Strain Name | NOG-hIL-15 Tg (NOG-IL15) |
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A vector containing the human IL-5 gene downstream of the CMV promoter was microinjected into (NOD♀ x NOG♂) F1 pronuclear stage embryos, and crossed with NOG mouse to establish them.
Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse. (Original, NOG-IL15, NK cell, ADCC, CTL)
Sci Rep. 2017 Dec 8;7(1):17230. doi: 10.1038/s41598-017-17442-7.
Katano I, Nishime C, Ito R, Kamisako T, Mizusawa T, Ka Y, Ogura T, Suemizu H, Kawakami Y, Ito M, Takahashi T.Development of Humanized Mouse Models for Studying Human NK Cells in Health and Disease.(humanized mice, NOG-IL15, NK cells)
Methods Mol Biol. 2022;2463:53-66. doi: 10.1007/978-1-0716-2160-8_5.
Shan L, Flavell RA, Herndler-Brandstetter D.Ruxolitinib, a JAK1/JAK2 selective inhibitor, ameliorates acute and chronic steroid-refractory GvHD mouse models. (humanized mice, NOG-IL15, NK cell, GVHD)
Immunotherapy. 2021 Aug;13(12):977-987. doi: 10.2217/imt-2021-0013. Epub 2021 Jun 29.
Huarte E, Peel M, Juvekar A, Dubé P, Sarah S, Stephens L, Stewart B, Long B, Czerniak P, Oliver J, Smith P.Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse. (NOG-IL15,NK cell mediated ADCC)
Front Immunol. 2020 Oct 7;11:532684. doi: 10.3389/fimmu.2020.532684. eCollection 2020.
Katano I, Ito R, Kawai K, Takahashi T.