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文献集Hu-liver TK-NOGマウス

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文献集 Hu-liver TK-NOGマウス



Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.
Kamimura H, Ito S, Chijiwa H, Okuzono T, Ishiguro T, Yamamoto Y, Nishinoaki S, Ninomiya SI, Mitsui M, Kalgutkar AS, Yamazaki H, Suemizu H.
Xenobiotica. 2017 May;47(5):382-393.

Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.
Kai Y, Hikita H, Tatsumi T, Nakabori T, Saito Y, Morishita N, Tanaka S, Nawa T, Oze T, Sakamori R, Yakushijin T, Hiramatsu N, Suemizu H, Takehara T
J Gastroenterol. 2015 Jul 25

Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.
Soulard V, Bosson-Vanga H, Lorthiois A, Roucher C, Franetich JF, Zanghi G, Bordessoulles M, Tefit M, Thellier M, Morosan S, Le Naour G, Capron F, Suemizu H, Snounou G, Moreno-Sabater A, Mazier D.
Nat Commun. 2015 Jul 24

Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.
Takamori Miyaguchi, Hiroshi Suemizu, Makiko Shimizu, Satomi Shida, Sayako Nishiyama, Ryohji Takano, Norie Murayama, Hiroshi Yamazaki
Regulatory Toxicology and Pharmacology, 2015, Jun;72(1):71-6

Humanized TK-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity:a case study with furosemide.
Dan Xu, Sara A. Michie, Ming Zheng, Saori Takeda, Manhong Wu, Gary Peltz
J Pharmacol Exp Ther. 2015, May 11.

Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.
Koichiro Adachi, Hiroshi Suemizu, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki
Environmental Toxicology and Pharmacology, 2015, Mar 20;39(3):1067-1073

Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice with Humanized Livers.
Hidetaka Kamimura, Satoshi Ito, Kohei Nozawa, Shota Nakamura, Hiroyuki Chijiwa, Shin-ichiro Nagatsuka, Miyuki Kuronuma, Yasuyuki Ohnishi, Hiroshi Suemizu, and Shin-ichi Ninomiya
Drug Metab Dispos. 2015, Mar;43(3):309-16.

Generation of humanized liver mouse model by transplant of patient-derived fresh human hepatocytes.
Kim M, Choi B, Joo SY, Lee H, Lee JH, Lee KW, Lee S, Park JB, Lee SK, Kim SJ.
Transplant Proc. 2014, May;46(4):1186-90.

Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing.
Dan Xu, Toshi Nishimura, Sachiko Nishimura, Haili Zhang, Ming Zheng, Ying-Ying Guo, Marylin Masek, Sara A. Michie, Jeffrey Glenn, Gary Peltz.
2PLoS Med. 2014, Apr; 11(4): e1001628.

'Humanized' mouse detects deadly drug side effects.
Cohen J.
Science. 2014, Apr 18;344(6181):244-5.

Fialuridine Induces Acute Liver Failure in Chimeric TKNOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing.
Dan Xu, Toshihiko Nishimura, Ming Zheng, Manhong Wu, Hua Su, Noboru Sato, Gordon Lee, Sara Michie, Jeffrey Glenn, Gary Peltz
PLOS_ONE, 2014, Apr 15;11(4):e1001628

Chimeric TK-NOG Mice: A Predictive Model for Cholestatic Human Liver Toxicity.
Dan Xu, Manhong Wu, Sachiko Nishimura, Toshihiko Nishimura, Sara A. Michie, Ming Zheng, Zicheng Yang, Alexander John Yates, Jeffrey S. Day, Kathleen M. Hillgren, Saori Takedai Takeda, Yuan Guan, Yingying Guo, Gary Peltz
J Pharmacol Exp Ther. 2014, Feb;352(2):274-80.

The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.
Higuchi Y, Kawai K, Yamazaki H, Nakamura M, Bree F, Guguen-Guillouzo C, Suemizu H.
Xenobiotica. 2014, Jan;44(2):146-53.

A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections
Kosaka K, Hiraga N, Imamura M, Yoshimi S, Murakami E, Nakahara T, Honda Y, Ono A, Kawaoka T, Tsuge M, Abe H, Hayes CN, Miki D, Aikata H, Ochi H, Ishida Y, Tateno C, Yoshizato K, Sasaki T, Chayama K.
Biochem Biophys Res Commun. 2013, Nov 8;441(1):230-5

Can 'humanized' mice improve drug development in the 21st century?
Peltz G.
Trends Pharmacol Sci. 2013, May;34(5):255-60

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.
Yamazaki H, Suemizu H, Murayama N, Utoh M, Shibata N, Nakamura M, Guengerich FP.
Chem Res Toxicol. 2013, Mar 18;26(3):486-9

Human pharmacogenetic analysis in chimeric mice with ‘humanized livers’
Yajing Hu, Manhong Wu, Toshihiko Nishimura, Ming Zheng, Gary Peltz
Pharmacogenet Genomics. 2013, Feb;23(2):78-83

Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interactions.
Toshihiko Nishimura, Yajing Hu, Manhong Wu, Edward Pham, Hiroshi Suemizu, Menashe Elazar, Michael Liu, Ramazan Idilman, Cihan Yurdaydin, Peter Angus, Catherine Stedman, Brian Murphy, Jeffrey Glenn, Masato Nakamura, Tatsuji Nomura, Yuan Chen, Ming Zheng, William L. Fitch, Gary Peltz.
J Pharmacol Exp Ther. 2013, Feb ; 344(2): 388-96

Enabling Autologous Human Liver Regeneration With Differentiated Adipocyte Stem Cells
Dan Xu, Toshihiko Nishimura, Ming Zheng, Manhong Wu, Hua Su, Noboru Sato, Gordon Lee, Sara Michie, Jeffrey Glenn, Gary Peltz
Cell Transplant. 2013, 23(12):1573-84

In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.
Yamazaki H, Suemizu H, Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP.
Chem Res Toxicol. 2012, Feb 20;25(2):274-6

The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M, Suemizu H.
Biochem Biophys Res Commun. 2011, Feb 18;405(3):405-10

Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure.
Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Osaki M, Kato T, Okochi H, Ochiya T.
J Gastroenterol Hepatol. 2009, Jan;24(1):70-7