Julia Schüler, Joel R Gsponer, George N Thalmann, Marco Cecchini, Julia Schneider, Tobias Zellweger, Heike Pueschel, Alexander Bachmann, Christian Ruiz, Stephan Dirnhofer, Lukas Bubendorf, Cyrill A Rentsch

The status of donor cancer tissues affects the fate of patient-derived colorectal cancer xenografts in NOG mice. (PDX, colorectal cancer )
Exp Anim. 2015;64(2):181-90. doi: 10.1538/expanim.14-0080. Epub 2015 Jan 26.
Etsuko Fujii, Atsuhiko Kato, Yu Jau Chen, Koichi Matsubara, Yasuyuki Ohnishi, Masami Suzuki

Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia. (ATL)
Retrovirology. 2015 Nov 24;12:99. doi: 10.1186/s12977-015-0225-x.
Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T.

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry. (Cancer cells, imaging)
Nitric Oxide. 2015 Apr 30;46:102-13. doi: 10.1016/j.niox.2014.11.005. Epub 2014 Nov 11.
Mitsuyo Ohmura, Takako Hishiki, Takehiro Yamamoto, Tsuyoshi Nakanishi, Akiko Kubo, Kenji Tsuchihashi, Mayumi Tamada, Sakino Toue, Yasuaki Kabe, Hideyuki Saya, Makoto Suematsu

CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody.(ADCC, ADCP).
Cancer Sci. 2015 Oct;106(10):1474-8. doi: 10.1111/cas.12738.
Hiramatsu K, Serada S, Kobiyama K, Nakagawa S, Morimoto A, Matsuzaki S, Ueda Y, Fujimoto M, Yoshino K, Ishii KJ, Enomoto T, Kimura T, Naka T.

Evaluation of in vivo antitumor effects of ANT2 shRNA delivered using PEI and ultrasound with microbubbles. (shRNA Antitumor effects)
Gene Ther. 2015 Apr;22(4):325-32. doi: 10.1038/gt.2014.120. Epub 2015 Jan 15.
Park DH, Jung BK, Lee YS, Jang JY, Kim MK, Lee JK, Park H, Seo J, Kim CW.

Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype. (HIV1)
J Virol. 2015 Sep;89(17):9080-9. doi: 10.1128/JVI.00983-15. Epub 2015 Jun 24.
Shigemura T, Shiohara M, Kato M, Furuta S, Kaneda K, Morishita K, Hasegawa H, Fujii M, Gorlach A, Koike K, Kamata T.

Preclinical pharmacologic evaluation of pralatrexate and romidepsin confirms potent synergy of the combination in a murine model of human T-cell lymphoma (T cell lymphoma).
Clin Cancer Res. 2015 May 1;21(9):2096-106. doi: 10.1158/1078-0432.CCR-14-2249. Epub 2015 Feb 12.
Jain S, Jirau-Serrano X, Zullo KM, Scotto L, Palermo CF, Sastra SA, Olive KP, Cremers S, Thomas T, Wei Y,

Common marmoset CD117+ hematopoietic cells possess multipotency.
Int Immunol. 2015 Nov;27(11):567-77.
Shin Shimada, Satoshi Nunomura, Shuya Mori, Hiroshi Suemizu, Toshio Itoh, Shuji Takabayashi, Yoshinori Okada, Takashi Yahata, Takashi Shiina, Hideki Katoh, Ryuji Suzuki, Kenzaburo Tani, Kiyoshi Ando, Hideo Yagita, Sonoko Habu, Erika Sasaki, Yoshie Kametani

Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.
PLoS One. 2015 Jul 10;10(7):e0132041.
Changshan Wang, Motohiko Oshima, Goro Sashida, Takahisa Tomioka, Nagisa Hasegawa, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Yoichiro Kusunoki, Seishi Kyoizumi, Kazue Imai, Kei Nakachi, Atsushi Iwama

Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes.
PLoS One. 2015 Sep 1;10(9):e0136851. doi: 10.1371/journal.pone.0136851. eCollection 2015.
McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F.

Committing Cytomegalovirus-Specific CD8 T Cells to Eliminate Tumor Cells by Bifunctional Major Histocompatibility Class I Antibody Fusion Molecules.
Cancer Immunol Res. 2015 Jul;3(7):764-76. doi: 10.1158/2326-6066.CIR-15-0037. Epub 2015 Feb 17.
Schmittnaegel M, Levitsky V, Hoffmann E, Georges G, Mundigl O, Klein C, Knoetgen H.

CEA TCB, A novel T-cell bispecific antibody with potent in vitro and in vivo antitumour activity against solid tumours.
European Journal of CancerVolume 51, Supplement 1,March 2015, Page S13
Bacac M, Fauti T, Colombetti S, Sam J, Nicolini V, Steinhoff N, Ast O, Bruenker P, Hosse R, Hofer T, Moessner E, Jaeger C, Saro J, Karanikas V, Klein C, Umana P.

Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia.
Retrovirology. 2015 Nov 24;12:99. doi: 10.1186/s12977-015-0225-x.
Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T.

The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells.
Cancers (Basel). 2015 May 22;7(2):876-907. doi: 10.3390/cancers7020814.
Gomez-Casal R, Bhattacharya C, Epperly MW, Basse PH, Wang H, Wang X, Proia DA, Greenberger JS, Socinski MA, Levina V.

Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells.
J Virol. 2015 Jul;89(14):7016-27. doi: 10.1128/JVI.00716-15. Epub 2015 Apr 29.
Kondo Y, Kimura O, Tanaka Y, Ninomiya M, Iwata T, Kogure T, Inoue J, Sugiyama M, Morosawa T, Fujisaka Y, Shimosegawa T.

Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia.
Retrovirology. 2015 Nov 24;12:99. doi: 10.1186/s12977-015-0225-x.
Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T.

Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.
J Pharmacol Exp Ther. 2015 Mar;352(3):579-89. doi:10.1124/jpet.114.221150. Epub 2015 Jan 9.
Rudolph D, Impagnatiello MA, Blaukopf C, Sommer C, Gerlich DW, Roth M, Tontsch-Grunt U, Wernitznig A, Savarese F, Hofmann MH, Albrecht C, Geiselmann L, Reschke M, Garin-Chesa P, Zuber J, Moll J, Adolf GR, Kraut N.

Osteopontin integrin interaction as a novel molecular target for antibody mediated immunotherapy in adult T cell leukemia.
Retrovirology. 12:99 .
Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T.

Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.
J Pharmacol Exp Ther. 352(3):579-89.
Rudolph D, Impagnatiello MA, Blaukopf C, Sommer C, Gerlich DW, Roth M, Tontsch-Grunt U, Wernitznig A, Savarese F, Hofmann MH, Albrecht C, Geiselmann L, Reschke M, Garin-Chesa P, Zuber J, Moll J, Adolf GR, Kraut N.

Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity.
J Immunol. 2015 Jul 13. pii: 1402103. [Epub ahead of print]
Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M.

MicroRNA-16 mediates the regulation of a senescence-apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas.
Oncogenem advance online publication, 7 Dec 2015 (doi: 10.1038/onc.2015.435).
Kitadate A, Ikeda S, Teshima K, Ito M, Toyota I, Hasunuma N, Takahashi N, Miyagaki T, Sugaya M, Tagawa H.

Early development of human lymphomas in a prostate cancer xenograft program using triple knock-out immunocompromised mice.
Prostate. 2015 May;75(6):585-92. doi: 10.1002/pros.22939. Epub 2015 Jan 13.
Christian Wetterauer 1, Tatjana Vlajnic, Julia Schüler, Joel R Gsponer, George N Thalmann, Marco Cecchini, Julia Schneider, Tobias Zellweger, Heike Pueschel, Alexander Bachmann, Christian Ruiz, Stephan Dirnhofer, Lukas Bubendorf, Cyrill A Rentsch

Spontaneous Post-Transplant Disorders in NOD.Cg- Prkdcscid Il2rgtm1Sug /JicTac (NOG) Mice Engrafted with Patient-Derived Metastatic Melanomas.
https://doi.org/10.1371/journal.pone.0124974
Enrico Radaelli, Els Hermans, Lorna Omodho, Annick Francis, Sara Vander Borght, Jean-Christophe Marine, Joost van den Oord, Frédéric Amant

The status of donor cancer tissues affects the fate of patient-derived colorectal cancer xenografts in NOG mice.
Exp Anim. 2015;64(2):181-90. doi: 10.1538/expanim.14-0080. Epub 2015 Jan 26.
Etsuko Fujii, Atsuhiko Kato, Yu Jau Chen, Koichi Matsubara, Yasuyuki Ohnishi, Masami Suzuki

Establishment of patient-derived cancer xenografts in immunodeficient NOG mice.
Int J Oncol. 2015 Jul;47(1):61-70. doi: 10.3892/ijo.2015.2997. Epub 2015 May 11.
Chijiwa T, Kawai K, Noguchi A, Sato H, Hayashi A, Cho H, Shiozawa M, Kishida T, Morinaga S, Yokose T, Katayama M, Takenaka N, Suemizu H, Yamada R, Nakamura Y, Ohtsu T, Takano Y, Imai K, Miyagi Y, Nakamura M.

Human Atopic Dermatitis Skin-derived T Cells can Induce a Reaction in Mouse Keratinocytes in vivo.
Scand J Immunol. 82(2):125-34.
Martel BC, Blom L, Dyring-Andersen B, Skov L, Thestrup-Pedersen K, Skov S, Skak K, Poulsen LK.

Tax peptide vaccine suppressed the leukemia in humanized mouse model of ATL.
Retrovirology, 12 (Suppl 1):O43.
Fujisawa J, Lee S, Yao J, Ren Y, Tanaka M.

Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype.
J Virol. 89(17):9080-9.
Shigemura T, Shiohara M, Kato M, Furuta S, Kaneda K, Morishita K, Hasegawa H, Fujii M, Gorlach A, Koike K, Kamata T.

Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells.
J Virol. 89(14):7016-27.
Kondo Y, Kimura O, Tanaka Y, Ninomiya M, Iwata T, Kogure T, Inoue J, Sugiyama M, Morosawa T, Fujisaka Y, Shimosegawa T.

The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice. (2015)
PloS One. 10(12):e0144775.
Yokoyama Y, Miyagi T, Hikita H, Yoshioka T, Mukai K, Nawa T, Sakamori R, Ohkawa K, Hiramatsu N, Takahashi T, Suemizu H, Ryo A, Tatsumi T, Takehara T.

Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.
PLoS One. 10(7):e0132041.
Wang C, Oshima M, Sashida G, Tomioka T, Hasegawa N, Mochizuki-Kashio M, Nakajima-Takagi Y, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, Iwama A.

Recent Advances in BLV Research. (HTLV)
Viruses. 2015 Nov 24;7(11):6080-8. doi: 10.3390/v7112929.
Barez PY, de Brogniez A, Carpentier A, Gazon H, Gillet N, Gutiérrez G, Hamaidia M, Jacques JR, Perike S,

The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice. (Hapatitis BV)
PLoS One. 2015 Dec 14;10(12):e0144775. doi: 10.1371/journal.pone.0144775. eCollection 2015.
Yokoyama Y, Miyagi T, Hikita H, Yoshioka T, Mukai K, Nawa T, Sakamori R, Ohkawa K, Hiramatsu N, Takahashi T, Suemizu H, Ryo A, Tatsumi T, Takehara T.

Characterization of in vivo tumorigenicity tests using severe immunodeficient NOD/Shi-scid IL2Rγ null mice for detection of tumorigenic cellular impurities in human cell-processed therapeutic products. (Tumorigenicity test)
Regen Ther. 2015 Feb 19;1:30-37. doi: 10.1016/j.reth.2014.12.001. eCollection 2015 Jun.
Kusakawa S, Machida K, Yasuda S, Takada N, Kuroda T, Sawada R, Okura H, Tsutsumi H, Kawamata S, Sato Y.

Visualization of the human CD4⁺ T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/γc(null) (NOG) mice by retrogenic expression of the human TCR gene. (HLA-DR4-NOG)
Biochem Biophys Res Commun. 2015 Jan 2;456(1):219-24. doi: 10.1016/j.bbrc.2014.11.062. Epub 2014 Nov 22.
Takahashi T, Katano I, Ito R, Ito M.

Human Atopic Dermatitis Skin-derived T Cells can Induce a Reaction in Mouse Keratinocytes in vivo. (Atopic dermatitis)
Scand J Immunol. 2015 Aug;82(2):125-34. doi: 10.1111/sji.12316.
Martel BC, Blom L, Dyring-Andersen B, Skov L, Thestrup-Pedersen K, Skov S, Skak K, Poulsen LK.

Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/ progenitor cells in vitro (mouse dental pulp stem cells)
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Nakatsuka R, Matsuoka Y, Uemura Y, Sumide K, Iwaki R, Takahashi M, Fujioka T, Sasaki Y, Sonoda Y.

Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells. (HBV)
J Virol. 2015 Jul;89(14):7016-27. doi: 10.1128/JVI.00716-15. Epub 2015 Apr 29.
Kondo Y, Kimura O, Tanaka Y, Ninomiya M, Iwata T, Kogure T, Inoue J, Sugiyama M, Morosawa T, Fujisaka Y, Shimosegawa T.

Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity. (Innate response to human cancer)
J Immunol. 2015 Aug 15;195(4):1883-90. doi: 10.4049/jimmunol.1402103. Epub 2015 Jul 13.
Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M.

Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro.
Cell Transplant. 2015;24(1):97-113.
Ryusuke Nakatsuka, Yoshikazu Matsuoka, Yasushi Uemura, Keisuke Sumide, Ryuji Iwaki, Masaya Takahashi, Tatsuya Fujioka, Yutaka Sasaki, Yoshiaki Sonoda