It shows severe immunodeficiency and has excellent engraftment of human cells. It is widely used in drug discovery research, including cancer research, and basic medical research.

We supply next-generation NOG mice that have been improved through genetical modifications, with the aim of improving the differentiation, engraftment, and function of human cells, or establishing human disease models.

Engraftment of human hematopoietic stem cells or peripheral blood mononuclear cells (PBMCs) into NOG/next-generation NOG mouse reconstitute the human immune system. By having a human immune system, it is possible to be useful pathological models in fields such as cancer, infectious diseases, and allergies.