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TK-NOG mouse

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TK-NOG  mouse

In-Vivo Science Inc. started to distribute TK-NOG mouse as well as humanized liver TK-NOG mouse


The mouse on (top) left: Jaundice (ears and tail) by treatment of Gancyclovir.

(Formal name) NOD.Cg-Prkdcscid Il2rgtm1SugTg(Alb-UL23)7-2/ShiJic
(Abbreviated name) NOG-Tg(Alb-UL23)7-2/ShiJic

TK-NOG mouse is designed to be induced liver specific injury when it’s treated with the gancyclovir (GCV). In order to cause this injury, highly immunodeficient NOG mouse, TK-NOG mouse, is made to express a Herpes Simplex Virus-1 Thymidine Kinase (HSVtk) transgene driven by the mouse albumin enhancer/promoter in its liver. The human normal liver cells can rescue the liver injury by injecting the human liver cells, and these human cells form a chimeric yet a fully functional liver in the mouse. It was confirmed that the humanized liver TK-NOG mouse expresses the human albumin, complement C3 protein, transferrin as well as the ceruloplasmin. The microarray experiments showed that the global gene expression profile in the reconstituted chimeric liver of the TK-NOG mice and the donor human liver cells are highly comparable. The expression levels and patterns of the drug metabolism-related mRNAs were also evaluated. All of the mRNAs that are expressed in the donor liver cells are reproducibly expressed at the comparable or the higher levels in the livers obtained from four humanized TK-NOG mice.

Experimental models using TK-NOG

1)pharmacokinetics and pharmacodynamics
2)infection disease models, HBV and HCV