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文献集NOGマウス

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文献集 NOGマウス



免疫

Hematopoietic stem cell engraftment

NK Cell function

ANTIBODY-DEPENDENT-CELLULAR CYTOTOXICITY (ADCC)

T AND/OR B CELL FUNCTION

TRANSPLANTATION RESEARCH AND GRAFT VERSUS HOST DISEASE (GVHD)

感染症/ウィルス学

HIV

HTLV-1

EPSTEIN-BARR VIRUS

OTHER INFECTIOUS DISEASES

NOG AS SUPERIOR HOST FOR ENGRAFTMENT OF HUMAN CANCER CELL LINES

MYELOMA

MELANOMA

LYMPHOMA

PROSTATE CANCER

GASTRIC CANCER

BREAST CANCER

LEUKEMIA

PANCREATIC AND OTHER BILIARY TRACT CANCERS

HEPATOCELLULAR CARCINOMA (HCC)

COLON CANCER

LUNG CANCER

METASTASES

BENIGN TUMORS

PATIENT-DERIVED TUMORS (PDX)

CANCER IMMUNOTHERAPY

幹細胞/再生医学/組織工学

REGENERATION OF HUMAN TISSUE

DIFFERENTIATION OF HSC INTO HEPATOCYTES

iPS CELLS

その他

INFLAMMATION AND AUTOIMMUNE DISEASE

OTHER DISEASES

THERAPEUTIC EFFICACY EVALUATION

SAFETY ASSESSMENT/TOXICOLOGY

Hematopoietic stem cell engraftment


Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, Ueyama Y, Koyanagi Y, Zugamura K, Tsuji K, Heike T, Nakahata T. (2002) NOD/SCID/γ mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175-3182.

Saito Y, Kametani Y, Hozumi K, Mochida N, Ando K, Ito M, Nomura T, Tokuda Y, Mukuuchi H, Tajima T, Habu S. (2002) The in vivo development of human T cells from CD34+ cells in the murine thymic environment. Int Immunol 14(10):1113-1124.

Hiramatsu H, Nishikomoro R, Heike T, Ito M, Kobayshi K, Katamura K, Nakahata T. (2003) Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γc null mice model. Blood 102:873-880.

Yahata T, Ando K, Nakamura Y, Uevama Y, Shimamura K, Tamaoki N, Kato S, Hotta T. (2002) Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/shi-scid, IL-2 receptor gamma ?null mice. J Immunol 169:204-209.

Matsumura T, Kametani Y, Ando K, Hirano Y, Katano I, Ito R, Shiina M, Tsukamoto H, Saito Y, Tokuda Y, Kato S, Ito M, Motoyoshi K, Habu S. (2003) Functional CD5+ B cells develop predominantly in the spleen of NOD/SCID/γc null (NOG) mice transplanted either with human umbilical cord blood, bone marrow and mobilized peripheral blood CD34+ cells. Exp Hematol 31:789-797.

Yahata T, Ando K, Miyatake H, Uno T, Sato T, Ito M, Kato S, Hotta T. (2004) Competitive repopulation assay of two gene-marked cord blood units in NOD/SCID/γc null mice. Molecular Therapy 10(5):882-91.

Kambe N, Hiramatsu H, Shimonaka M, Fujino H, Nishikomori R, Heike T, Ito M, Kobayashi K, Ueyama Y, Matsuyoshi N, Miyachi Y, Nakahata T. (2004) Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body. Blood 103(3):860-867.

Nakata H, Maeda K, Miyakawa T, Shibuyama S, Matsuo M, Takaoka Y, Ito M, Koyanagi Y, Mitsuya H. (2005) Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor. J Virol 79(4):2087-2096.

Kai M, Hagiwara T, Emuta C, Chisaka Y, Tsuruhata K, Endo C, Inagaki Y, Miyazaki H, Kataoka S. (2009) In vivo efficacy of anti-MPL agonist antibody in promoting primary human hematopoietic cells. Blood 113(10):2213-6.

Kametani Y, Shiina M, Katano I, Ito R, Ando K, Toyama K, Tsukamoto H, Matsumura T, Saito Y, Ishikawa D, Taki T, Ito M, Imai K, Tokuda Y, Kato S, Tamaoki N, Habu S. (2006) Development of human-human hybridoma from anti-Her-2peptide-producing B cells in immunized NOG mouse. Exp Hematol 34:1239-1247.

Yahata T, Yumino S, Seng Y, Miyatake H, Uno T, Muguruma Y, Ito M,Miyoshi H, Kato S, Hotta T, Ando K. (2006) Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells. Blood 108:2446-2454.

Muguruma Y, Yahata T, Miyatake H, Sato T, Uno T, Itoh J, Kato S, Ito M, Hotta T, Ando K. (2006) Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. Blood 107:1878-1887.

Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y,Dewan MZ, Yu Z, Ito M, Morio T, Shimizu N, Honda M, Yamamoto N. (2007) Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood 109:212-218.

Watanabe S, Ohta S, Yajima M, Terashima K, M.Ito, H.Mugishima H, Fujiwara S, Shimizu K, Honda M, Shimizu N, Yamamoto .N (2007) Humanized NOD/SCID/IL2Rgamma(null) mice transplanted with hematopoietic stem cells under nonmyeloablative conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis. J Virol 81(23):13259-13264.

Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, Shiota M, Umeda K, Yoshimoto M, Ito M, Heike T, Nakahata T. (2007) Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gamma(c)null mice through cell fusion. FASEB J 21:3499-3510.

Nomura T, Tamaoki N, Takakura A, Suemizu H. (2008) Basic concept of development and practical application of animal models for human diseases. Curr Top Microbiol Immunol 324:1-24.

Ito M, Kobayashi K, Nakahata T. (2008) NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models. Curr Top Microbiol Immunol 324:53-76.

Ito R, Shiina M, Saito Y, Tokuda Y, Kametani Y, Habu S. (2008) Antigen-specific antibody production of human B cells in NOG mice reconstituted with the human immune system. Curr Top Microbiol Immunol 324:95-107.

Koyanagi Y, Tanaka Y, Ito M, Yamamoto N. (2008) Humanized mice for human retrovirus infection. Curr Top Microbiol Immunol 324:133-48.

Yamane A, Nakamura T, Suzuki H, Ito M, Ohnishi Y, Ikeda Y, Miyakawa Y. (2008) Interferon-alpha 2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes. Blood 112(3):542-50.

Nogami W, Yoshida H, Koizumi K, Yamada H, Abe K, Arimura A, Yamane N, Takahashi K, Yamane A, Oda A, Tanaka Y, Takemoto H, Ohnishi Y, Ikeda Y, Miyakawa Y. (2008) The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica 93(10):1495-504.

Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa K, Arai F, Takahashi T, Suda T. (2009) Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice. Biochem Biophys Res Commun 378(3):467-72.

Kawaguchi AT, Kametani Y, Kato S, Furuya H, Tamaoki K, Habu S. (2009) Effects of liposome-encapsulated hemoglobin on human immune system: evaluation in immunodeficient mice reconstituted with human cord blood stem cells. Artif Organs 33(2):169-76.

Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiya S, Sugamura K. (2009) The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). Int Immunol 21(7):843-58.

Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y. (2010) Dynamics of memory and naive CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rgammanull mice infected with CCR5-tropic HIV-1. Vaccine 28 Suppl 2:B32-37.

Zhang L, Meissner E, Chen J, Su L. (2010) Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci 53(2):195-203.

Wakui M, Suemizu H. (2010) [Development of humanized models using NOG mice]. Seikagaku 82(4):314-8. [Article in Japanese]

Hirosawa T, Torikai H, Yanagisawa M, Kamei M, Imahashi N, Demachi-Okamura A, Tanimoto M, Shiraishi K, Ito M, Miyamura K, Shibata K, Kikkawa F, Morishima Y, Takahashi T, Emi N, Kuzushima K, Akatsuka Y. (2011) Mismatched human leukocyte antigen class II-restricted CD8(+) cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation. Cancer Sci 102(7):1281-6.

Mizushima T, Machida K, Inoue R, Kusakawa S, Sawada R, Sato Y, Tsutsumi H. Analysis on xenograft susceptibility in NOG and NOG-hairless mice. Poster session presented at: 4th International Workshop on Humanized Mice, Seoul, South Korea, Sept 30-Oct 2, 2013. Click CIEA NOG mouse® poster.

Nakatsuka R, Matsuoka Y, Uemura Y, Sumide K, Iwaki R, Takahashi M, Fujioka T, Sasaki Y, Sonoda Y. (2013) Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro. Cell Transplant. Oct 29.

Ohshima S, Mori S, Shigenari A, Miyamoto A, Takasu M, Imaeda N, Nunomura S, Okayama Y, Tanaka M, Kitagawa H, Kulski JK, Inoko H, Ando A, Kametani Y. (2014) Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody. Biosci Trends. 8(6):308-15.

NK Cell function


Dewan Z, Terashima K, Taruishi M, Hasegawa H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, Kubuki Y, Okayama A, Fujii M, Yamamoto N. (2003) Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/γc null mice: suppression by an inhibitor against NF-κB. J Virol 77(9):5286-5294.

Dewan MZ, Terunuma H, Ahmed S, Ohba K, Takada M, Tanaka Y, Toi M,Yamamoto N. (2005) Natural killer cells in breast cancer cell growth and metastasis in SCID mice. Biomed Pharmacother 59 Suppl 2:S375-379.

Dewan MZ, Terunuma H, Toi M, Tanaka Y, Katano H, Deng X, Abe H, Nakasone T, Mori N, Sata T, Yamamoto N. (2006) Potential role of natural killer cells in controlling growth and infiltration of AIDS-associated primary effusion lymphoma cells. .

Terunuma H, Deng X, Dewan Z, Fujimoto S, Yamamoto N.  (2008) Potential role of NK cells in the induction of immune responses: implications for NK cell-based immunotherapy for cancers and viral infections. Int Rev Immunol  27:93-110.

Shiokawa M, Takahashi T, Murakami A, Kita S, Ito M, Sugamura K, Ishii N. (2010) in vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice. Biochem Biophys Res Commun 399:733-737.

Mori F, Ishida T, Ito A, Sato F, Masaki A, Narita T, Suzuki S, Yamada T, Takino H, Ri M, Kusumoto S, Komatsu H, Hishizawa M, Imada K, Takaori-Kondo A, Niimi A, Ueda R, Inagaki H, Iida S. (2013) Antitumor effects of bevacizumab in a microenvironment-dependent human adult T-cell leukemia/lymphoma mouse model. Eur J Haematol. Nov 5.

ANTIBODY-DEPENDENT-CELLULAR CYTOTOXICITY (ADCC)


Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model. Cancer Immunol Immunother 58(8):1195-206.

Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J Immunol 183(7):4782-91.

Shiokawa M, Takahashi T, Murakami A, Kita S, Ito M, Sugamura K, Ishii N. (2010) in vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice. Biochem Biophys Res Commun 399:733-737.

T AND/OR B CELL FUNCTION


Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiya S, Sugamura K. (2009) The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). Int Immunol 21(7):843-58.

Inoue M, Senju S, Hirata S, Irie A, Baba H, Nishimura Y. (2009) An in vivo model of priming of antigen-specific human CTL by Mo-DC in NOD/Shi-scid IL2rgamma(null) (NOG) mice. Immunol Lett 126(1-2):67-72.

Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y. (2010) Dynamics of memory and naive CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rgammanull mice infected with CCR5-tropic HIV-1. .

Katano I, Ito R, Eto T, Aiso S, Ito M. (2011) 14. Immunodeficient NOD-scid IL-2Rγ(null) mice do not display T and B cell leakiness. Exp Anim 60(2):181-6.

Søndergaard H, Kvist PH, Haase C. (2013) Human T cells depend on functional calcineurin, tumour necrosis factor-α and CD80/CD86 for expansion and activation in mice. Clin Exp Immunol. 172(2):300-10.

Cox JH, Hussell S, Søndergaard H, Roepstorff K, Bui JV, Deer JR, Zhang J, Li ZG, Lamberth K, Kvist PH, Padkjær S, Haase C, Zahn S, Odegard VH. (2013) Antibody-mediated targeting of the orai1 calcium channel inhibits T cell function. PLoS One. 8(12):e82944.

TRANSPLANTATION RESEARCH AND GRAFT VERSUS HOST DISEASE (GVHD)


Oh JY, Kim MK, Ko JH, Lee HJ, Kim Y, Park CS, Park CG, Kim SJ, Wee WR, Lee JH. (2009) Acute cell-mediated rejection in orthotopic pig-to-mouse corneal xenotransplantation. Xenotransplantation 16(2):74-82.

Ito R, Katano I, Kawai K, Hirata H, Ogura T, Kamisako T, Eto T, Ito M. (2009) Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice. Transplantation 15;87(11):1654-8.

Hirosawa T, Torikai H, Yanagisawa M, Kamei M, Imahashi N, Demachi-Okamura A, Tanimoto M, Shiraishi K, Ito M, Miyamura K, Shibata K, Kikkawa F, Morishima Y, Takahashi T, Emi N, Kuzushima K, Akatsuka Y. (2011) Mismatched human leukocyte antigen class II-restricted CD8(+) cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation. Cancer Sci 102(7):1281-6.

Søndergaard H, Kvist PH, Haase C. (2013) Human T cells depend on functional calcineurin, tumour necrosis factor-α and CD80/CD86 for expansion and activation in mice. Clin Exp Immunol. 172(2):300-10.

Cox JH, Hussell S, Søndergaard H, Roepstorff K, Bui JV, Deer JR, Zhang J, Li ZG, Lamberth K, Kvist PH, Padkjær S, Haase C, Zahn S, Odegard VH. (2013) Antibody-mediated targeting of the orai1 calcium channel inhibits T cell function. PLoS One. 8(12):e82944.

Tomita H, Fuchimoto Y, Mori T, Kato J, Uemura T, Handa M, Tazawa H, Ohdan H, Okamoto S, Kuroda T. (2013) Production of anti-ABO blood group antibodies after minor ABO-incompatible bone marrow transplantation in NOD/SCID/gamma(c)(null) mice. Clin Transplant. 27(6):E702-8.

Mizukami Y, Abe T, Shibata H, Makimura Y, Fujishiro SH, Yanase K, Hishikawa S, Kobayashi E, Hanazono Y. (2014) MHC-matched induced pluripotent stem cells can attenuate cellular and humoral immune responses but are still susceptible to innate immunity in pigs. PLoS One. 9(6):e98319.

Nakauchi Y, Yamazaki S, Napier SC, Usui J, Ota Y, Takahashi S, Watanabe N, Nakauchi H. (2015) Effective treatment against severe graft-versus-host disease with allele-specific anti-HLA monoclonal antibody in a humanized mouse model. Exp Hematol. 43(2):79-88.e1-4.

HIV


Dewan M Z, Terashima K, Ahmed S, Ohba K, Taruishi M, Yamamoto N. (2005)  Mouse serum factor(s) down-modulate the CD4 and CXCR4 molecules on human T cells conferring resistance to HIV infection in NOG mice. Med Microbiol Immunol  194:175-180.

Nakata H, Maeda K, Miyakawa T, Shibuyama S, Matsuo M, Takaoka Y, Ito M, Koyanagi Y, Mitsuya H. (2005) Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor. J Virol 79(4):2087-2096.

Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y,Dewan MZ, Yu Z, Ito M, Morio T, Shimizu N, Honda M, Yamamoto N. (2007) Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood 109:212-218.

Watanabe S, Ohta S, Yajima M, Terashima K, M.Ito, H.Mugishima H, Fujiwara S, Shimizu K, Honda M, Shimizu N, Yamamoto N. (2007) Humanized NOD/SCID/IL2Rgamma(null) mice transplanted with hematopoietic stem cells under nonmyeloablative conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis. J Virol 81(23):13259-13264.

Koyanagi Y, Tanaka Y, Ito M, Yamamoto N. (2008) Humanized mice for human retrovirus infection. Curr Top Microbiol Immunol 324:133-48.

Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y. (2010) Dynamics of memory and naive CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rgammanull mice infected with CCR5-tropic HIV-1. Vaccine 28 Suppl 2:B32-37.

Sato K, Izumi T, Misawa N, Kobayashi T, Yamashita Y, Ohmichi M, Ito M, Takaori-Kondo A, Koyanagi Y. (2010) Remarkable lethal G-to-A mutations in vif-proficient HIV-1 provirus by individual APOBEC3 proteins in humanized mice. J Virol 84:9546-9556.

Zhang L, Meissner E, Chen J, Su L. (2010) Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci 53(2):195-203.

Okuma K, Tanaka R, Ogura T, Ito M, Kumakura S, Yanaka M, Nishizawa M, Sugiura W, Yamamoto N, Tanaka Y. (2008) Interleukin-4-Transgenic hu-PBL-SCID Mice: A Model for the Screening of Antiviral Drugs and Immunotherapeutic Agents against X4 HIV-1 Viruses. J Infect Dis 197:134-141.

Amet T, Nonaka M, Dewan MZ, Saitoh Y, Qi X, Ichinose S, Yamamoto N, Yamaoka S. (2008) Statin-induced inhibition of HIV-1 release from latently infected U1 cells reveals a critical role for protein prenylation in HIV-1 replication. Microbes Infect 10:471-480.

HTLV-1


Ito M, Koyanagi Y, Terashima K, Yamamoto N, Nakahata T, Ueyama Y, Tamaoki N, Nomura T.   (2003) NOG (NOD/Shi-scid, γcnull) mouse-HIV-1 and HTLV-1 infection model using NOG mice allowing an efficient transplantation of human cells. Proc. Japanese Society of Animal Models for Human Diseases 19:23-30. (in Japanese)

Takajo I, Umeki K, Morishita K, Yamamoto I, Kubuki Y, Hatakeyama K, Kataoka H, Okayama A. (2007) Engraftment of peripheral blood mononuclear cells from human T-lymphotropic virus type 1 carriers in NOD/SCID/gammac(null) (NOG) mice. Int J Cancer 121(10):2205-11.

Yamamoto I, Takajo I, Umeki K, Morishita K, Hatakeyama K, Kataoka H, Nomura H, Okayama A. (2010) Multiple integrations of human T-lymphotropic virus type 1 proviruses in the engrafted cells from the asymptomatic carriers in NOD/SCID/gammacnull mice. Intervirology 53:229-239.

Tezuka K, Xun R, Tei M, Ueno T, Tanaka M, Takenouchi N, Fujisawa J. (2014) An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity. Blood. 123(3):346-55.

Fujisawa J, Lee S, Yao J, Ren Y, Tanaka M. (2015) Tax peptide vaccine suppressed the leukemia in humanized mouse model of ATL. Retrovirology, 12 (Suppl 1):O43.

Shigemura T, Shiohara M, Kato M, Furuta S, Kaneda K, Morishita K, Hasegawa H, Fujii M, Gorlach A, Koike K, Kamata T. (2015) Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype. J Virol. 89(17):9080-9.

EPSTEIN-BARR VIRUS


Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Honda M, Yamamoto N, Fujiwara S. (2008) A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses. J Infect Dis. 198(5):673-82.

Miyake A, Dewan MZ, Ishida T, Watanabe M, Honda M, Sata T, Yamamoto N, Umezawa K, Watanabe T, Horie R. (2008) Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-kappaB inhibitor DHMEQ. Microbes Infect 10:748-756.

Dewan MZ, Tomita M, Katano H, Yamamoto N, Ahmed S, Yamamoto M, Sata T, Mori N, Yamamoto N. (2009) An HIV protease inhibitor, ritonavir targets the nuclear factor-kappaB and inhibits the tumor growth and infiltration of EBV-positive lymphoblastoid B cells.  Int J Cancer. 2009 Feb 1;124(3):622-9.

Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Yamamoto N, Fujiwara S. (2009) T cell-mediated control of Epstein-Barr virus infection in humanized mice. J Infect Dis 200(10):1611-5.

Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, Koyanagi Y. (2011) A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice. Blood 26;117(21):5663-73.

Imadome K. (2013) A novel mouse xenotransplantation model of EBV-T/NK-LPD and the application of the mouse model. Nihon Rinsho Meneki Gakkai Kaishi. 36(6):433-41.

OTHER INFECTIOUS DISEASES


Andreassen J, Ito A, Ito M, Nakao M, Nakaya K. (2004) Hymenolepis microstoma: direct life cycle in immunodeficient mice. J Helminthol 78(1):1-5.

Yamauchi Y, Izumi Y, Asakura K, Kawai K, Wakui M, Ohmura M, Suematsu M, Nomori H. (2013) Lewis lung carcinoma progression is facilitated by TIG-3 fibroblast cells. Anticancer Res. 33(9):3791-8.

Kondo Y, Kimura O, Tanaka Y, Ninomiya M, Iwata T, Kogure T, Inoue J, Sugiyama M, Morosawa T, Fujisaka Y, Shimosegawa T. (2015) Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells. J Virol. 89(14):7016-27.
Yokoyama Y, Miyagi T, Hikita H, Yoshioka T, Mukai K, Nawa T, Sakamori R, Ohkawa K, Hiramatsu N, Takahashi T, Suemizu H, Ryo A, Tatsumi T, Takehara T. (2015) The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice. PloS One. 10(12):e0144775.

NOG AS SUPERIOR HOST FOR ENGRAFTMENT OF HUMAN CANCER CELL LINES


Machida K, Suemizu H, Kawai K, Ishikawa T, Sawada R, Ohnishi Y, Tsuchiya T. (2009) Higher susceptibility of NOG mice to xenotransplanted tumors. J Toxicol Sci 34(1):123-7.

Mizushima T, Machida K, Inoue R, Kusakawa S, Sawada R, Sato Y, Tsutsumi H. Analysis on xenograft susceptibility in NOG and NOG-hairless mice. Poster session presented at: 4th International Workshop on Humanized Mice, Seoul, South Korea, Sept 30-Oct 2, 2013. Click CIEA NOG mouse® poster.

MYELOMA


Hosen N, Matsuoka Y, Kishida S, Nakata J, Mizutani Y, Hasegawa K, Mugitani A, Ichihara H, Aoyama Y, Nishida S, Tsuboi A, Fujiki F, Tatsumi N, Nakajima H, Hino M, Kimura T, Yata K, Abe M, Oka Y, Oji Y, Kumanogoh A, Sugiyama H. (2012) CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients. Leukemia. 26(9):2135-41.  

Iriuchishima H1, Takubo K, Miyakawa Y, Nakamura-Ishizu A, Miyauchi Y, Fujita N, Miyamoto K, Miyamoto T, Ikeda E, Kizaki M, Nojima Y, Suda T. (2012) Neovascular niche for human myeloma cells in immunodeficient mouse bone. PLoS One. 7(2):e30557.

Miyakawa Y, Ohnishi Y, Tomisawa M, Monnai M, Kohmura K, Ueyama Y, Ito M, Ikeda Y, Kizaki M, Nakamura M. (2004) Establishment of a new model of human multiple myeloma using NOD/SCID/gammac(null) (NOG) mice. Biochem Biophys Res Commun. 313:258-262.

Dewan Z, Watanabe M, Terashima K, Aoki M, Sata T, Honda M, Ito M, Yamaoka S, Watanabe T, Horie R, Yamamoto N. (2004) Prompt tumor formation and maintenance of constitutive NF-κB activity of multiple myeloma cells in NOD/SCID/gammacnull mice. Cancer Sci 95(7):564-568.

MELANOMA


Einarsdottir BO, Bagge RO, Bhadury J, Jespersen H, Mattsson J, Nilsson LM, Truvé K, López MD, Naredi P, Nilsson O, Stierner U, Ny L, Nilsson JA. (2014) Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions. Oncotarget. 2014 Sep 8. [Epub ahead of print]

Chijiwa T, Abe Y, Ikoma N, Yamazaki H, Tsukamoto H, Suemizu H, Kawai K, Wakui M, Nishime C, Matsumoto H, Matsuyama M, Mukai M, Ueyama Y, Nakamura M. (2009) Thrombospondin 2 inhibits metastasis of human malignant melanoma through microenvironment-modification in NOD/SCID/gammaCnull (NOG) mice. Int J Oncol 34(1):5-13.

Ikoma N, Yamazaki H, Abe Y, Oida Y, Ohnishi Y, Suemizu H, Matsumoto H, Matsuyama T, Ohta Y, Ozawa A, Ueyama Y, Nakamura M. (2005) S100A4 expression with reduced E-cadherin expression predicts distant metastasis of human malignant melanoma cell lines in the NOD/SCID/gammaCnull (NOG) mouse model. Oncol Rep 14:633-637.

LYMPHOMA


Dewan MZ, Watanabe M, Ahmed S, Terashima K, Horiuchi S, Sata T, Honda M, Ito M, Watanabe T, Horie R, Yamamoto N. (2005) Hodgkin's lymphoma cells are efficiently engrafted and tumor marker CD30 is expressed with constitutive nuclear factor-кB activity in unconditioned NOD/SCID/gammac(null). Cancer Sci 96(8):466-473.

Dewan MZ, Terunuma H, Toi M, Tanaka Y, Katano H, Deng X, Abe H, Nakasone T, Mori N, Sata T, Yamamoto N. (2006) Potential role of natural killer cells in controlling growth and infiltration of AIDS-associated primary effusion lymphoma cells. Cancer Sci 97:1381-1387.

Watanabe M, Dewan MZ, Taira M, Shoda M, Honda M, Sata T, Higashihara M, Kadin ME, Watanabe T, Yamamoto N, Umezawa K, Horie R. (2007) IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells. Lab Invest 87:372-382.

Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J Immunol 183(7):4782-91.

Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model. Cancer Immunol Immunother 58(8):1195-206.

Kato C, Fujii E, Chen YJ, Endaya BB, Matsubara K, Suzuki M, Ohnishi Y, Tamaoki N. (2009) Spontaneous thymic lymphomas in the non-obese diabetic/Shi-scid, IL-2R gamma (null) mouse. Lab Anim 43(4):402-4.

Shiokawa M, Takahashi T, Murakami A, Kita S, Ito M, Sugamura K, Ishii N. (2010) In vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice. Biochem Biophys Res Commun 399:733-737.

Ito M, Teshima K, Ikeda S, Kitadate A, Watanabe A, Nara M, Yamashita J, Ohshima K, Sawada K, Tagawa H. (2014) MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma. Blood. 123(10):1499-511.

Kitadate A, Ikeda S, Teshima K, Ito M, Toyota I, Hasunuma N, Takahashi N, Miyagaki T, Sugaya M, Tagawa H. MicroRNA-16 mediates the regulation of a senescence-apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas. Oncogenem advance online publication, 7 Dec 2015 (doi: 10.1038/onc.2015.435).

PROSTATE CANCER


Wang ZA, Toivanen R, Bergren SK, Chambon P, Shen MM. (2014) Luminal cells are favored as the cell of origin for prostate cancer. Cell Rep. 8(5):1339-46.

GASTRIC CANCER


Nadauld LD, Garcia S, Natsoulis G, Bell JM, Miotke L, Hopmans ES, Xu H, Pai RK, Palm C, Regan JF, Chen H, Flaherty P, Ootani A, Zhang NR, Ford JM, Kuo CJ, Ji HP. (2014) Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. Genome Biol. 15(8):428.

Li X, Nadauld L, Ootani A, Corney DC, Pai RK, Gevaert O, Cantrell MA, Rack PG, Neal JT, Chan CW, Yeung T, Gong X, Yuan J, Wilhelmy J, Robine S, Attardi LD, Plevritis SK, Hung KE, Chen CZ, Ji HP, Kuo CJ. (2014) Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat Med. 20(7):769-77.

BREAST CANCER


Borriello L, Montès M, Lepelletier Y, Leforban B, Liu WQ, Demange L, Delhomme B, Pavoni S, Jarray R, Boucher JL, Dufour S, Hermine O, Garbay C, Hadj-Slimane R, Raynaud F. (2014) Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model. Cancer Lett. 349(2):120-7.

Poillet L, Pernodet N, Boyer-Guittaut M, Adami P, Borg C, Jouvenot M, Delage-Mourroux R, Despouy G. (2014) QSOX1 inhibits autophagic flux in breast cancer cells. PLoS One. 9(1):e86641.

Dewan MZ, Terunuma H, Ahmed S, Ohba K, Takada M, Tanaka Y, Toi M,Yamamoto N. (2005) Natural killer cells in breast cancer cell growth and metastasis in SCID mice. Biomed Pharmacother 59 Suppl 2:S375-379.

Dewan MZ, Terunuma H, Takada M, Tanaka Y, Abe H, Sata T, Toi M, Yamamoto N. (2006) Role of natural killer cells in hormone-independent rapid tumor formation and spontaneous metastasis of breast cancer cells in vivo. Breast Cancer Res Treat 104(3):267-75.

Dewan MZ, Ahmed S, Iwasaki Y, Ohba K, Toi M, Yamamoto N. (2006) Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer. Biomed Pharmacother 60:273-276.

McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F. (2015) Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes. PLoS One. 10(9):e0136851.

Bertelsen LB, Bohn AB, Shen YY, Falborg L, Stodkilde-Jorgensen H, Horsman MR. (2014) Treatment with a vascular disrupting agent does not increase recruitment of indium labelled human endothelial outgrowth cells in an experimental tumour model. BMC Cancer. 14:903.

Pernodet N, Hermetet F, Adami P, Vejux A, Descotes F, Borg C, Adams M, Pallandre JR, Viennet G, Esnard F, Jouvenot M, Despouy G. (2012) High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients. Breast Cancer Res. 14(5):R136.

LEUKEMIA


Dewan Z, Terashima K, Taruishi M, Hasegawa H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, Kubuki Y, Okayama A, Fujii M, Yamamoto N. (2003) Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/γc null mice: suppression by an inhibitor against NF-κB. J Virol 77(9):5286-5294.

Nakamura Y, Ito M, Yamamoto T, Yan XY, Yagasaki H, Kamachi Y, Kudo K, Kojima S. (2005) Engraftment of NOD/SCID/gammac(null) mice with multilineage neoplastic cells from patients with juvenile myelomonocytic leukaemia. Br J Haematol. 130(1):51-7.

Dewan MZ, Uchihara J, Terashima K, Honda M, Sata T, Ito M, Fujii N, Uozumi K, Tsukasaki K, Tomonaga M, Kubuki Y, Okayama A, Toi M, Mori N, Yamamoto N. (2006) Efficient intervention of growth and infiltration of primary adult T-cell leukemia cell by an HIV protease inhibitor, ritonavir. Blood 107(2):716-724.

Ninomiya M, Abe A, Yokozawa T, Ozeki K, Yamamoto K, Ito M, Ito M, Kiyoi H, Emi N, Naoe T. (2006) Establishment of a myeloid leuemia cell line, TRL-01, with MLL-ENL fusion gene. Cancer Genet Cytogenet 169:1-11.

Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M,Kiyoi H, Kinoshita T, Naoe T. (2007) Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. Leukemia 21:136-142.

Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez Bruyn VJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S. (2008) Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.  Blood 111:5118-5129.

Dewan MZ, Takamatsu N, Hidaka T, Hatakeyama K, Nakahata S, Fujisawa J, Katano H, Yamamoto N, Morishita K. (2008) Critical role for TSLC1 expression in the growth and organ infiltration of adult T-cell leukemia cells in vivo. J Virol  82:11958-11963.

Hirosawa T, Torikai H, Yanagisawa M, Kamei M, Imahashi N, Demachi-Okamura A, Tanimoto M, Shiraishi K, Ito M, Miyamura K, Shibata K, Kikkawa F, Morishima Y, Takahashi T, Emi N, Kuzushima K, Akatsuka Y. (2011) Mismatched human leukocyte antigen class II-restricted CD8(+) cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation. Cancer Sci 102(7):1281-6.

Kato I, Niwa A, Heike T, Fujino H, Saito MK, Umeda K, Hiramatsu H, Ito M, Morita M, Nishinaka Y, Adachi S, Ishikawa F, Nakahata T. (2011) Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis. PLoS One. 6(11):e27042.

Kuwatsuka Y, Minami M, Minami Y, Sugimoto K, Hayakawa F, Miyata Y, Abe A, Goff DJ, Kiyoi H, Naoe T. (2011) The mTOR inhibitor, everolimus (RAD001), overcomes resistance to imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells. Blood Cancer J. 1(5):e17.

Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K. (2011) Establishment of a xenograft model of human myelodysplastic syndromes. Haematologica 96(4):543-51.

Mori F, Ishida T, Ito A, Sato F, Masaki A, Narita T, Suzuki S, Yamada T, Takino H, Ri M, Kusumoto S, Komatsu H, Hishizawa M, Imada K, Takaori-Kondo A, Niimi A, Ueda R, Inagaki H, Iida S. (2013) Antitumor effects of bevacizumab in a microenvironment-dependent human adult T-cell leukemia/lymphoma mouse model. Eur J Haematol. Nov 5.

Hertlein E, Beckwith KA, Lozanski G, Chen TL, Towns WH, Johnson AJ, Lehman A, Ruppert AS, Bolon B, Andritsos L, Lozanski A, Rassenti L, Zhao W, Jarvinen TM, Senter L, Croce CM, Symer DE, de la Chapelle A, Heerema NA, Byrd JC. (2013) Characterization of a new chronic lymphocytic leukemia cell line for mechanistic in vitro and in vivo studies relevant to disease. PLoS One. 8(10):e76607.

Tezuka K, Xun R, Tei M, Ueno T, Tanaka M, Takenouchi N, Fujisawa J. (2014) An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity. Blood. 123(3):346-55.

Haji Y, Suzuki M, Moriya K, So T, Hozumi K, Mizuma M, Unno M, Ishii N. (2014) Activation of Notch1 promotes development of human CD8(+) single positive T cells in humanized mice. Biochem Biophys Res Commun. 447(2):346-51.

Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T. (2015) Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia. Retrovirology. 12:99.

Rudolph D, Impagnatiello MA, Blaukopf C, Sommer C, Gerlich DW, Roth M, Tontsch-Grunt U, Wernitznig A, Savarese F, Hofmann MH, Albrecht C, Geiselmann L, Reschke M, Garin-Chesa P, Zuber J, Moll J, Adolf GR, Kraut N. (2015) Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia. J Pharmacol Exp Ther. 352(3):579-89.

Veomett N, Dao T, Liu H, Xiang J, Pankov D, Dubrovsky L, Whitten JA, Park SM, Korontsvit T, Zakhaleva V, Casey E, Curcio M, Kharas MG, O'Reilly RJ, Liu C, Scheinberg DA. (2014) Therapeutic efficacy of an Fc-enhanced TCR-like antibody to the intracellular WT1 oncoprotein. Clin Cancer Res. 20(15):4036-46.

Gritsman K, Yuzugullu H, Von T, Yan H, Clayton L, Fritsch C, Maira SM, Hollingworth G, Choi C, Khandan T, Paktinat M, Okabe RO, Roberts TM, Zhao JJ. (2014) Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110a. J Clin Invest. 124(4):1794-809.

PANCREATIC AND OTHER BILIARY TRACT CANCERS


Suemizu H, Monnai M, Ohnishi Y, Ito M, Tamaoki N, Nakamura M. (2007) Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel new quantitative model of metastasis in NOD/SCID/gammacnull (NOG) mice. Int J Oncol 31(4):741-51.

Yoshimura H, Matsuda Y, Naito Z, Ishiwata T. (2013) In Vivo Bioluminescence Imaging of Pancreatic Cancer Xenografts in NOG Mice. J Carcinogene Mutagene S9.

Ito M, Teshima K, Ikeda S, Kitadate A, Watanabe A, Nara M, Yamashita J, Ohshima K, Sawada K, Tagawa H. (2014) MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma. Blood. 123(10):1499-511.

Matsuda Y, Yoshimura H, Ueda J, Naito Z, Korc M, Ishiwata T. (2014) Nestin Delineates Pancreatic Cancer Stem Cells in Metastatic Foci of NOD/Shi-scid IL2Rγ(null) (NOG) Mice. Am J Pathol. 184(3):674-85.

Tamai K, Nakamura M, Mizuma M, Mochizuki M, Yokoyama M, Endo H, Yamaguchi K, Nakagawa T, Shiina M, Unno M, Muramoto K, Sato I, Satoh K, Sugamura K, Tanaka N. (2014) Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma. Cancer Sci. 105(6):667-74.

Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M. (2015) Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity. J Immunol. 2015 Jul 13. pii: 1402103. [Epub ahead of print]

Li X, Nadauld L, Ootani A, Corney DC, Pai RK, Gevaert O, Cantrell MA, Rack PG, Neal JT, Chan CW, Yeung T, Gong X, Yuan J, Wilhelmy J, Robine S, Attardi LD, Plevritis SK, Hung KE, Chen CZ, Ji HP, Kuo CJ. (2014) Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat Med. 20(7):769-77.

HEPATOCELLULAR CARCINOMA (HCC)


Kimura O, Takahashi T, Ishii N, Inoue Y, Ueno Y, Kogure T, Fukushima K, Shiina M, Yamagiwa Y, Kondo Y, Inoue J, Kakazu E, Iwasaki T, Kawagishi N, Shimosegawa T, Sugamura K. (2010) Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines. Cancer Sci 101:2145-2155.

Kondo Y, Kimura O, Tanaka Y, Ninomiya M, Iwata T, Kogure T, Inoue J, Sugiyama M, Morosawa T, Fujisaka Y, Shimosegawa T. (2015) Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells. J Virol. 89(14):7016-27.

COLON CANCER


Handa K, Ohmura M, Nishime C, Hishiki T, Nagahata Y, Kawai K, Suemizu H, Nakamura M, Wakui M, Kitagawa Y, Suematsu M, Tsukada K. (2010) Phosphorescence-assisted microvascular O(2) measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice. Adv Exp Med Biol 662:423-9.

Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H. (2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rγnull (NOG) mice. Int J Oncol 32:153-159.

Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M. (2015) Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity. J Immunol. 2015 Jul 13. pii: 1402103. [Epub ahead of print]

Li X, Nadauld L, Ootani A, Corney DC, Pai RK, Gevaert O, Cantrell MA, Rack PG, Neal JT, Chan CW, Yeung T, Gong X, Yuan J, Wilhelmy J, Robine S, Attardi LD, Plevritis SK, Hung KE, Chen CZ, Ji HP, Kuo CJ. (2014) Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat Med. 20(7):769-77.

Bacac M, Fauti T, Sam J, Colombetti S, Weinzierl T, Ouaret D, Bodmer WF, Lehmann S, Hofer T, Hosse RJ, Moessner E, Ast O, Bruenker P, Grau-Richards S, Schaller T, Seidl A, Gerdes CA, Perro M, Nicolini V, Steinhoff N, Dudal S, Neumann S, von Hirschheydt T, Jaeger C, Saro J, Karanikas V, Klein C, Umana P. (2016) A Novel Carcinoembryonic Antigen T Cell Bispecific Antibody (CEA TCB) For The Treatment Of Solid Tumors. Clin Cancer Res. [Epub ahead of print].

LUNG CANCER


Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KS, Wallner OA, Hammarström LG, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Puigvert JC, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jensen AJ, Artursson P, Nilsson JA, Stenmark P, Scobie M, Berglund UW, Helleday T. (2014) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 508(7495):215-21.

Gomez-Casal R, Bhattacharya C, Epperly MW, Basse PH, Wang H, Wang X, Proia DA, Greenberger JS, Socinski MA, Levina V. (2015) The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells. Cancers (Basel). 7(2):876-907.

METASTASES


Suemizu H, Monnai M, Ohnishi Y, Ito M, Tamaoki N, Nakamura M. (2007) Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel new quantitative model of metastasis in NOD/SCID/gammacnull (NOG) mice. Int J Oncol 31(4):741-51.

Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H. (2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice. J Oncol 32:153-159.

Nakamura M, Suemizu H. (2008) Novel metastasis models of human cancer in NOG mice. Curr Top Microbiol Immunol 324:167-77.

Handa K, Ohmura M, Nishime C, Hishiki T, Nagahata Y, Kawai K, Suemizu H, Nakamura M, Wakui M, Kitagawa Y, Suematsu M, Tsukada K. (2010) Phosphorescence-assisted microvascular O(2) measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice. Adv Exp Med Biol 662:423-9.

Kubo A, Ohmura M, Wakui M, Harada T, Kajihara S, Ogawa K, Suemizu H, Nakamura M, Setou M, Suematsu M. (2011) Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice. Anal Bioanal Chem 400(7):1895-904.

Yoshimura H, Matsuda Y, Naito Z, Ishiwata T. (2013) In Vivo Bioluminescence Imaging of Pancreatic Cancer Xenografts in NOG Mice. J Carcinogene Mutagene S9.

Matsuda Y, Yoshimura H, Ueda J, Naito Z, Korc M, Ishiwata T. (2014) Nestin Delineates Pancreatic Cancer Stem Cells in Metastatic Foci of NOD/Shi-scid IL2Rγ(null) (NOG) Mice. Am J Pathol. 184(3):674-85.

Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M. (2015) Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity. J Immunol. 2015 Jul 13. pii: 1402103. [Epub ahead of print]

Kitadate A, Ikeda S, Teshima K, Ito M, Toyota I, Hasunuma N, Takahashi N, Miyagaki T, Sugaya M, Tagawa H. MicroRNA-16 mediates the regulation of a senescence-apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas. Oncogenem advance online publication, 7 Dec 2015 (doi: 10.1038/onc.2015.435).

BENIGN TUMORS


Tsuiji K, Takeda T, Li B, Kondo A, Ito M, Yaegashi N. (2010) Establishment of a novel xenograft model for human uterine leiomyoma in immunodeficient mice. Tohoku J Exp Med 222:55-61.

PATIENT-DERIVED TUMORS (PDX)


Einarsdottir BO, Bagge RO, Bhadury J, Jespersen H, Mattsson J, Nilsson LM, Truvé K, López MD, Naredi P, Nilsson O, Stierner U, Ny L, Nilsson JA. (2014) Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions. Oncotarget. 2014 Sep 8. [Epub ahead of print]

Fujii E, Suzuki M, Matsubara K, Watanabe M, Chen YJ, Adachi K, Ohnishi Y, Tanigawa M, Tsuchiya M, Tamaoki N. (2008) Establishment and characterization of in vivo human tumor models in the NOD/SCID/gamma(c)(null) mouse. Pathol Int 58(9):559-67.

Kobayashi S, Yamada-Okabe H, Suzuki M, Natori O, Kato A, Matsubara K, Jau Chen Y, Yamazaki M, Funahashi S, Yoshida K, Hashimoto E, Watanabe Y, Mutoh H, Ashihara M, Kato C, Watanabe T, Yoshikubo T, Tamaoki N, Ochiya T, Kuroda M, Levine AJ, Yamazaki T. (2012) LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells. 30(12):2631-44.

Mori F, Ishida T, Ito A, Sato F, Masaki A, Takino H, Ri M, Kusumoto S, Komatsu H, Ueda R, Inagaki H, Iida S. (2012) Potent antitumor effects of bevacizumab in a microenvironment-dependent human lymphoma mouse model. Blood Cancer J. 2(4):e67.

Zhang Y, Patel S, Abdelouahab H, Wittner M, Willekens C, Shen S, Betems A, Joulin V, Opolon P, Bawa O, Pasquier F, Ito M, Fujii N, Gonin P, Solary E, Vainchenker W, Coppo P, De Botton S, Louache F. (2012) CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model. Cell Death Dis. 3:e396.

Joo KM, Kim J, Jin J, Kim M, Seol HJ, Muradov J, Yang H, Choi YL, Park WY, Kong DS, Lee JI, Ko YH, Woo HG, Lee J, Kim S, Nam DH. (2013) Patient-specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ. Cell Rep. 3(1):260-73.

Masaki A, Ishida T, Suzuki S, Ito A, Mori F, Sato F, Narita T, Yamada T, Ri M, Kusumoto S, Komatsu H, Tanaka Y, Niimi A, Inagaki H, Iida S, Ueda R. (2013) Autologous Tax-specific CTL therapy in a primary adult T cell leukemia/lymphoma cell-bearing NOD/Shi-scid, IL-2Rγnull mouse model. J Immunol. 191(1):135-44.

Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KS, Wallner OA, Hammarström LG, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Puigvert JC, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jensen AJ, Artursson P, Nilsson JA, Stenmark P, Scobie M, Berglund UW, Helleday T. (2014) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 508(7495):215-21.

Chijiwa T, Kawai K, Noguchi A, Sato H, Hayashi A, Cho H, Shiozawa M, Kishida T, Morinaga S, Yokose T, Katayama M, Takenaka N, Suemizu H, Yamada R, Nakamura Y, Ohtsu T, Takano Y, Imai K, Miyagi Y, Nakamura M. (2015) Establishment of patient-derived cancer xenografts in immunodeficient NOG mice. Int J Oncol. 47(1):61-70.

CANCER IMMUNOTHERAPY


Inoue M, Senju S, Hirata S, Irie A, Baba H, Nishimura Y. (2009) An in vivo model of priming of antigen-specific human CTL by Mo-DC in NOD/Shi-scid IL2rgamma(null) (NOG) mice. Immunol Lett 126(1-2):67-72.

Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J Immunol 183(7):4782-91.

Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model. Cancer Immunol Immunother 58(8):1195-206.

Shirakura Y, Mizuno Y, Wang L, Imai N, Amaike C, Sato E, Ito M, Nukaya I, Mineno J, Takesako K, Ikeda H, Shiku H. (2012) T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/γcnull mice. Cancer Sci. 103(1):17-25.

Masaki A, Ishida T, Suzuki S, Ito A, Mori F, Sato F, Narita T, Yamada T, Ri M, Kusumoto S, Komatsu H, Tanaka Y, Niimi A, Inagaki H, Iida S, Ueda R. (2013) Autologous Tax-specific CTL therapy in a primary adult T cell leukemia/lymphoma cell-bearing NOD/Shi-scid, IL-2Rγnull mouse model. J Immunol. 191(1):135-44.

Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada K, Dorrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S. (2013) Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells. Cancer Res. 73(1):62-73.

Tamai K, Nakamura M, Mizuma M, Mochizuki M, Yokoyama M, Endo H, Yamaguchi K, Nakagawa T, Shiina M, Unno M, Muramoto K, Sato I, Satoh K, Sugamura K, Tanaka N. (2014) Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma. Cancer Sci. 105(6):667-74.

Schmittnaegel M, Levitsky V, Hoffmann E, Georges G, Mundigl O, Klein C, Knoetgen H. (2015) Committing Cytomegalovirus-Specific CD8 T Cells to Eliminate Tumor Cells by Bifunctional Major Histocompatibility Class I Antibody Fusion Molecules. Cancer Immunol Res. 3(7):764-76.

Bacac M, Fauti T, Colombetti S, Sam J, Nicolini V, Steinhoff N, Ast O, Bruenker P, Hosse R, Hofer T, Moessner E, Jaeger C, Saro J, Karanikas V, Klein C, Umana P. (2015) CEA TCB, A novel T-cell bispecific antibody with potent in vitro and in vivo antitumour activity against solid tumours. Eur J Cancer. 51(S1):S13.

Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T. (2015) Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia. Retrovirology. 2:99.

Bacac M, Fauti T, Sam J, Colombetti S, Weinzierl T, Ouaret D, Bodmer WF, Lehmann S, Hofer T, Hosse RJ, Moessner E, Ast O, Bruenker P, Grau-Richards S, Schaller T, Seidl A, Gerdes CA, Perro M, Nicolini V, Steinhoff N, Dudal S, Neumann S, von Hirschheydt T, Jaeger C, Saro J, Karanikas V, Klein C, Umana P. (2016) A Novel Carcinoembryonic Antigen T Cell Bispecific Antibody (CEA TCB) For The Treatment Of Solid Tumors. Clin Cancer Res. [Epub ahead of print].

Veomett N, Dao T, Liu H, Xiang J, Pankov D, Dubrovsky L, Whitten JA, Park SM, Korontsvit T, Zakhaleva V, Casey E, Curcio M, Kharas MG, O'Reilly RJ, Liu C, Scheinberg DA. (2014) Therapeutic efficacy of an Fc-enhanced TCR-like antibody to the intracellular WT1 oncoprotein. Clin Cancer Res. 20(15):4036-46.

REGENERATION OF HUMAN TISSUE


Matsuura-Sawada R, Murakami T, Ozawa Y, Nabeshima H, Akahira J, SatoY, Koyanagi Y, Ito M, Terada Y, Okamura K. (2005) Reproduction of menstrual changes in transplanted human endometrial tissue in immunodeficient mice. Hum Reprod 20:1477-1484.

Masuda H, Maruyama T, Hiratsu E, Yamane J, Iwanami A, Nagashima T, Ono M, Miyoshi H, Okano HJ, Ito M, Tamaoki N, Nomura T, Okano H, MatsuzakiY, Yoshimura Y. (2007) Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/gamma c(null) immunodeficient mice. Proc Natl Acad Sci U S A 104:1925-1930.

Ono, M, Maruyama T, Masuda H, Kajitani T, Nagashima T, Arase T, Ito M, Ohta K, Uchida H, Asada H, Yoshimura Y, Okano H, Matsuzaki Y. (2007) Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells. Proc Natl Acad Sci U S A 104(47):18700-5.

Terada Y, Terunuma-Sato Y, Kakoi-Yoshimoto T, Hasegawa H, Ugajin T, Koyanagi Y, Ito M, Murakami T, Sasano H, Yaegashi N, Okamura K. (2008) Development of human Graafian follicles following transplantation of human ovarian tissue into NOD/SCID/gammac null mice. Am J Reprod Immunol 60(6):534-40.

Suemizu H, Hasegawa M, Kawai K, Taniguchi K, Monnai M, Wakui M, Suematsu M, Ito M, Peltz G, Nakamura M. (2008) Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice. Biochem Biophys Res Commun 377(1):248-52.

Oh JY, Kim MK, Ko JH, Lee HJ, Kim Y, Park CS, Park CG, Kim SJ, Wee WR, Lee JH. (200 Acute cell-mediated rejection in orthotopic pig-to-mouse corneal xenotransplantation. Xenotransplantation 16(2):74-82.

Watanabe T, Hayashi H, Kita K, Kubota Y, Ogawa T. (2009) Ectopic porcine spermatogenesis in murine subcutis: tissue grafting versus cell-injection methods. Asian J Androl 11(3):317-23.

Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H. (2010) Stem cell-like properties of the endometrial side population: implication in endometrial regeneration. PLoS One 5:e10387.

Kikuchi-Arai M, Murakami T, Utsunomiya H, Akahira J, Suzuki-Kakisaka H, Terada Y, Tachibana M, Hayasaka S, Ugajin T, Yaegashi N. (2010) Establishment of long-term model throughout regular menstrual cycles in immunodeficient mice. Am J Reprod Immunol 64:324-332.

Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M (2011) The reconstituted 'humanized liver' in TK-NOG mice is mature and functional. Biochem Biophysical Res Communications 405:405-410.

Yamazaki H, Suemizu H, Igaya S, Shimizu M, Shibata N, Nakamura M. (2011) in vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice. Chem Res Toxicol 24(3):287-9.

Yahata T, Muguruma Y, Yumino S, Sheng Y, Uno T, Matsuzawa H, Ito M, Kato S, Hotta T, Ando K. (2008) Quiescent Human Hematopoietic Stem Cells in the Bone Marrow Niches Organize the Hierarchical Structure of Hematopoiesis. Stem Cells 26:3228-3236.

Kishi Y, Tanaka Y, Shibata H, Nakamura S, Takeuchi K, Masuda S, Ikeda T, Muramatsu S, Hanazono Y. (2008) Variation in the incidence of teratomas after the transplantation of nonhuman primate ES cells into immunodeficient mice. Cell Transplant 17:1095-1102.

Ogawa D, Okada Y, Nakamura M, Kanemura Y, Okano HJ, Matsuzaki Y, Shimazaki T, Ito M, Ikeda E, Tamiya T, Nagao S, Okano H. (2009) Evaluation of Human Fetal Neural Stem/Progenitor Cells as a Source for Cell Replacement Therapy for Neurological Disorders: Properties and Tumorigenicity After Long-Term In Vitro Maintenance. J Neuro Res 87:307-317.

Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K. (2011) Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells. Blood 118(11):2941-50.

Kato T, Hisasue M, Segawa K, Fujimoto A, Makiishi E, Neo S, Yasuno K, Kobayashi R, Tsuchiya R. (2013) Accumulation of Xenotransplanted Canine Bone Marrow Cells in NOD/SCID/γc(null) Mice with Acute Hepatitis Induced by CCl4. J Vet Med Sci. 75(7):847-55.

Wang C, Oshima M, Sashida G, Tomioka T, Hasegawa N, Mochizuki-Kashio M, Nakajima-Takagi Y, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, Iwama A. (2015) Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice. PLoS One. 10(7):e0132041.

Marg A, Escobar H, Gloy S, Kufeld M, Zacher J, Spuler A, Birchmeier C, Izsvak Z, Spuler S. (2014) Human satellite cells have regenerative capacity and are genetically manipulable. J Clin Invest. 124(10):4257-65.

DIFFERENTIATION OF HSC INTO HEPATOCYTES


Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, Shiota M, Umeda K, Yoshimoto M, Ito M, Heike T, Nakahata T. (2007) Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gamma(c)null mice through cell fusion. FASEB J 21:3499-3510.

Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H. (2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice. Int J Oncol  32:153-159

iPS CELLS


Mizukami Y, Abe T, Shibata H, Makimura Y, Fujishiro SH, Yanase K, Hishikawa S, Kobayashi E, Hanazono Y. (2014) MHC-matched induced pluripotent stem cells can attenuate cellular and humoral immune responses but are still susceptible to innate immunity in pigs. PLoS One. 9(6):e98319.

REGENERATION OF HUMAN TISSUE


Doshi M, Koyanagi M, Nakahara M, Saeki K, Saeki K, Yuo A. (2006) Identification of human neutrophils during experimentally induced inflammation in mice with transplanted CD34+ cells from human umbilical cord blood. Int J Hematol 84:231-237.

Saito N, Yoshioka N, Abe R, Qiao H, Fujita Y, Hoshina D, Suto A, Kase S, Kitaichi N, Ozaki M, Shimizu H. (2012) Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients. J Allergy Clin Immunol. 131(2):434-41.e1-9.

Martel BC, Blom L, Dyring-Andersen B, Skov L, Thestrup-Pedersen K, Skov S, Skak K, Poulsen LK. (2015) Human Atopic Dermatitis Skin-derived T Cells can Induce a Reaction in Mouse Keratinocytes in vivo. Scand J Immunol. 82(2):125-34.

OTHER DISEASES


Fujii E, Kato A, Chen YJ, Matsubara K, Ohnishi Y, Suzuki M. (2014) Histopathological characteristics of human non-tumor thyroid tissues in a long-term model of adenomatous goiter xenografts in the NOD/Shi-scid, IL-2Rγ(null) mouse. Exp Toxicol Pathol. 66(4):203-9.

Ninomiya M, Kiyoi H, Ito M, Hirose Y, Naoe T. (2004) Retinoic acid syndrome in NOD/SCID mice induced by injecting an acute promyelocytic leukemia cell line. Leukemia 18:442-448.

THERAPEUTIC EFFICACY EVALUATION


Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KS, Wallner OA, Hammarström LG, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Puigvert JC, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jensen AJ, Artursson P, Nilsson JA, Stenmark P, Scobie M, Berglund UW, Helleday T. (2014) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 508(7495):215-21.

Iriuchishima H1, Takubo K, Miyakawa Y, Nakamura-Ishizu A, Miyauchi Y, Fujita N, Miyamoto K, Miyamoto T, Ikeda E, Kizaki M, Nojima Y, Suda T. (2012) Neovascular niche for human myeloma cells in immunodeficient mouse bone. PLoS One. 7(2):e30557.   

Dewan Z, Terashima K, Taruishi M, Hasegawa H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, Kubuki Y, Okayama A, Fujii M, Yamamoto N. (2003) Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/γ mice: suppression by an inhibitor against NF-κB. J Virol 77(9):5286-5294.

Nakamura T, Miyakawa Y, Miyamura A, Yamane A, Suzuki H, Ito M, Ohnishi Y, Ishiwata N, Ikeda Y, Tsuruzoe N. (2006) A novel nonpeptidyl human c-Mpl activator stimulates megakaryopoiesis and thrombopoiesis. Blood 107(11):4300-4307.

Dewan MZ, Uchihara J, Terashima K, Honda M, Sata T, Ito M, Fujii N, Uozumi K, Tsukasaki K, Tomonaga M, Kubuki Y, Okayama A, Toi M, Mori N, Yamamoto N. (2006) Efficient intervention of growth and infiltration of primary adult T-cell leukemia cell by an HIV protease inhibitor, ritonavir. Blood 107(2):716-724.

Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H. (2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice. Int J Oncol  32:153-159

Machida K, Suemizu H, Kawai K, Ishikawa T, Sawada R, Ohnishi Y, Tsuchiya T. (2009) Higher susceptibility of NOG mice to xenotransplanted tumors. J Toxicol Sci 34(1):123-7.

Kawaguchi AT, Kametani Y, Kato S, Furuya H, Tamaoki K, Habu S. (2009) Effects of liposome-encapsulated hemoglobin on human immune system: evaluation in immunodeficient mice reconstituted with human cord blood stem cells. Artif Organs 33(2):169-76.

Kai M, Hagiwara T, Emuta C, Chisaka Y, Tsuruhata K, Endo C, Inagaki Y, Miyazaki H, Kataoka S. (2009) in vivo efficacy of anti-MPL agonist antibody in promoting primary human hematopoietic cells. Blood 113(10):2213-6.

Inoue M, Senju S, Hirata S, Irie A, Baba H, Nishimura Y. (2009) An in vivo model of priming of antigen-specific human CTL by Mo-DC in NOD/Shi-scid IL2rgamma(null) (NOG) mice. Immunol Lett 126(1-2):67-72.

Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagak i H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model. Cancer Immunol Immunother 58(8):1195-206.

Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J Immunol 183(7):4782-91.

Okuma K, Tanaka R, Ogura T, Ito M, Kumakura S, Yanaka M, Nishizawa M, Sugiura W, Yamamoto N, Tanaka Y. (2008) Interleukin-4-Transgenic hu-PBL-SCID Mice: A Model for the Screening of Antiviral Drugs and Immunotherapeutic Agents against X4 HIV-1 Viruses. J Infect Dis 197:134-141.

Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H. (2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rγnull (NOG) mice. Int J Oncol  32:153-159.

Fujisawa J, Lee S, Yao J, Ren Y, Tanaka M. (2015) Tax peptide vaccine suppressed the leukemia in humanized mouse model of ATL. Retrovirology, 12 (Suppl 1):O43.

SAFETY ASSESSMENT/TOXICOLOGY


Machida K, Suemizu H, Kawai K, Ishikawa T, Sawada R, Ohnishi Y, Tsuchiya T. (2009) Higher susceptibility of NOG mice to xenotransplanted tumors. J Toxicol Sci 34(1):123-7.

Takahashi M, Tsujimura N, Yoshino T, Hosokawa M, Otsuka K, Matsunaga T, Nakasono S. (2012) Assessment of benzene-induced hematotoxicity using a human-like hematopoietic lineage in NOD/Shi-scid/IL-2Rγnull mice. PLoS One. 7(12):e50448.

Kanemura H, Go MJ, Nishishita N, Sakai N, Kamao H, Sato Y, Takahashi M, Kawamata S. (2013) Pigment Epithelium-Derived Factor Secreted from Retinal Pigment Epithelium Facilitates Apoptotic Cell Death of iPSC. Sci Rep. 3:2334.

Soleimani R, Heytens E, Darzynkiewicz Z, Oktay K. (2011) Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise. Aging (Albany NY). 3(8):782-93.